Method for modulating canonical Wnt pathway using folate and inositol
The canonical Wnt signaling pathway is implicated in wound healing. Administration of a composition having myo-inositol and folic acid upregulates fibronectin and provides the greatest protection in an additive/synergistic manner against adverse Wnt/β-catenin-mediated effects on cell processes relating to cell differentiation, proliferation, and migration that relate to wound healing.
1. A method of upregulating fibronectin in a wound of a patient by administering a therapeutically effective combination consisting essentially of a folate compound and an inositol compound to a patient in need thereof.
2. The method of claim 1 , wherein the folate compound is folic acid.
3. The method of claim 1 , wherein the inositol compound is myo-inositol.
4. A method of treating a wound of a patient by administering a therapeutically effective combination consisting essentially of a folate compound and an inositol compound to a patient in need thereof.
5. The method of claim 4 , wherein the wound is a cutaneous wound.
6. The method of claim 4 , wherein the folate compound is folic acid.
7. The method of claim 4 , wherein the inositol compound is myo-inositol.
8. A method of accelerating wound healing in a wound of a patient by administering a therapeutically effective combination consisting essentially of a folate compound and an inositol compound to a patient in need thereof.
9. The method of claim 8 , wherein the folate compound is folic acid.
10. The method of claim 8 , wherein the inositol compound is myo-inositol.