IP Library › Granted Patent US 9,309,287
Granted Patent B2
US 9,309,287 · App. 14/581,752 · Granted Apr 12, 2016

Inhibitors of TLR signaling by targeting TIR domain interfaces

Inventor: Vladimir Toshchakov (Owings Mills, MD)
Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
C07K7/08C07K7/06C07K14/705
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 9,309,287
App. No.
14/581,752
Granted
Apr 12, 2016
Kind
B2
Abstract

TIR-domain decoy peptides and TIR domain peptides are disclosed, as well as methods of using the peptides in the regulation of toll-like receptor (TLR) activation and signaling.

Claims (43)

1. A TIR-derived decoy peptide selected from the group consisting of:

TRAP based, TIR-derived decoy peptides

TR3 (RQIKIWFQNRRMKWKKEGSQASLRCF; SEQ ID NO:1),

TR5 (RQIKIWFQNRRMKWKKELCQALSRSHCR; SEQ ID NO:2),

TR6 (RQIKIWFQNRRMKWKKPGFLRDPWCKYQML; SEQ ID NO:3),

TR9 (RQIKIWFQNRRMKWKKAAYPPELRFMYYVD; SEQ ID NO:4),

TR11 (RQIKIWFQNRRMKWKKGGFYQVKEAVIHY; SEQ ID NO:5),

TRAM based, TIR-derived decoy peptides

TM4-ΔC (RQIKIWFQNRRMKWKKIVFAEMPCG; SEQ ID NO:7),

TM6 (RQIKIWFQNRRMKWKKENFLRDTWCNFQFY; SEQ ID NO:8),

TRIF based, TIR-derived decoy peptides

TF5 (RQIKIWFQNRRMKWKKCLQDAIDHSGFT; SEQ ID NO:10),

TF5-ΔC (RQIKIWFQNRRMKWKKCLQDAIDHS; SEQ ID NO:11),

MyD88 based, TIR-derived decoy peptides

M3 (RQIKIWFQNRRMKWKKEQTDYRLKLC; SEQ ID NO:12),

M5 (RQIKIWFQNRRMKWKKIASELIEKRCRRM; SEQ ID NO:14),

TLR2 based, TIR-derived decoy peptides

2R1 (RQIKIWFQNRRMKWKKRKPKKAPCRDVCYD; SEQ ID NO:20),

2R3 (RQIKIWFQNRRMKWKKENSDPPFKLC; SEQ ID NO:21),

2R9 (RQIKIWFQNRRMKWKKPQRFCKLRKIMNT; SEQ ID NO:22),

and

2DD-αD (RQIKIWFQNRRMKWKKEPIERKAIPQRFCK; SEQ ID NO:24), and variants thereof having one or two amino acid changes, independently selected from additions, substitutions and deletions, in the TIR-domain segment of the peptide.

2. A TIR-derived decoy peptide selected from the group consisting of:

TIRAP based, TIR-derived decoy peptides

TR3 (RQIKIWFQNRRMKWKKEGSQASLRCF; SEQ ID NO: 1),

TR5 (RQIKIWFQNRRMKWKKELCQALSRSHCR; SEQ ID NO:2),

TR6 (RQIKIWFQNRRMKWKKPGFLRDPWCKYQML; SEQ ID NO:3),

TR9 (RQIKIWFQNRRMKWKKAAYPPELRFMYYVD; SEQ ID NO:4),

TR11 (RQIKIWFQNRRMKWKKGGFYQVKEAVIHY; SEQ ID NO:5),

TRAM based, TIR-derived decoy peptides

TM4-ΔC (RQIKIWFQNRRMKWKKIVFAEMPCG; SEQ ID NO:7),

TM6 (RQIKIWFQNRRMKWKKENFLRDTWCNFQFY; SEQ ID NO:8),

TRIF based, TIR-derived decoy peptides

TF5 (RQIKIWFQNRRMKWKKCLQDAIDHSGFT; SEQ ID NO: 10),

TF5-ΔC (RQIKIWFQNRRMKWKKCLQDAIDHS; SEQ ID NO: 11),

MyD88 based, TIR-derived decoy peptides

M3 (RQIKIWFQNRRMKWKKEQTDYRLKLC; SEQ ID NO: 12),

M5 (RQIKIWFQNRRMKWKKIASELIEKRCRRM; SEQ ID NO: 14),

TLR2 based, TIR-derived decoy peptides

2R1 (RQIK1WFQNRRMKWKKRKPKKAPCRDVCYD; SEQ ID NO:20),

2R3 (RQIK1WFQNRRMKWKKENSDPPFKLC; SEQ ID NO:21),

2R9 (RQIK1WFQNRRMKWKKPQRFCKLRKIMNT; SEQ ID NO:22), and

2DD-αD (RQIKIWFQNRRMKWKKEPIERKAIPQRFCK; SEQ ID NO:24).

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 20, 2015
From: TOSHCHAKOV, VLADIMIR
To: UNIVERSITY OF MARYLAND, BALTIMORE
Reel/Frame 034760/0548 →
CONFIRMATORY LICENSE Recorded Jan 12, 2015
From: UNIVERSITY OF MARYLAND BALTIMORE
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 034682/0529 →
Continuity (3)
Division 13761277 · Feb 7, 2013
Provisional Application 61595727 · Feb 7, 2012
Related Publication 20160039901A1 · Feb 11, 2016