Methods for treating intrapulmonary infections
View Patent ↗This disclosure relates to the treatment of intrapulmonary bacterial infections, including treatment of nosocomial pneumonia lung infections with pharmaceutical compositions containing the cephalosporin ceftolozane.
1. A method of treating an infection selected from the group consisting of: nosocomial pneumonia, ventilator acquired pneumonia and hospital acquired pneumonia, the method comprising repeatedly intravenously administering 2.0 g of ceftolozane and 1.0 g of tazobactam to a subject in need thereof about once every 8 hours.
2. The method of claim 1 , wherein the method comprises administering the ceftolozane as a 60-minute infusion.
3. The method of claim 1 , wherein the ceftolozane is a hydrogen sulfate salt.
4. The method of claim 1 , wherein the ceftolozane and tazobactam are administered as a single pharmaceutical composition.
5. The method of claim 4 , wherein the method comprises administering the pharmaceutical composition as a 60-minute infusion.
6. The method of claim 1 , wherein the pneumonia is nosocomial pneumonia.
7. The method of claim 1 , wherein the pneumonia is ventilator acquired pneumonia.
8. The method of claim 1 , wherein the pneumonia is hospital acquired pneumonia.
9. The method of claim 1 , wherein the ceftolozane is administered in its free base form.
10. The method of claim 1 , wherein the ceftolozane is administered in its salt form.
11. The method of claim 6 , wherein the ceftolozane is administered in its free base form.
12. The method of claim 6 , wherein the ceftolozane is administered in its salt form.
13. The method of claim 1 , wherein the infection comprises one or more pathogens selected from the group consisting of: Pseudomonas aeruginosa, E. coli and K. pneumoniae.