Granted Patent B2

US 9,421,183 · App. 14/586,765 · Granted Aug 23, 2016

Inventors: Brian Cornblatt (Westminster, MD); Grace Cornblatt (Westminster, MD); Anton Bzhelyansky (Baltimore, MD); Robert Henderson (Street, MD)

Assignee: NUTRAMAX LABORATORIES, INC.

A61K31/26A23L1/3002A61K9/0053A61K9/28A61K31/19A61K31/194A61K31/357A61K31/375A61K31/7028A61K31/716A61K33/06A61K36/06A61K36/07A61K36/28A61K36/31A61K38/47A61K45/06A61K47/42C12Y302/01147A23V2002/00

Abstract

Claims (18)

1. An orally administrable composition comprising a synergistic combination of:

a sulforaphane precursor;

a glucosidase enzyme capable of converting the sulforaphane precursor to sulforaphane;

a cofactor of the enzyme; and

a maitake mushroom extract or powder.

2. The orally administrable composition of claim 1 , wherein the sulforaphane precursor comprises glucoraphanin.

3. The orally administrable composition of claim 1 , wherein the enzyme capable of converting the sulforaphane precursor to sulforaphane comprises myrosinase.

4. The orally administrable composition of claim 1 , wherein the enzyme cofactor comprises ascorbic acid.

5. The orally administrable composition of claim 1 , wherein the composition comprises an enteric-coated dosage form.

6. The orally administrable composition of claim 1 , wherein the composition further comprises one or more additional components selected from the group consisting of: quercetin, an aminosugar, a glycosaminoglycan, avocado/soybean unsaponifiables unsaponifiable, a vitamin, coffee fruit, magnesium, silymarin, proanthocyanidins, ursolic acid, curcumin, phytosterols, and phytostanols.

7. The orally administrable composition of claim 1 , comprising glucoraphanin, myrosinase, ascorbic acid, and maitake mushroom extract.

8. The orally administrable composition of claim 1 , wherein the composition comprises a broccoli extract or powder comprising the sulforaphane precursor.

9. A method of treating, preventing, reducing the occurrence of, decreasing the symptoms associated with, and reducing secondary recurrences of breast cancer, comprising administering to a subject in need thereof a composition comprising a synergistic combination of a sulforaphane precursor; a glucosidase enzyme capable of converting the sulforaphane precursor to sulforaphane; a cofactor of the enzyme; and a maitake mushroom extract or powder.

10. The method of claim 9 , wherein the sulforaphane precursor comprises glucoraphanin.

11. The method of claim 9 , wherein the enzyme capable of converting the sulforaphane precursor to sulforaphane comprises myrosinase.

12. The method of claim 9 , wherein the enzyme cofactor comprises ascorbic acid.

13. The method of claim 9 , comprising administration of glucoraphanin, myrosinase, ascorbic acid, and maitake mushroom extract.

14. The method of claim 9 , comprising administering an enteric-coated dosage form.

Assignments (1)

Continuity (9)