Wearable ultrasonic device for circulating tumor cell detection
An apparatus for detecting circulating tumor cells is provided. A support system for mounting on a patient is provided. An imaging system is attached to the support system. The imaging system comprises a transmitter and receiver system for generating and transmitting signals into the patient and receiving signals from the patient and a controller. The controller comprises a processor and computer readable media. The computer readable media comprises computer readable code for transmitting signals into the patient, computer readable code for receiving signals from the patent, and computer readable code for providing in vivo circulating tumor cell imaging agent data from the received signals from the patient.
1. A system for detecting circulating tumor cells in a patient, comprising:
microbubbles with an outer coating of antibodies, which attach to circulating tumor cells;
an imaging agent injector for injecting the microbubbles into the patient, wherein circulating tumor cells are attached to the microbubbles;
a support system for mounting on the patient;
an ultrasonic imaging system attached to the support system, comprising;
an ultrasonic transmitter and receiver system for generating and transmitting ultrasonic signals into the patient and receiving ultrasonic signals from the patient; and
a controller, comprising:
a processor; and
non-transient computer readable media, comprising:
computer readable code for transmitting ultrasonic signals into the patient;
computer readable code for receiving ultrasonic signals from the patent;
computer readable code for determining the presence of in vivo circulating tumor cells from the received ultrasonic signals from the patient; and
computer readable code for determining the number of circulating tumor cells in a location of detection of the patient.
2. The system, as recited in claim 1 , wherein the ultrasonic transmitter and receiver system comprises:
an ultrasonic transmitter attached to the support system; and
an ultrasonic receiver attached to the support system, wherein the support system is wearable.
3. The system, as recited in claim 1 , wherein the ultrasonic transmitter and receiver system is an integrated wearable unit that uses an ultrasonic transceiver to both transmit and receive.
4. The system, as recited in claim 3 , wherein the ultrasonic imaging system further comprises a remote computer system, comprising:
a processor in the remote computer system, comprising; and
non-transient computer readable media, comprising:
computer readable code for receiving data from the processor of the controller;
computer readable code for determining a location of blood vessels in a patient;
computer readable code for providing Doppler analysis data from the received data; and
computer readable code for determining circulating tumor cell flow per volume flow of blood.
5. The system, as recited in claim 4 , wherein the remote computer system, further comprises computer readable code for creating an image from the Doppler analysis data and the circulating tumor cell imaging agent data.
6. The system, as recited in claim 5 , wherein the remote computer system is a wireless communications device.
7. The system, as recited in claim 1 , wherein the non-transient computer readable media further comprises computer readable code for providing blood flow data from the received signals from the patient.
8. The system, as recited in claim 7 , wherein the blood flow data comprises volume of blood flow within a blood vessel data.
9. The system, as recited in claim 1 , wherein the ultrasonic imaging system further comprises a remote computer system, comprising:
computer readable code for receiving data from the processor;
computer readable code for determining a location of blood vessels in a patient;
computer readable code for providing Doppler analysis data from the received data; and
computer readable code for determining circulating tumor cell flow per volume flow of blood.
10. The system, as recited in claim 1 , wherein the imaging agent injector, comprises:
a microbubble reservoir containing the microbubbles;
an injector in fluid communication with the microbubble reservoir;
a motor for moving microbubbles from the microbubble reservoir to the injector;
an injector controller for controlling the motor; and
at least one battery adapted to power the injector, the motor, and the injector controller, wherein the imaging agent injector is wearable.
11. The system, as recited in claim 1 , wherein the computer readable code for determining the number of circulating tumor cells in a location of detection of the patient determines the number of circulating tumor cells in a plurality of blood vessels at the location of detection.
12. The system, as recited in claim 1 , wherein the computer readable code for determining the presence of in vivo circulating tumor cells from the received ultrasonic signals from the patient determines the presence of in vivo circulating tumor cells after microbubbles not bound to circulating tumor cells are flushed out of the patient.