IP Library › Granted Patent US 9,138,426
Granted Patent B2
US 9,138,426 · App. 14/591,124 · Granted Sep 22, 2015

Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes

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Quick Facts
Patent No.
US 9,138,426
App. No.
14/591,124
Granted
Sep 22, 2015
Kind
B2
Abstract

The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

Claims (2)

1. A method of treating diabetes in a patient comprising administering to a patient in need thereof a therapeutically effective amount of a compound which is:

or a pharmaceutically acceptable salt thereof, in combination with amylin or an amylin analog.

Assignments (1)
MERGER Recorded Aug 8, 2022
From: MERCK SHARP & DOHME CORP.
To: MERCK SHARP & DOHME LLC
Reel/Frame 061102/0145 →