METHODS OF TREATING NEUROPATHIC PAIN
The disclosure relates, at least in part, to methods of treating neuropathic pain in a patient in need thereof by administering an effective amount of a disclosed compound, e.g. a peptide NMDA receptor partial agonist.
1 . A method for treating neuropathic pain in a patient in need thereof, comprising administering to said patient a pharmaceutically effective amount of a peptide that modulates a glycine site on a NMDA receptor.
2 . The method of claim 1 , wherein the neuropathic pain is associated with a condition selected from the group consisting of herpes, HIV, traumatic nerve injury, stroke, post-ischemia, fibromyalgia, reflex sympathetic dystrophy, complex regional pain syndrome, spinal cord injury, sciatica, phantom limb pain, diabetic neuropathy, and cancer chemotherapeutic-induced neuropathic pain.
3 . The method of claim 1 , wherein the NMDA receptor modulating peptide is represented by:
or pharmaceutically acceptable salts thereof.
4 . The method of claim 1 , wherein the peptide is administered intravenously, intraperitoneally, intramuscularly, or subcutaneously.
5 . The method of any one of claim 1 , wherein the method comprises administering a single-dose of said peptide.
6 . The method of any one of claim 1 , wherein about 1 day after administration the patient has substantial improvement in neuropathic pain.
7 . The method of any one of claim 1 , wherein about 8 days after administration the patient has substantial improvement in neuropathic pain.
8 . The method of any one of claim 1 , wherein the compound is administered daily.
9 . The method of any one of claim 1 , wherein upon said administration, the patient has no significant axatia.
10 . The method of any one of claim 1 , wherein the pharmaceutically effective amount is about 0.01 mg/kg to about 1000 mg/kg.
11 . A method of treating neuropathic pain in a patient in need thereof, comprising administering to said patient a single dose of a compound represented by:
or pharmaceutically acceptable salts thereof, wherein after 1 day the patient has substantial improvement in neuropathic pain.
12 . The method of claim 11 , wherein after 8 days the patient has substantial improvement in neuropathic pain.
13 . The method of claim 11 , wherein the single dose comprises about 0.01 mg/kg to about 1000 mg/kg.
14 . A method of treating neuropathic pain in a patient in need thereof, comprising administering to said patient an effective amount of SEQ ID. NO:13 (Thr-Pro-Pro-Thr).