Polymer particles
Polymer particle embolics and methods of making same are described. The particle embolics can be used as embolization agents.
1. A method of making a spherical polymer particle comprising:
reacting an aqueous based prepolymer solution including at least one derivatized polyether macromer and an initiator in an oil to form the spherical polymer particle;
wherein said spherical polymer particle has a diameter less than about 1,200 μm.
2. The method of claim 1 , wherein the oil is a mineral oil.
3. The method of claim 1 , wherein the initiator is ammonium persulfate, tetramethylethylene diamine, or a combination thereof.
4. The method of claim 1 , wherein the polymer particle has a diameter between about 40 μm and about 1,200 μm.
5. The method of claim 1 , wherein the at least one derivatized polyether macromer is a derivative of poly(ethylene glycol), poly(propylene glycol), poly(tetramethylene oxide), or a combination thereof.
6. The method of claim 5 , wherein the at least one derivatized polyether macromer is poly(ethylene glycol) diacrylamide, poly(ethylene glycol) diacrylate, poly(ethylene glycol) dimethacrylate, poly(ethylene glycol) dimethacrylamide, or a combination thereof.
7. The method of claim 5 , wherein the at least one derivatized polyether macromer is poly(ethylene glycol) diacrylamide 10,000.
8. The method of claim 1 , further comprising at least one monomer.
9. The method of claim 8 , wherein the at least one monomer is glycerol monomethacrylate, amino ethyl methacrylate, 3-sulfopropyl acrylate, amino propyl methacrylamide, or a combination thereof.
10. The method of claim 8 , wherein the monomer is not n-isopropyl acrylamide.