IP Library › Granted Patent US 9,481,717
Granted Patent B2
US 9,481,717 · App. 14/505,169 · Granted Nov 1, 2016

Lectins and uses thereof

Inventors: David Markovitz (Ann Arbor, MI); Michael Swanson (Ann Arbor, MI); Irwin Goldstein (East Ann Arbor, MI); Harry Winter (Ann Arbor, MI)
Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
C07K14/42A61K38/00
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Quick Facts
Patent No.
US 9,481,717
App. No.
14/505,169
Granted
Nov 1, 2016
Kind
B2
Abstract

The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides antiviral and antimicrobial lectin compounds and methods of their use.

Claims (3)

1. A method of treating infection by a virus in a subject, comprising administering a composition comprising a variant BanLec polypeptide comprising a H84T mutation, wherein said variant BanLec polypeptide exhibits antiviral activity, and wherein said BanLec polypeptide exhibits reduced mitogenic activity relative to a wild type BanLec polypeptide to a subject diagnosed with a viral infection, wherein said infection is by a virus presenting surface mannose.

2. The method of claim 1 , wherein said virus is a Corona virus.

3. The method of claim 1 , wherein said variant BanLec polypeptide is encoded by a nucleic acid selected from the group consisting of SEQ ID NOs:4-6.

Assignments (3)
CONFIRMATORY LICENSE Recorded Dec 30, 2014
From: UNIVERSITY OF MICHIGAN
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 034714/0782 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT APPL. NO. 13/347,459 PREVIOUSLY RECORDED AT REEL: 033924 FRAME: 0793. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Oct 13, 2014
From: MARKOVITZ, DAVID; SWANSON, MICHAEL; GOLDSTEIN, IRWIN; WINTER, HARRY
To: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Reel/Frame 034094/0820 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 9, 2014
From: MARKOVITZ, DAVID; SWANSON, MICHAEL; GOLDSTEIN, IRWIN; WINTER, HARRY
To: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Reel/Frame 033924/0793 →
Continuity (3)
Continuation 13640498
Provisional Application 61324107 · Apr 14, 2010
Related Publication 20150080293A1 · Mar 19, 2015