Composition, synthesis, and use of new substituted pyran and pterin compounds
The present invention relates to substituted pterin compounds, their synthesis and use. In particular, the present invention relates to a new precursor compound and its analogs for synthesizing a new substituted pterin compound and its analogs. These new compounds are particularly suitable for treating molybdenum cofactor deficiency.
1. A compound of a structure selected from the group consisting of:
wherein X is selected from the group consisting of oxygen and sulfur and, R 1 and R 2 are each independently unsubstituted C 1 -C 6 alkyl.
2. A method of preparing a compound having a structure selected from the group consisting of:
wherein X is selected from the group consisting of oxygen and sulfur and, R 1 and R 2 are each independently unsubstituted C 1 -C 6 alkyl,
comprising:
starting with a precursor compound having a structure I:
wherein X is selected from the group consisting of oxygen and sulfur and, R 1 and R 2 are each independently unsubstituted C 1 -C 6 alkyl; and
combining the precursor compound having the structure I with 4-hydroxy-2,5,6-triaminopyrimidine sulfate in a condensation reaction to form the compound having a structure selected from the group consisting of IIIa and IIIb.
3. A therapeutic composition comprising the compound of claim 1 .
4. A method of treating molybdenum co-factor deficiency comprising administering a therapeutically effective amount of the compound of claim 1 .