Methods for diagnosing and treating neuroendocrine cancer
The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods for preventing and treating neuroendocrine cancers are also disclosed.
1. A method for decreasing proliferation of a neuroendocrine tumor cell comprising contacting a neuroendocrine tumor cell with an effective amount of an antibody or an antibody fragment that specifically binds an antigenic fragment consisting of SEQ ID NO:5 of an NMDA glutamate receptor and inhibits or decreases NMDA glutamate receptor activity, thereby decreasing proliferation of the neuroendocrine tumor cell.
2. The method of claim 1 , wherein the neuroendocrine tumor cell comprises a breast, small cell lung, ovarian, prostate or pancreatic tumor cell.
3. A method for treating a neuroendocrine cancer in a subject comprising administering to a subject having a neuroendocrine cancer an effective amount of an antibody or an antibody fragment that specifically binds an antigenic fragment consisting of SEQ ID NO:5 of an NMDA glutamate receptor and inhibits or decreases NMDA glutamate receptor activity, thereby preventing or treating a neuroendocrine cancer in the subject.
4. The method of claim 3 , wherein the neuroendocrine cancer comprises breast cancer, small cell lung cancer, ovarian cancer, prostate cancer or pancreatic cancer.
5. The method of claim 3 , further comprising administering a chemotherapy or therapeutic anticancer agent.