Immunogenic composition and uses thereof
The present invention provides an immunogenic composition comprising an antigen and a dendritic cell targeting component. A charged group is covalently attached to a dendritic cell ligand and is electrostatically associated with the dendritic cell targeting component.
1. An immunogenic composition comprising a complex of a polypeptide antigen and a dendritic cell targeting component, wherein the polypeptide antigen comprises a negatively charged region, wherein the negatively charged region of the polypeptide antigen electrostatically associates with the dendritic cell targeting component, thereby enabling formation of the complex,
wherein the dendritic cell targeting component comprises:
and wherein Pam2Cys refers to dipalmitoyl-S-glycerylcysteine.
2. The immunogenic composition according to claim 1 , wherein the polypeptide antigen has an overall negative charge.
3. The immunogenic composition according to claim 1 , wherein the polypeptide antigen is associated with the dendritic cell targeting component by electrostatic interaction only.