PHARMACEUTICAL COMPOSITIONS COMPRISING POH DERIVATIVES
The present invention provides for a perillyl alcohol (POH) carbamate, such as POH-Rolipram. The present invention also provides for a method of treating a disease such as cancer, by delivering to a patient a therapeutically effective amount of POH-Rolipram.
1 . A composition comprising a perillyl alcohol carbamate, wherein the perillyl alcohol carbamate comprises perillyl alcohol conjugated with rolipram.
2 . The composition of claim 1 , wherein the perillyl alcohol carbamate is 4-(3-cyclopentyloxy-4-methoxy phenyl)-2-oxo-pyrrolidine-1-carboxylic acid 4-isopropenyl cyclohex-1-enylmethyl ester.
3 . A method for treating a glioblastoma in a mammal, comprising delivering to the mammal a therapeutically effective amount of a perillyl alcohol carbamate, wherein the perillyl alcohol carbamate comprises perillyl alcohol conjugated with rolipram.
4 . The method of claim 3 , further comprising treating the mammal with radiation.
5 . The method of claim 3 , further comprising delivering to the mammal a chemotherapeutic agent.
6 . The method of claim 3 , wherein the perillyl alcohol carbamate is administered by inhalation, intranasally, orally, intravenously, subcutaneously or intramuscularly.
7 . The method of claim 6 , wherein the perillyl alcohol carbamate is administered intranasally using an atomizer.
8 . The method of claim 3 , wherein the perillyl alcohol carbamate is 4-(3-cyclopentyloxy-4-methoxy phenyl)-2-oxo-pyrrolidine-1-carboxylic acid 4-isopropenyl cyclohex-1-enylmethyl ester.
9 . A method for treating a disease in a mammal, comprising administering to the mammal a therapeutically effective amount of a perillyl alcohol carbamate using a nasal delivery device, wherein the perillyl alcohol carbamate comprises perillyl alcohol conjugated with rolipram.
10 . The method of claim 9 , wherein the nasal delivery device is selected from the group consisting of an intranasal inhaler, an intranasal spray device, an atomizer, a nebulizer, a metered dose inhaler (MDI), a pressurized dose inhaler, an insufflator, a unit dose container, a pump, a dropper, a nasal spray bottle, a squeeze bottle and a bi-directional device.
11 . The method of claim 9 , wherein the disease is cancer.
12 . The method of claim 11 , wherein the cancer is a tumor of the nervous system.
13 . The method of claim 12 , wherein the tumor is a glioblastoma.
14 . The method of claim 9 , further comprising the step of treating the mammal with radiation.
15 . The method of claim 9 , further comprising the step of delivering to the mammal a chemotherapeutic agent.