Systems and methods for neuromodulation for treatment of disorders associated with nerve conduction
Methods and apparatus are provided for selective destruction or temporary disruption of nerves and/or conduction pathways in a mammalian body for the treatment of pain and other disorders. Apparatus comprises catheters having electrodes for targeting and affecting nerve tissue at a cellular level to reversible and irreversible nerve poration and incapacitation.
1. A method for treating a disorder associated with nerve conduction in a human patient, the method comprising:
advancing a catheter comprising one or more electrodes through an artery of the patient, wherein the one or more electrodes comprise a treatment electrode and a monitoring electrode;
delivering a first energy from the treatment electrode to a treatment area of nerve tissue of the patient, wherein the nerve tissue comprises nerves located adjacent to the artery of the patient, and wherein the first energy irreversibly disrupts the nerve tissue; and
after delivering the first energy, using the monitoring electrode to monitor the treatment area and thereby determine a degree of treatment achieved therein.
2. The method of claim 1 , wherein the treatment electrode and the monitoring electrode are the same electrode.
3. The method of claim 1 , wherein the nerve tissue comprises a nerve running directly along an outside of the artery of the patient.
4. The method of claim 1 , wherein the one or more electrodes are axially aligned on one side of the catheter.
5. The method of claim 1 , wherein the one or more electrodes have a ring structure.
6. The method of claim 1 , wherein the one or more electrodes are in a bipolar configuration.
7. The method of claim 1 , wherein the one or more electrodes are in a monopolar configuration.
8. The method of claim 1 , wherein the one or more electrodes comprise multiple pairs of electrodes.
9. The method of claim 8 , wherein the multiple pairs of electrodes may be activated in pairs.
10. The method of claim 8 , wherein the multiple pairs of electrodes may be activated in groups.
11. The method of claim 8 , wherein the multiple pairs of electrodes may be activated in a sequential manner.
12. The method of claim 1 , wherein the artery comprises a carotid artery.
13. The method of claim 1 , wherein the artery comprises a radial artery.
14. The method of claim 1 , wherein the nerve tissue comprises peripheral nerves.
15. The method of claim 1 , further comprising, in conjunction with delivering the first energy, modulating disruption of the nerve tissue using a nerve blocking agent, chemical or other therapeutic agent.
16. The method of claim 1 , wherein the first energy comprises electric energy.
17. The method of claim 1 , wherein the first energy comprises ultrasonic energy.
18. The method of claim 1 , further comprising injecting a therapeutic agent from the catheter before, during or after delivery or the first energy.
19. The method of claim 18 , wherein the therapeutic agent comprises a nerve blocking agent.
20. The method of claim 18 , wherein the therapeutic agent comprises lidocaine.
21. The method of claim 1 , further comprising delivering a second energy from the catheter while the catheter is in the artery, wherein the second energy stimulates the nerve tissue of the patient.
22. The method of claim 21 , further comprising observing a nerve reflex after delivery of the second energy, to localize the treatment area.