IP Library Granted Patent US 9,006,245
Granted Patent B2
US 9,006,245 · App. 14/547,804 · Granted Apr 14, 2015

Liver X receptor modulators

Inventors: Katerina Leftheris (San Diego, CA); Linghang Zhuang (Chalfont, PA)
Assignee: Vitae Pharmaceuticals, Inc.
C07D487/04A61K31/4985
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Quick Facts
Patent No.
US 9,006,245
App. No.
14/547,804
Granted
Apr 14, 2015
Kind
B2
Abstract

Provided herein are novel compounds and pharmaceutically acceptable salts thereof that are liver X receptor modulators. Also provided are compositions comprising compounds of the invention and a carrier. Additionally, use of the compounds herein and methods for treating a disease or disorder associated with the liver X receptor are further described.

Claims (15)

1. A compound of the formula:

or a pharmaceutically acceptable salt thereof.

2. A compound of the formula:

or a pharmaceutically acceptable salt thereof.

3. A pharmaceutical composition comprising a compound of the formula:

or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier or diluent.

4. The pharmaceutical composition of claim 3 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

5. A method of treating a subject with dermatitis, comprising administering to the subject an effect amount of a compound of the formula:

or a pharmaceutically acceptable salt thereof.

6. The method of claim 5 , wherein the compound is of the formula:

or a pharmaceutically acceptable salt thereof.

7. The method of claim 6 , wherein the dermatitis is contact dermatitis.

8. The method of claim 6 , wherein the dermatitis is eczema.

9. The method of claim 6 , wherein the dermatitis is atopic dermatitis.

Assignments (2)
CHANGE OF NAME Recorded Mar 20, 2019
From: VITAE PHARMACEUTICALS, INC.
To: VITAE PHARMACEUTICALS, LLC
Reel/Frame 050150/0044 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 19, 2014
From: LEFTHERIS, KATERINA; ZHUANG, LINGHANG
To: VITAE PHARMACEUTICALS, INC.
Reel/Frame 034211/0724 →
Continuity (3)
Continuation 14385688
Provisional Application 61612051 · Mar 16, 2012
Related Publication 20150080406A1 · Mar 19, 2015