Labeled alginate conjugates for molecular imaging applications
Described are bifunctional NOTA-based derivatives capable of conjugating with alginate and with metal ions, as well as NOTA-alginate conjugates which can be labeled with stable or radioactive metal ions. Also described are conjugation methods of the bifunctional NOTA-based linker with alginate, and methods of using radiometal-labeled NOTA-alginate conjugates or other radio-labeled alginate conjugates as imaging reagents.
1. A compound having the formula:
wherein X is —(CH 2 ) m C(O)—, with m being 1, 2, or 3;
L is a linker selected from the group consisting of:
wherein n, n′ and n″ are each independently a number from 0 to 10;
H is hydrogen; and
Y—H is:
wherein R is selected from the group consisting of hydrogen, alkyl, benzyl or an aromatic group;
or a pharmaceutically acceptable salt or solvate thereof.
2. The compound of claim 1 , wherein the compound further comprises a stable or radioactive metal ion chelated by the 1,4,7-triazacyclononane-1,4,7-triacetic acid moiety.
3. The compound of claim 2 , wherein the stable or radioactive metal ion comprises a gallium ion.
4. The compound of claim 2 , wherein the radioactive metal ion comprises 60 Cu, 61 Cu, 62 Cu, 64 Cu, 67 Cu, or 111 In.