Compositions for treating biofilms and methods for using same
Compositions containing a surface active agent and a sub-lethal amount of an antimicrobial agent and methods for using such compositions are provided herein.
1. A method for treating a wound comprising contacting the wound with a composition containing about 30 w/w % to about 80 w/w % of a surface active agent selected from the group consisting of poloxamer 127, poloxamer 188, poloxamer 237, poloxamer 335, poloxamer 407, and combinations thereof and about 1% or less by weight of the composition of an antimicrobial agent.
2. The method of claim 1 , wherein the antimicrobial agent is selected from the group consisting of antibacterial agents, antifungal agents, antiviral agents, and combinations thereof.
3. The method of claim 1 , wherein the antimicrobial agent is selected from the group consisting of furaltadone, furazolium chloride, nifuradene, nifuratel, nifurfoline, nifurpirinol, nifurprazine, nifurtoinol, nitrofurantoin, furazolidone, 2-(methoxymethyl)-5-nitrofuran, nidroxyzone, nifuroxime, nifurazide, nitrofurazone, nystatin, polymyxin, silver sulfadiazine, nanocrystalline silver, ionic silver, honey, iodine, benzalkonium chloride, alcohol, hydrogen peroxide, chlorhexidine, and combinations thereof.
4. The method of claim 1 , wherein the surface active agent is poloxamer 188.
5. The method of claim 1 , wherein contacting comprises administering the composition topically.
6. The method of claim 5 , wherein administering the composition topically is selected from the group consisting of administering by hand, administering by an extruder, spray delivery, applying a dressing including the composition, and combinations thereof.
7. The method of claim 1 , wherein contacting comprises applying the composition to a dressing and applying the dressing to the wound.
8. The method of claim 1 , wherein the wound is selected from the group consisting of burns, abrasions, cuts, scrapes, denuding tissue injuries, and combinations thereof.
9. The method of claim 1 , wherein the wound is a chronic wound.
10. The method of claim 9 , wherein chronic wound is selected from the group consisting of venous ulcers, diabetic ulcers, arterial ulcers, pressure ulcers, radiation ulcers, traumatic wounds, non-healing wounds, and combinations thereof.
11. A method for treating a diabetic ulcer comprising contacting the diabetic ulcer with a composition containing about 30 w/w % to about 80 w/w % of a surface active agent selected from the group consisting of poloxamer 127, poloxamer 188, poloxamer 237, poloxamer 335, poloxamer 407, and combinations thereof and less than 1% by weight of the composition of an antimicrobial agent.
12. The method of claim 11 , wherein the antimicrobial agent is selected from the group consisting of antibacterial agents, antifungal agents, antiviral agents, and combinations thereof.
13. The method of claim 11 , wherein the antimicrobial agent is selected from the group consisting of furaltadone, furazolium chloride, nifuradene, nifuratel, nifurfoline, nifurpirinol, nifurprazine, nifurtoinol, nitrofurantoin, furazolidone, 2-(methoxymethyl)-5-nitrofuran, nidroxyzone, nifuroxime, nifurazide, nitrofurazone, nystatin, polymyxin, silver sulfadiazine, nanocrystalline silver, ionic silver, honey, iodine, benzalkonium chloride, alcohol, hydrogen peroxide, chlorhexidine, and combinations thereof.
14. The method of claim 11 , wherein the surface active agent is poloxamer 188.
15. The method of claim 11 , wherein contacting comprises administering the composition topically.
16. The method of claim 15 , wherein administering the composition topically is selected from the group consisting of administering by hand, administering by an extruder, spray delivery, applying a dressing including the composition, and combinations thereof.
17. The method of claim 15 , wherein contacting comprises applying the composition to a dressing and applying the dressing to the wound.
18. A composition comprising:
about 30 w/w % to about 80 w/w % of a surface active agent selected from the group consisting of poloxamer 127, poloxamer 188, poloxamer 237, poloxamer 335, poloxamer 407, and combinations thereof; and
less than about 1% by weight of the composition of an antimicrobial agent.
19. The method of claim 18 , wherein the antimicrobial agent is selected from the group consisting of antibacterial agents, antifungal agents, antiviral agents, and combinations thereof.
20. The method of claim 18 , wherein the antimicrobial agent is selected from the group consisting of furaltadone, furazolium chloride, nifuradene, nifuratel, nifurfoline, nifurpirinol, nifurprazine, nifurtoinol, nitrofurantoin, furazolidone, 2-(methoxymethyl)-5-nitrofuran, nidroxyzone, nifuroxime, nifurazide, nitrofurazone, nystatin, polymyxin, silver sulfadiazine, nanocrystalline silver, ionic silver, honey, iodine, benzalkonium chloride, alcohol, hydrogen peroxide, chlorhexidine, and combinations thereof.
21. The method of claim 18 , wherein the surface active agent is poloxamer 188.
22. A composition comprising:
about 30 w/w % to about 80 w/w % poloxamer; and
less than about 1% by weight of the composition nitrofurantoin.
23. A composition comprising:
about 30 w/w % to about 80 w/w % poloxamer; and
less than about 1% by weight of the composition silver sulfadiazine.
24. A composition comprising:
about 30 w/w % to about 80 w/w % poloxamer;
less than about 1% by weight of the composition polymixin; and
less than about 1% by weight of the composition nitrofurantoin.
25. A composition comprising:
about 30 w/w % to about 80 w/w % poloxamer;
less than about 1% by weight of the composition nanocrystalline silver.
26. A composition comprising:
about 30 w/w % to about 80 w/w % poloxamer;
less than about 1% by weight of the composition ionic silver.