INJECTABLE MONOPHASE HYDROGELS
An injectable monophase hydrogel is provided and is made of a reaction mixture of a high molecular weight hyaluronic acid and a low molecular weight hyaluronic acid.
1 . An injectable product useful as a filling material in plastic or cosmetic surgery, the hydrogel comprising:
a homogenous, monophase injectable hydrogel comprising crosslinked hyaluronic acid and made from a reaction mixture comprising a low molecular weight hyaluronic acid and a high molecular weight hyaluronic acid.
2 . The product of claim 1 wherein the low molecular weight hyaluronic acid has a molecular weight m of ≦9.9×10 5 Da.
3 . The product of claim 1 wherein the low molecular weight hyaluronic acid has a molecular weight m of 10 4 Da≦m 9.9×10 5 Da.
4 . The product of claim 1 wherein the high molecular weight hyaluronic acid has a molecular weight M of ≧10 6 Da.
5 . The product of claim 1 wherein the high molecular weight hyaluronic acid has a molecular weight M of 10 6 Da≦M≦10 8 Da.
6 . The product of claim 1 wherein the high molecular weight hyaluronic acid has a molecular weight M of 1.1×10 6 Da≦M≦5×10 6 Da.
7 . The product of claim 1 wherein the reaction mixture has an intrinsic viscosity of less than 1900 ml/g.
8 . The product of claim 1 wherein the reaction mixture contains more than 50% by weight of the low molecular weight hyaluronic acid.
9 . The product of claim 1 wherein the reaction mixture contains more than 70% by weight of the low molecular weight hyaluronic acid.
10 . The product of claim 1 wherein the reaction mixture contains 90% by weight of the low molecular weight hyaluronic acid.
11 . The product of claim 1 wherein the reaction mixture contains at least 5% by weight of the high molecular weight hyaluronic acid.
12 . The product of claim 1 that is manually injectable through a hypodermic needle having a needle gauge selected from one of 30 G, 27 G, 26 G and 25 G.
13 . The product of claim 1 that is injectable through a hypodermic needle of 27 G.
14 . The product of claim 1 having a hyaluronic acid concentration between 10 mg/g and 40 mg/g.
15 . The product of claim 1 having a hyaluronic acid concentration between 20 mg/g and 30 mg/g.
16 . An injectable composition useful as a filling material in plastic or cosmetic surgery, the composition comprising:
a homogenous, monophase injectable hydrogel comprising a crosslinked hyaluronic acid;
the hydrogel made using a mixture containing at least 50% of a low molecular weight hyaluronic acid salt and a sufficient amount of a high molecular weight hyaluronic acid salt to obtain a coherent crosslinked compostion that is the precursor of the monophase injectable hydrogel.
17 . The composition of claim 16 wherein the hydrogel has a hyaluronic acid concentration between 10 mg/g and 40 mg/g.
18 . The composition of claim 17 wherein the mixture contains at least 5% by weight of the high molecular weight hyaluronic acid salt.
19 . The composition of claim 17 that is manually injectable through a hypodermic needle having a needle gauge selected from one of 30 G, 27 G, 26 G and 25 G.
20 . The composition of claim 17 that is injectable through a hypodermic needle of 27 G.