Pediculicidal composition
The disclosure provides a pediculicidal composition comprising a metal chelating agent; a carrier vehicle comprising water and an activating solvent system comprising an alcohol and a hydrocarbon. The carrier vehicle may be in the form of a solution, a cream, an ointment, a foam, a spray, an emulsion or a gel. The disclosure also provides method for use of a pediculicidal composition to treat human head lice and their eggs and methods for controlling head lice infestation.
1. A composition comprising:
5,5′-dimethyl-2,2′-dipyridyl is present in an amount from 0.5% to 1% by weight;
benzyl alcohol is present in an amount from 1% to 3% by weight;
mineral oil is present in an amount from 20% to 30% by weight;
water is present in an amount from 60% to 90% by weight;
carbomer is present in an amount from 0.1% to 0.5% by weight;
trolamine is present in an amount from 0.1% to 1% by weight;
butylated hydroxy toluene is present in an amount from 0.2% to 1% by weight;
and polysorbate 20 is present in an amount from 0.5 to 1% by weight.
2. The composition of claim 1 , wherein said composition is a lotion, cream or gel composition comprising 0.74% by weight 5,5′-dimethyl-2,2′-dipyridyl.
3. The composition of claim 1 , wherein said composition is a lotion or gel composition comprising 24% by weight mineral oil.
4. The composition of claim 1 , wherein said composition is a lotion or gel composition comprising 2% by weight benzyl alcohol.
5. The composition of claim 1 , comprising 2% by weight benzyl alcohol, 24% mineral oil, 1% polysorbate 20 and 0.74%, 5,5′-dimethyl-2,2′-dipyridyl and said composition exhibits a greater lousicidal activity than a composition that comprises benzyl alcohol, mineral oil, and polysorbate 20 in the same weight percent, but that does not comprise 5,5′-dimethyl-2,2′-dipyridyl.
6. The composition of claim 1 , comprising 2% by weight benzyl alcohol, 24% mineral oil, 1% polysorbate 20 and 0.74%, 5,5′-dimethyl-2,2′-dipyridyl and said composition exhibits a greater ovicidal and lousicidal activity than a composition that comprises benzyl alcohol, mineral oil, and polysorbate 20 in the same weight percent, but that does not comprise 5,5′-dimethyl-2,2′-dipyridyl.
7. An aqueous composition for topical application to a subject comprising by weight: 0.74% 5,5′-dimethyl-2,2′-dipyridyl; 24% mineral oil; 0.15% Carbomer; 0.20% Trolamine; 2.00% benzyl alcohol, 1% polysorbate 20, 0.5% butylated hydroxytoluene and balance purified water.
8. A method of treating a lice infestation, the method comprising topically applying to a host having a lice infestation an effective amount of a composition according to claim 1 .
9. The method of claim 8 , wherein topical application of said composition kills lice and inhibits egg hatching.
10. The method of claim 8 , wherein topical application of said composition to said host kills more lice than a vehicle composition comprising the same components except for 5,5′-dimethyl 2,2′-dipyridyl.