Granted Patent
B2
US 9,279,132 · App. 14/531,200 · Granted Mar 8, 2016
Vectors and sequences for the treatment of diseases
Inventors:
Fátima Bosch Tubert (Cerdanyola del Valles, ES); Éduard Ayuso López (Olesa de Montserrat, ES); Albert Ruzo Matías (Barcelona, ES)
C12N15/86A61K48/0066C12N9/14C12N15/52C12N15/8645A61K48/00C12N2750/14143C12N2830/008C12N2830/48C12N2840/105
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Abstract
The present invention provides new sequences, gene constructions, vectors and pharmaceutical compositions for the treatment of diseases and specially, for the treatment of mucopolysaccharidoses.
Claims (4)
1. An expression vector which is an adeno-associated vector, comprising a cytomegalovirus early enhancer element and chicken β-actin promoter (CAG promoter) operably linked to the nucleotide sequence having at least 85% sequence identity with SEQ ID NO: 1.
2. The expression vector according to claim 1 , wherein the serotype of the adeno-associated vector is 1, 2, 5, 7, 8, or 9.
3. The expression vector according to claim 2 , wherein the serotype is 9.
4. A pharmaceutical composition comprising the expression vector according to claim 1 .
Assignments (3)
CHANGE OF NAME
Recorded Apr 12, 2019
From: LABORATORIOS DEL DR. ESTEVE, S.A.
To: ESTEVE PHARMACEUTICALS, S.A
Reel/Frame 048866/0889 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 3, 2014
From: BOSCH TUBERT, FATIMA; AYUSO LOPEZ, EDUARD; RUZO MATIAS, ALBERT
To: LABORATORIOS DEL DR. ESTEVE, S.A.
Reel/Frame 034090/0597 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 3, 2014
From: BOSCH TUBERT, FATIMA; AYUSO LOPEZ, EDUARD; RUZO MATIAS, ALBERT
To: UNIVERSIDAD AUTONOMA DE BARCELONA
Reel/Frame 034090/0810 →
Priority Claims (1)
EP 10382169
· Jun 10, 2010
· regional
Continuity (2)
Continuation
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