Herbal composition PHY906 and its use in chemotherapy
This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.
1. A method of increasing the therapeutic index of sorafenib by administering to a mammal to which sorafenib has been administered a therapeutically effective amount of an herbal preparation comprising Scutellaria, Glycyrrhiza, Ziziphus , and Paeonia.
2. A method of treating cancer in a mammal in need thereof comprising administering to the mammal a therapeutically effective amount of:
i) an herbal preparation comprising Scutellaria, Glycyrrhiza, Ziziphus , and Paeonia ; and
iii) a chemotherapeutic formulation comprising sorafenib.
3. The method of claim 2 , wherein the cancer is a gastrointestinal cancer.
4. A method of relieving side effects of sorafenib in a mammal comprising administering to the mammal a therapeutically effective amount of:
i) an herbal preparation comprising Scutellaria, Glycyrrhiza, Ziziphus , and Paeonia ; and
iii) a chemotherapeutic formulation comprising sorafenib.
5. A method of enhancing therapeutic effectiveness of sorafenib in a mammal comprising administering to the mammal a therapeutically effective amount of:
i) an herbal preparation comprising Scutellaria, Glycyrrhiza, Ziziphus , and Paeonia ; and
iii) a chemotherapeutic formulation comprising sorafenib.
6. A method of using sorafenib, comprising administering to a mammal in need thereof a therapeutically effective amount of:
i) an herbal preparation comprising Scutellaria, Glycyrrhiza, Ziziphus , and Paeonia ; and
iii) a chemotherapeutic formulation comprising sorafenib.
7. A method of improving the quality of life of a mammal being treated with sorafenib comprising administering a therapeutically effective amount of a chemotherapeutic formulation comprising sorafenib and an herbal preparation comprising Scutellaria, Glycyrrhiza, Ziziphus , and Paeonia.
8. A method of inhibiting the growth of tumors comprising administering to a mammal in need thereof:
i) an herbal preparation comprising Scutellaria, Glycyrrhiza, Ziziphus , and Paeonia ; and
iii) a chemotherapeutic formulation comprising sorafenib.
9. The method of claim 8 , wherein the tumors are present in a mammal or in vitro cells.
10. The method of any one of claims, 1 , 2 , 4 , 5 , 6 , 7 , and 9 wherein the mammal is human.
11. The method of any one of the claims 1 , 2 , 4 , 5 , 6 , 7 , and 8 , wherein the herbal preparation comprises Scutellaria baicalensis, Glycyrrhiza uralensis, Ziziphus jujuba , and Paeonia lactiflora.
12. The method of any one of the claims 2 , 4 , 5 , 6 , 7 , and 8 , wherein the herbal preparation is administered via oral route and sorafenib is administered via oral route.
13. The method of claim 12 , wherein the herbal preparation is administered before sorafenib is administered.