IP Library › Patent Application 14567740
Patent Application
App. No. 14/567,740

PHARMACEUTICAL COMPOSITIONS COMPRISING DGLA, 15-OHEPA, AND/OR 15-HETRE AND METHODS OF REDUCING SEBUM PRODUCTION USING SAME

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Quick Facts
Patent No.
US None
App. No.
14/567,740
Abstract

The present disclosure provides compositions comprising fatty acids, or derivatives thereof (e.g., C1-C4 esters) including, for example, DGLA, 15-OHEPA and/or 15-HETrE, used singly or in combination with anti-bacterial agents for the inhibition of sebum production.

Claims (14)

1 . A pharmaceutical composition comprising 15-HETrE and a retinoid analogue.

2 . The pharmaceutical composition of claim 1 wherein the retinoid analogue is adapalene.

3 . A topically deliverable pharmaceutical composition comprising a therapeutically effective amount of 15-HETrE and a retinoid analogue.

4 . The topically deliverable composition of claim 3 wherein the retinoid analogue is adapalene.

5 . The pharmaceutical composition of claim 2 , wherein the pharmaceutical composition comprises about 0.05 wt. % to about 0.3 wt. % of adapalene.

6 . The pharmaceutical composition of claim 2 , wherein the pharmaceutical composition comprises about 0.01 wt. % to about 20 wt. % of 15-HETrE.

7 . The pharmaceutical composition of claim 1 , wherein the composition is a cream.

8 . A method of treating or inhibiting development of acne in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of the pharmaceutical composition of claim 1 .

9 . The method of claim 8 , wherein the step of administering comprises applying the pharmaceutical composition to an area of skin of the subject afflicted with acne lesions.

10 . The method of claim 8 , wherein the acne is associated with Propionibacterium acnes.

11 . The method of claim 8 , wherein the pharmaceutical composition is administered to the subject once a day, twice a day, or three times a day.

12 . The method of claim 8 , wherein the pharmaceutical composition is a cream.

13 . The method of claim 8 , wherein the pharmaceutical composition comprises about 0.1 wt. % to about 20 wt. % of 15-HETrE.

14 . The method of claim 8 , wherein the pharmaceutical composition comprises about 0.05 wt. % to about 0.3 wt. % of adapalene.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 31, 2016
From: MANKU, MEHAR; COUGHLAN, DAVID; DOWNES, BILL; CLIMAX, JOHN
To: DIGNITY SCIENCES LIMITED
Reel/Frame 039598/0100 →