Device, system, and method for assessing intravascular pressure
What is described is an apparatus for intravascular pressure measurement, comprising an elongate body, a first pressure sensor and a centering assembly disposed adjacent the sensor. In one aspect, the elongate body has a uniform diameter from the distal end to the proximal end. In another aspect, the uniform diameter is 0.035 inches or less. In still a further aspect, the elongated body is a catheter having a plurality of reinforcing filaments and the filaments are utilized to electrically connect the sensor to the proximal end.
1. An apparatus for intravascular pressure sensing, comprising:
an elongate body having an outer surface, a proximal portion, and a distal portion, the elongate body being sized and shaped to be inserted into a vessel, the elongate body defining a lumen extending from the proximal portion to the distal portion of the elongate body, the lumen sized and shaped to allow the passage of a guidewire therethrough, the elongate body including two or more cylindrical layers extending from the lumen to the outer surface of the elongate body, wherein the two or more cylindrical layers comprise an inner cylindrical layer and an outermost cylindrical layer arranged around the inner cylindrical layer, wherein the elongate body includes a conductive filament arranged around the lumen and extending between the inner cylindrical layer and the outermost cylindrical layer from the distal portion of the elongate body to the proximal portion of the elongate body;
a pressure sensor disposed within the outermost cylindrical layer of the two or more cylindrical layers at the distal portion of the elongate body; and
an electronic component integrated within the elongate body at the proximal portion,
wherein the conductive filament establishes electrical connection with the pressure sensor through the outermost cylindrical layer at the distal portion of the elongate body to transmit an electrical signal representative of a sensed pressure from the distal portion to the electronic component.
2. The apparatus of claim 1 , further including a processing assembly disposed within the elongated body.
3. The apparatus of claim 1 , wherein the lumen includes a diameter of 0.014 inches or greater.
4. The apparatus of claim 1 , further including a steering mechanism to deflect a distal tip of the elongate body.
5. The apparatus of claim 4 , further including a proximal centering actuator joined to a centering assembly and a proximal steering actuator joined to the steering mechanism.
6. The apparatus of claim 1 , wherein the elongate body has an outer diameter of 0.035 inches or less for an entire length of the elongate body.
7. The apparatus of claim 1 , wherein the conductive filament is connected to the pressure sensor via a conductor.
8. The apparatus of claim 1 , wherein the conductive filament is encapsulated by an insulating polymer.
9. The apparatus of claim 8 , wherein the encapsulated filament forms a cylindrical layer around the lumen.
10. The apparatus of claim 1 , further comprising:
a centering assembly disposed adjacent to the pressure sensor, the centering assembly including a plurality of wires, each of the plurality of wires being positioned within one of a plurality of elongate channels defined in an outer surface of the elongate body, a distal end of each of the plurality of wires being anchored to a distal portion of one of the plurality of elongate channels, each of the plurality of wires extending proximally through and slidable within a tubular lumen in the elongate body, wherein the plurality of wires are outwardly deformable to engage a vessel wall.
11. The apparatus of claim 10 , wherein the centering assembly is switchable between a first position where the plurality of wires are disposed within the plurality of elongate channels and a second position where a portion of each of the plurality of wires deforms outwardly from the plurality of elongate channels to engage a vessel wall to center the sensor within the vessel.
12. The apparatus of claim 11 , wherein each of the plurality of wires includes a distal end and a proximal end and each of the plurality of elongate channels includes a distal portion, the distal end of each of the plurality of wires being anchored to the distal portion of one of the plurality of elongate channels.
13. The apparatus of claim 12 , wherein the proximal ends of the plurality of wires are coupled to a knob, the knob being slidable along a longitudinal direction of the elongate body between a deployment position where the centering assembly is switched to the first position and a withdrawal position where the centering assembly is switched to the second position.
14. The apparatus of claim 1 , wherein the conductive filament is electrically connected to the pressure sensor via a conductor extending through the outermost layer.
15. The apparatus of claim 1 , wherein the conductive filament is a first conductive filament positioned within an intermediate cylindrical layer between the outermost cylindrical layer and the inner cylindrical layer, and wherein the elongate body further comprises a second conductive filament positioned within the outermost layer, wherein the first conductive filament and the second conductive filament establish electrical contact with the pressure sensor.
16. The apparatus of claim 15 , wherein the elongate body further comprises a third conductive filament positioned within the inner cylindrical layer and establishing an electrical connection with the pressure sensor through the intermediate cylindrical layer and the outermost cylindrical layer.
17. A method, comprising
advancing a guidewire through a vessel to an area of interest;
positioning a sensing catheter over the guidewire, the sensing catheter including a sensor positioned adjacent a distal portion of the sensing catheter, a lumen, an electronic component integrated within a proximal portion of the sensing catheter, and wherein the sensing catheter includes two or more cylindrical layers comprising an inner cylindrical layer and an outermost cylindrical layer arranged around the inner cylindrical layer, wherein the sensing catheter includes a conductive filament arranged around the lumen and extending between the inner cylindrical layer and the outermost cylindrical layer from the distal portion of the sensing catheter to the electronic component, wherein the sensor is disposed within the outermost cylindrical layer at the distal portion of the sensing catheter, and wherein the conductive filament establishes electrical connection with the sensor through the outermost cylindrical layer at the distal portion of the sensing catheter;
advancing the sensing catheter over the guidewire to position the sensor in the area of interest;
sensing characteristics of the vessel in the area of interest;
transmitting data associated with the sensed characteristics of the vessel using the conductive filament from the sensor adjacent the distal portion to the electronic component; and
advancing a treating catheter over the sensing catheter to the area of interest.
18. The method of claim 17 , wherein sensing characteristics includes sensing at least one of pressure, fluid flow or images.
19. The method of claim 17 , wherein advancing the sensing catheter over the guidewire further includes positioning the sensing catheter and guidewire in a first position within a vessel, activating a catheter steering mechanism to deflect a tip of the sensing catheter and guidewire, advancing the guidewire to a second position within the vessel, and advancing the sensing catheter over the guidewire to the second position within the vessel.
20. The method of claim 17 , further comprises:
prior to sensing characteristics of the vessel in the area of interest, centering the sensor within the vessel by deploying a centering assembly disposed adjacent the sensor, wherein the centering assembly includes a plurality of wires, each of the plurality of wires being positioned within one of a plurality of elongate channels around a circumference of the sensing catheter, wherein the plurality of wires are outwardly deformable to engage a vessel wall of the vessel.
21. The method of claim 17 , wherein the proximal portion has a diameter identical to a diameter of the distal portion.