METHOD AND COMPOSITION FOR TISSUE/CELL REPAIR
The method and composition for tissue/cell repair facilitates healing of damaged tissues, promoting tissue and cell growth, protecting cells and tissues, and reducing scar tissue. The composition includes hydrolyzed collagen, preferably, high molecular weight hydrolyzed collagen. The hydrolyzed collagen may be combined with native collagen and/or at least one other therapeutic agent. For example, the therapeutic agent may be a polysulfated glycosaminoglycan, a glucosamine salt, or mixtures thereof.
1 . A composition for tissue/cell repair, comprising:
hydrolyzed collagen,
native collagen, and
at least one antioxidant selected from the group consisting of lipoic acid, a vitamin, an omega compound, an omega-3-fatty acid compound, an antioxidant, and a phytochemical,
wherein the hydrolyzed collagen is high molecular weight collagen, the high molecular weight collagen having a molecular weight between 10,000 Daltons and 300,000 Daltons.
2 . The composition according to claim 1 , wherein the composition comprises:
about 1% by weight to about 99% by weight hydrolyzed collagen; and
about 0.1% to about 65% by weight native collagen.
3 . (canceled)
4 . The composition according to claim 2 , wherein the high molecular weight collagen has a molecular weight between 10,000 Daltons and 95,000 Daltons.
5 . The composition according to claim 2 , wherein the native collagen comprises soluble collagen.
6 . The composition according to claim 2 , wherein the native collagen comprises insoluble native collagen.
7 . The composition according to claim 2 , further comprising a glycosaminoglycan selected from the group consisting of chondroitin sulfate, keratin sulfate, dermatic sulfate, hyaluronic acid, heparin, and heparin sulfate.
8 . The composition according to claim 2 , further comprising an antibiotic selected from the group consisting of tetracycline, streptomycin, and cephalosporin.
9 . The composition according to claim 2 , further comprising an antibacterial agent selected from the group consisting of iodine, parachlorometaxylenol, and chlorhexidine gluconate, and chlorhexidine acetate.
10 . (canceled)
11 . The composition according to claim 2 , wherein the composition is in a topical application form selected from the group consisting of a gel, a spray, a powder, a paste, a foam and a film.
12 . The composition according to claim 2 , wherein the composition is in liquid form.
13 . The composition according to claim 2 , wherein the hydrolyzed collagen is derived from at least one collagen source selected from the group consisting of a bovine source, a porcine source, a fish source, an avian source, and a synthetic source.
14 . The composition according to claim 13 , wherein the fish source comprises at least one fish selected from the group consisting of salmon and tilapia.
15 . A method of making a composition for tissue/cell repair, comprising:
deriving a first amount of native collagen from a collagen source;
hydrolyzing the first amount of native collagen to form a degraded collagen;
fractionating the degraded collagen to provide collagen fractions;
purifying the degraded collagen to form a high molecular weight hydrolyzed collagen having a molecular weight between 10,000 Daltons and 300,000 Daltons; and
combining the high molecular weight hydrolyzed collagen with a second amount of native collagen to form a composition for tissue/cell repair;
wherein the first amount of native collagen and the second amount of native collagen are derived from a collagen source selected from the group consisting of a bovine source, a porcine source, a fish source, an avian source, and a synthetic source.
16 . The method of making a composition for tissue/cell repair according to claim 15 , wherein the native collagen is derived from more than one collagen source.
17 . The method of making a composition for tissue/cell repair according to claim 15 , wherein the high molecular weight collagen has a molecular weight between 10,000 Daltons and 95,000 Daltons.
18 . The method of making a composition for tissue/cell repair according to claim 15 , wherein the hydrolyzed collagen is derived from at least one source selected from the group consisting of a bovine source, a porcine source, a fish source, an avian source, and a synthetic source.
19 . A method for tissue/cell repair, comprising the step of administering a composition to a site of tissue/cell injury, the composition including between 1% by weight and 99% by weight hydrolyzed collagen, and between 0.1% by weight and 65% by weight native collagen.
20 . The method for tissue/cell repair according to claim 19 , wherein the hydrolyzed collagen is high molecular weight hydrolyzed collagen having a molecular weight between 10,000 Daltons and 300,000 Daltons.