Method to treat functional somatic syndromes with combination of aciclovir and celecoxib
The present invention relates to pharmaceutical compositions comprising a combination of a therapeutically-effective amount of the antiviral compound aciclovir and a therapeutically-effective amount of the COX-2 inhibitor celecoxib. The invention is further related to methods of treating functional somatic syndromes by administering a therapeutically-effective combination of aciclovir and celecoxib.
1. A method to treat a subject susceptible to or afflicted with one or more functional somatic syndrome conditions comprising: fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, chronic pain, chronic headache, chronic neck pain, chronic back pain, chronic depression, chronic clinical anxiety disorder, post-traumatic stress disorder (PTSD), brain fog, cognitive dysfunction and chronic interstitial cystitis, the method comprising administering to the subject a therapeutically-effective combination of aciclovir and celecoxib, wherein the amount of aciclovir is administered in a total daily dose range from about 400 mg to about 1600 mg, and wherein the amount of celecoxib is administered in a total daily dose range from about 200 mg to about 800 mg, and wherein the combination administered produces no substantial adverse event.
2. The method of claim 1 , wherein the condition is selected from the group consisting of fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, chronic depression, chronic clinical anxiety disorder and chronic interstitial cystitis.
3. The method of claim 1 , wherein the condition is fibromyalgia.
4. The method of claim 1 , wherein the condition is chronic fatigue syndrome.
5. The method of claim 1 , wherein the condition is irritable bowel syndrome.
6. The method of claim 1 , wherein the condition is a combination of fibromyalgia, chronic fatigue syndrome and irritable bowel syndrome, coexistent in the subject.
7. The method of claim 1 , wherein the amount of aciclovir is administered in a total daily dose range from about 400 mg to about 1200 mg, and wherein the amount of celecoxib is administered in a total daily dose range from about 200 mg to about 500 mg.
8. The method of claim 1 , wherein the amount of aciclovir administered in a total daily dose is about 800 mg, and wherein the amount of celecoxib administered in a total daily dose is about 400 mg.
9. The method of claim 8 , wherein the condition is fibromyalgia.