Methods for treating heart arrhythmia
Methods and apparatus are provided for treatment of heart arrhythmia via renal neuromodulation. Such neuromodulation may effectuate irreversible electroporation or electrofusion, ablation, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, such neuromodulation is achieved through application of an electric field. In some embodiments, such neuromodulation is achieved through application of neuromodulatory agents, of thermal energy and/or of high intensity focused ultrasound. In some embodiments, such neuromodulation is performed in a bilateral fashion.
1. A method for treating heart arrhythmia in a patient in need thereof, the method comprising:
introducing a modulation instrument proximate a first neural fiber that contributes to renal function of a first kidney of the patient, the modulation instrument comprising a catheter comprising an inflatable balloon and electrodes attached to the inflatable balloon; and
delivering energy to the first neural fiber via the modulation instrument in order to modulate a function of the first neural fiber, thereby systemically reducing sympathetic tone in the patient.
2. The method of claim 1 , wherein delivering energy further comprises delivering an electric field.
3. The method of claim 2 , wherein delivering the electric field further comprises delivering a pulsed electric field.
4. The method of claim 1 , wherein modulating the function of the first neural fiber further comprises at least partially denervating the first kidney.
5. The method of claim 1 , wherein modulating the function of the first neural fiber further comprises ablating the first neural fiber.
6. The method of claim 1 , wherein delivering energy further comprises delivering thermal energy.
7. The method of claim 1 , wherein systemically reducing sympathetic tone in the patient further comprises decreasing a load on a heart of the patient.
8. A method for treating heart arrhythmia in a patient in need thereof, the method comprising:
introducing a modulation instrument proximate a first neural fiber that contributes to renal function of a first kidney of the patient, the modulation instrument comprising a catheter comprising an inflatable balloon and electrodes attached to the inflatable balloon; and
delivering energy to the first neural fiber via the modulation instrument in order to modulate a function of the first neural fiber, thereby decreasing a load on a heart of the patient.
9. The method of claim 8 , wherein delivering energy further comprises delivering an electric field.
10. The method of claim 9 , wherein delivering the electric field further comprises delivering a pulsed electric field.
11. The method of claim 8 , wherein modulating the function of the first neural fiber further comprises at least partially denervating the first kidney.
12. The method of claim 8 , wherein modulating the function of the first neural fiber further comprises ablating the first neural fiber.
13. The method of claim 8 , wherein delivering the energy further comprises delivering thermal energy.
14. The method of claim 8 , wherein decreasing the load on the heart of the patient further comprises systemically reducing sympathetic tone in the patient.
15. The method of claim 1 , wherein treating heart arrhythmia further comprises treating heart arrhythmia chosen from the group consisting of atrial arrhythmia, ventricular arrhythmia, tachycardia, bradycardia, atrial tachycardia, atrial fibrillation, atrial flutter, supraventricular tachycardia, Wolff-Parkinson-White syndrome, ventricular tachycardia, ventricular fibrillation, long QT syndrome, sick sinus, conduction block and combinations thereof.
16. The method of claim 8 , wherein treating heart arrhythmia further comprises treating heart arrhythmia chosen from the group consisting of atrial arrhythmia, ventricular arrhythmia, tachycardia, bradycardia, atrial tachycardia, atrial fibrillation, atrial flutter, supraventricular tachycardia, Wolff-Parkinson-White syndrome, ventricular tachycardia, ventricular fibrillation, long QT syndrome, sick sinus, conduction block and combinations thereof.
17. The method of claim 1 , wherein treating heart arrhythmia further comprises treating atrial fibrillation.
18. The method of claim 8 , wherein treating heart arrhythmia further comprises treating atrial fibrillation.
19. The method claim 1 , wherein the electrodes are configured to provide a bipolar signal.
20. The method of claim 1 , wherein the electrodes are affixed to an outside surface of the inflatable balloon.
21. The method claim 8 , wherein the electrodes are configured to provide a bipolar signal.
22. The method of claim 8 , wherein the electrodes are affixed to an outside surface of the inflatable balloon.
23. The method of claim 1 , wherein introducing a modulation instrument proximate a first neural fiber that contributes to renal function of a first kidney of a patient comprises introducing the modulation instrument into a first renal artery of the patient.
24. The method of claim 23 , further comprising introducing the modulation instrument into a second renal artery of a patient and proximate a second neural fiber that contributes to renal function of a second kidney of the patient.
25. The method of claim 8 , wherein introducing a modulation instrument proximate a first neural fiber that contributes to renal function of a first kidney of a patient comprises introducing the modulation instrument into a first renal artery of the patient.
26. The method of claim 25 , further comprising introducing the modulation instrument into a second renal artery of a patient and proximate a second neural fiber that contributes to renal function of a second kidney of the patient.