Granted Patent B2

US 9,657,106 · App. 14/507,783 · Granted May 23, 2017

Inventors: Gregory Lazar (Indianapolis, IN); Wei Dang (Pasadena, CA); John Desjarlais (Pasadena, CA); Sher Karki (Santa Monica, CA); Omid Vafa (Monrovia, CA); Robert Hayes (Radnor, PA); Jost Vielmetter (Altadena, CA)

Assignee: Xencor, Inc.

C07K16/2893C07K16/00C07K16/18C07K16/2863C07K16/2887C07K16/2896C07K16/30C07K16/32A61K2039/505C07K2316/52C07K2317/24C07K2317/31C07K2317/34C07K2317/40C07K2317/41C07K2317/52C07K2317/56C07K2317/64C07K2317/71C07K2317/72C07K2317/732C07K2317/734C07K2317/77C07K2317/92C07K2317/94

Abstract

Claims (16)

1. A protein comprising an Fc variant of a parent human IgG Fc polypeptide, said Fc variant comprising an amino acid substitution S267E in the Fc region, wherein said Fc variant exhibits increased binding to FcγRIIb as compared to the parent Fc polypeptide and wherein numbering is according to the EU index.

2. The protein according to claim 1 , where said protein is an antibody or immunoadhesion.

3. The protein according to claim 2 , where said protein is an antibody.

4. The protein according to claim 2 , wherein said protein is an antibody and wherein said antibody is selected from the group consisting of a humanized antibody and a monoclonal antibody.

5. The protein according to claim 4 , wherein said antibody is a monoclonal antibody.

6. The protein according to claim 4 , wherein said antibody is a humanized antibody.

7. The protein according to claim 1 , wherein said parent Fc polypeptide is a human IgG1.

8. The protein according to claim 2 , wherein said protein is an immunoadhesin.

9. A protein comprising an Fc variant of a parent human IgG Fc polypeptide, said Fc variant comprising an amino acid substitution S267D in the Fc region, wherein said Fc variant exhibits increased binding to FcγRIIb as compared to the parent Fc polypeptide and wherein numbering is according to the EU index.

10. The protein according to claim 9 , wherein said protein is an antibody or immunoadhesion.

11. The protein according to claim 10 where said protein is an antibody.

12. The protein according to claim 11 , wherein said protein is an antibody, and wherein said antibody is selected from the group consisting of a humanized antibody and a monoclonal antibody.

13. The protein according to claim 12 , wherein said antibody is a monoclonal antibody.

14. The protein according to claim 13 , wherein said antibody is a humanized antibody.

15. The protein according to claim 9 wherein said parent Fc polypeptide is a human IgG1.

16. The protein according to claim 10 , wherein said protein is an immunoadhesin.

Assignments (2)

Continuity (12)