Methods and agents for the treatment of cancer
There are disclosed methods for prophylaxis or treatment of cancer in a mammal. The methods comprise administering an effective amount of an agent to the mammal, which binds to a MAP kinase or an integrin such that binding of the MAP kinase to the integrin is inhibited.
1. A polypeptide comprising amino acid sequence KEKLKNPLFK (SEQ ID No. 10), wherein the polypeptide is 40 amino acids in length or less.
2. The polypeptide according to claim 1 , consisting of amino acid sequence KEKLKNPLFK (SEQ ID No: 10).
3. The polypeptide according to claim 1 wherein the polypeptide binds to ERK2 MAP kinase.
4. An agent comprising the polypeptide according to claim 1 , coupled to a facilitator moiety for facilitating passage of the polypeptide across the outer cell membrane of cells.
5. The agent according to claim 4 wherein the facilitator moiety is selected from a group consisting of a carrier peptide and a lipid moiety.
6. The agent according to claim 4 being a fusion protein comprising the polypeptide and the facilitator moiety.
7. A pharmaceutical composition comprising a polypeptide according to claim 1 together with a pharmaceutically acceptable carrier or excipient.
8. A pharmaceutical composition comprising an agent according to claim 4 together with a pharmaceutically acceptable carrier or excipient.