Pyrazole amide derivative
The present invention relates to a novel compound having a function of inhibiting RORγ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases.
1. A compound represented by formula (I) or a pharmaceutically acceptable salt thereof:
wherein:
R 1 is selected from F, Cl, Br, a C 1 to C 6 alkyl group substituted by 0, 1, 2 or 3 R a groups and a C 3 to C 8 cycloalkyl group substituted by 0, 1, 2 or 3 R a groups;
Y is selected from a C 4 to C 6 cycloalkyl group, a C 6 to C 9 bicycloalkyl group and a C 6 to C 9 spiroalkyl group, all of which are substituted by a R 2 group, 0 or 1 R 6 group and 0, 1, 2 or 3 R 7 groups;
R 2 is selected from —OH, —CO 2 H, —SO 3 H, —CONH 2 , —SO 2 NH 2 , a (C 1 to C 6 alkoxy)carbonyl group substituted by 0, 1, 2 or 3 R c groups, a (C 1 to C 6 alkyl)aminocarbonyl group substituted by 0, 1, 2 or 3 R c groups, a C 1 to C 6 alkylsulfonyl group substituted by 0, 1, 2 or 3 R c groups, a C 1 to C 6 alkylaminosulfonyl group substituted by 0, 1, 2 or 3 R c groups, a (hydroxycarbonyl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2 or 3 R c groups, a (C 1 to C 6 alkoxy)carbonyl(C 1 to C 3 alkyl) group substituted by 0, 1, 2 or 3 R c groups, a (C 1 to C 6 alkyl)sulfonyl(C 1 to C 3 alkyl) group substituted by 0, 1, 2 or 3 R c groups and a (C 2 to C 6 alkenyl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2 or 3 R c groups;
R 6 and R 7 are independently selected from H, F, —OH, —NH 2 , —CN, a C 1 to C 6 alkyl group substituted by 0, 1, 2 or 3 R b groups and a C 1 to C 6 alkoxy group substituted by 0, 1, 2 or 3 R b groups;
R 3 is selected from H, F, Cl, —CH 3 and —CF 3 ;
R 4 is selected from a C 1 to C 6 alkyl group substituted by 0, 1, 2, 3, 4 or 5 R e groups, a (C 2 to C 6 alkenyl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R e groups, a (C 2 to C 6 alkynyl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R e groups, a (C 1 to C 6 alkoxy)(C 2 to C 4 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R e groups, a (C 6 to C 10 aryl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R f groups, a (5- to 10-membered heteroaryl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R f groups, a C 3 to C 8 cycloalkyl group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a C 3 to C 8 cycloalkenyl group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a (C 3 to C 8 cycloalkyl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a (C 3 to C 8 cycloalkenyl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a 3- to 8-membered heterocycloalkyl group substituted by 0, 1, 2, 3, 4 or 5 R g groups and a (3- to 8-membered heterocycloalkyl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a C 6 to C 9 spiroalkyl group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a (C 6 to C 9 spiroalkyl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a C 6 to C 9 spiroheteroalkyl group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a C 5 to C 9 bicycloalkyl group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a (C 5 to C 9 bicycloalkyl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a C 6 to C 9 heterobicycloalkyl group substituted by 0, 1, 2, 3, 4 or 5 R g groups, and a (C 6 to C 9 heterobicycloalkyl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R g groups;
R 5 is selected from a C 6 to C 10 aryl group substituted by 0, 1, 2, 3, 4 or 5 R i groups, a 5- to 10-membered heteroaryl group substituted by 0, 1, 2, 3, or 4 R i groups, a C 3 to C 8 cycloalkyl group substituted by 0, 1, 2, 3, 4 or 5R j groups, a C 3 to C 8 cycloalkenyl group substituted by 0, 1, 2, 3, 4 or 5R j groups and a 3- to 8-membered heterocycloalkyl group substituted by 0, 1, 2, 3, 4 or 5 R j groups;
R 8 and R 9 are independently selected from H, F, —OH, —NH 2 , a C 1 to C 3 alkyl group substituted by 0, 1, 2 or 3 R h groups, and a C 1 to C 6 alkoxy group substituted by 0, 1, 2 or 3 R h groups; or R 8 and R 9 together form an oxo group or a thioxo group;
R 12 is H; or R 4 and R 12 together are —CR m R m —CR 13 R 14 —CR m R m — or —CR 13 R 14 —CR m R m —CR m R m — to form a pyrrolidine ring;
R 13 is selected from H, a C1 to C 6 alkyl group substituted by 0, 1, 2, 3, 4 or 5 R e groups, a C 6 to C 10 aryl group substituted by 0, 1, 2, 3, 4 or 5 R f groups, a C 6 to C 10 aryloxy group substituted by 0, 1, 2, 3, 4 or 5 R f groups, a (C 2 to C 6 alkenyl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R e groups, a (C 2 to C 6 alkynyl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R e groups, a (C 1 to C 6 alkoxy)(C 2 to C 4 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R e groups, a (C 6 to C 10 aryl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R f groups, a (5- to 10-membered heteroaryl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R f groups, a C 3 to C 8 cycloalkyl group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a C 3 to C 8 cycloalkenyl group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a (C 3 to C 8 cycloalkyl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a (C 3 to C 8 cycloalkenyl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a 3- to 8-membered heterocycloalkyl group substituted by 0, 1, 2, 3, 4 or 5 R g groups and a (3- to 8-membered heterocycloalkyl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a C 6 to C 9 spiroalkyl group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a (C 6 to C 9 spiroalkyl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a C 6 to C 9 spiroheteroalkyl group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a C 6 to C 9 bicycloalkyl group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a (C 5 to C 9 bicycloalkyl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a C 6 to C 9 heterobicycloalkyl group substituted by 0, 1, 2, 3, 4 or 5 R g groups, and a (C 6 to C 9 heterobicycloalkyl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R g groups;
R 14 is independently selected from H and a C 1 to C 6 alkyl group substituted by 0, 1, 2, 3, 4 or 5 R e groups; or R 13 and R 14 together form a C 3 to C 8 cycloalkane ring substituted by 0, 1, 2, 3, 4 or 5 R g groups, C 3 to C 8 cycloalkene ring substituted by 0, 1, 2, 3, 4 or 5 R g groups, or a 3- to 8-membered heterocycloalkane ring substituted by 0, 1, 2, 3, 4 or 5 R g groups;
R m is independently selected from H, F, Cl, —CH 3 and —CF 3 ;
R g and R j are, independently selected from F, Cl, a C 1 to C 6 alkyl group, —OH, —CN, —NH 2 , —NO 2 , —CO 2 H, a C 1 to C 6 alkoxy group, a mono(C 1 to C 6 alkyl)amino group, a di(C 1 to C 6 alkyl)amino group, —CF 3 , a C 1 to C 6 alkylene group substituted by 0, 1, 2 or 3 R 1 groups, a C 2 to C 6 alkenylene group substituted by 0, 1, 2 or 3 R 1 groups and an oxo group;
R f and R i are independently selected from F, Cl, Br, —OH, —CN, —NO 2 , —CO 2 H, a C 1 to C 6 alkyl group substituted by 0, 1, 2 or 3 R k groups, a C 2 to C 6 alkenyl group substituted by 0, 1, 2 or 3 R k groups, a C 2 to C 6 alkynyl group substituted by 0, 1, 2 or 3 R k groups, a C 3 to C 8 cycloalkyl group substituted by 0, 1, 2 or 3 R k groups, a C 1 to C 6 alkoxy group substituted by 0, 1, 2 or 3 R k groups, a C 3 to C 8 cycloalkyloxy group substituted by 0, 1, 2 or 3 R k groups, —SH, a C 1 to C 6 alkylthio group substituted by 0, 1, 2 or 3 R k groups, a C 3 to C 8 cycloalkylthio group substituted by 0, 1, 2 or 3 R k groups, a (C 1 to C 6 alkyl)carbonyl group substituted by 0, 1, 2 or 3 R k groups, a (C 1 to C 6 alkoxy)carbonyl group substituted by 0, 1, 2 or 3 R k groups, a (C 1 to C 6 alkyl)aminocarbonyl group substituted by 0, 1, 2 or 3 R k groups, a 3- to 8-membered heterocycloalkyl group substituted by 0, 1, 2 or 3 R k groups, a C 1 to C 6 alkylsulfonyl group substituted by 0, 1, 2 or 3 R k groups, —NH 2 , a mono(C 1 to C 6 alkyl)amino group substituted by 0, 1, 2 or 3 R k groups and a di(C 1 to C 6 alkyl)amino group substituted by 0, 1, 2 or 3 R k groups; and
R a , R b , R c , R e , R h , R k and R l are independently selected from F, a C 1 to C 4 alkyl group, —OH, —CN, —NO 2 , —NH 2 , —CO 2 H, a C 1 to C 6 alkoxy group, a mono(C 1 to C 6 alkyl)amino group, a di(C 1 to C 6 alkyl)amino group, —CF 3 and an oxo group.
2. The compound according to claim 1 or pharmaceutically acceptable salt thereof, wherein Y is selected from formula (II-a), formula (II-b), formula (II-c) and formula (II-d):
wherein:
k is 0, 1 or 2;
and n is 1, 2 or 3.
3. The compound according to claim 2 or pharmaceutically acceptable salt thereof, wherein Y is a group represented by formula (II-a):
4. The compound according to claim 2 or pharmaceutically acceptable salt thereof, wherein Y is a group represented by formula (II-d):
and n is 2.
5. The compound according to claim 1 or pharmaceutically acceptable salt thereof, wherein R 3 is H.
6. The compound according to claim 5 or pharmaceutically acceptable salt thereof, wherein R 2 is —CO 2 H or a hydroxycarbonylmethyl group substituted by 0, 1 or 2 R c groups.
7. The compound according to claim 6 or pharmaceutically acceptable salt thereof, wherein R 12 is H.
8. The compound according to claim 1 or pharmaceutically acceptable salt thereof, wherein R 8 and R 9 together form an oxo group or both R 8 and R 9 are H.
9. The compound according to claim 1 or pharmaceutically acceptable salt thereof, wherein R 1 is —CF 3 , —CF 2 H or Cl.
10. The compound according to claim 1 or pharmaceutically acceptable salt thereof, wherein R 5 is a C 6 to C 10 aryl group substituted by 0, 1, 2, 3, 4 or 5 R i groups or a 5- to 10-membered heteroaryl group substituted by 0, 1, 2, 3, or 4 R i groups.
11. The compound according to claim 1 or pharmaceutically acceptable salt thereof, wherein R 4 is a C 1 to C 6 alkyl group substituted by 0, 1, 2 or 3 R e groups, a (C 6 to C 10 aryl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R f groups, a C 3 to C 8 cycloalkyl group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a (C 3 to C 8 cycloalkyl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a C 6 to C 9 spiroalkyl group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a (C 6 to C 9 spiroalkyl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a C 5 to C 9 bicycloalkyl group substituted by 0, 1, 2, 3, 4 or 5 R g groups, a (C 5 to C 9 bicycloalkyl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R g groups or a (C 6 to C 9 heterobicycloalkyl)(C 1 to C 3 alkyl) group substituted by 0, 1, 2, 3, 4 or 5 R g groups.
12. A compound selected from:
(1R,3S)-3-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((4-fluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclopentane-1-carboxylic acid;
(1S,3S)-3-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((4-fluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclopentane-1-carboxylic acid;
1-(trans-4-carbamoylcyclohexyl)-N-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-N-(4-fluorobenzyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide;
4-(4-(((1R,3r,5S)-6,6-dimethyl-3-bicyclo[3.1.0]hexanyl)-(2-oxo-2-(2,4,6-trichlorophenyl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo(2.2.2)octane-1-carboxylic acid;
4-(4-((1-fluorocyclopentyl)methyl-(2-oxo-2-(2,4,6-trichlorophenyl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-((1-fluorocyclopentyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-((1R,3r,5S)-6,6-dimethyl-3-bicyclo[3.1.0]hexanyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo(2.2.2)octane-1-carboxylic acid;
4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-((3,3-dimethylcyclobutyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-(2,2-dimethylbutyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-(2,2-dimethylpropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-(4,4-dimethylcyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-(4,4-dimethylcyclohexyl)carbamoyl)-5-(difluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(2,6-dichloro-4-methylphenyl)-2-oxoethyl)-((1-fluorocyclopentyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(2,6-dichloro-4-methylphenyl)-2-oxoethyl)-((1-methyl-7-oxabicyclo[2.2.1]heptan-4-yl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(2,6-dichloro-4-methylphenyl)-2-oxoethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(2,6-dichloro-4-methylphenyl)-2-oxoethyl)-((3,3-dimethylcyclobutyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(2,6-dichloro-4-methylphenyl)-2-oxoethyl)-(4,4-dimethylcyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(2,6-dichlorophenyl)-2-oxoethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(2,6-dichlorophenyl)-2-oxoethyl)-(2,2-dimethylpropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(2-chloro-6-(trifluoromethyl)phenyl)-2-oxoethyl)-((1R,3r,5S)-6,6-dimethyl-3-bicyclo[3.1.0]hexanyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(2-chloro-6-(trifluoromethyl)phenyl)-2-oxoethyl)-((3,3-dimethylcyclobutyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(2-chloro-6-(trifluoromethyl)phenyl)-2-oxoethyl)-(2,2-dimethylpropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(2-chloro-6-(trifluoromethyl)phenyl)-2-oxoethyl)-(4,4-dimethylcyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(2-chloro-6-methoxyphenyl)-2-oxoethyl)-((1R,3r,5S)-6,6-dimethyl-3-bicyclo[3.1.0]hexanyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(2-chloro-6-methoxyphenyl)-2-oxoethyl)-((3,3-dimethylcyclobutyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(2-chloro-6-methoxyphenyl)-2-oxoethyl)-(4,4-dimethylcyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1-(trifluoromethyl)cyclopropyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1-fluorocyclopentyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1-methylcyclopropyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((2,2,3,3-tetramethylcyclopropyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((4-fluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((4-fluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.1]heptane-1-carboxylic acid;
4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(2,2-dimethylbutyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(2-fluoro-2-methylpropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((2-(3,5-dichloropyridin-4-yl)ethyl)(4-fluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
4-(4-((2-(3-chloro-5-fluoropyridin-4-yl)-2-oxoethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)bicyclo(2.2.2)octane-1-carboxylic acid;
4-(4-((3,3-dimethylcyclobutyl)methyl-(2-oxo-2-(2,4,6-trichlorophenyl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-((4,4-dimethylcyclohexyl)-(2-oxo-2-(2,4,6-trichlorophenyl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-(2,2-dimethylbutyl-(2-oxo-2-(2,4,6-trichlorophenyl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
4-(4-(2,2-dimethylpropyl-(2-oxo-2-(2,4,6-trichlorophenyl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)bicyclo[2.2.2]octane-1-carboxylic acid;
cis-3-(4-(2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-(4,4-dimethylcyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclobutane-1-carboxylic acid;
cis-3-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(4-fluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclobutanecarboxylic acid;
cis-4-(4-(2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-(4,4-dimethylcyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
cis-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((4-fluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-hydroxycyclohexane-1-carboxylic acid;
cis-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((4-fluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-aminocyclohexane-1-carboxylic acid;
cis-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((4-fluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-aminocyclohexane-1-carboxylic acid;
cis-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(4-fluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
cis-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(4-fluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-fluorocyclohexanecarboxylic acid;
N-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-N-((3,5-difluorophenyl)methyl)-1-(trans-4-(hydroxycarbamoyl)cyclohexyl)-5-(trifluoromethyl)pyrazole-4-carboxamide;
N-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-N-((3,5-difluorophenyl)methyl)-1-(trans-4-(methoxycarbamoyl)cyclohexyl)-5-(trifluoromethyl)pyrazole-4-carboxamide;
N-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-N-(3,5-difluorobenzyl)-1-(trans-4-hydroxycyclohexyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide;
N-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-N-(4-fluorobenzyl)-1-(cis-4-(methylsulfonyl)cyclohexyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide;
N-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-N-(4-fluorobenzyl)-1-(trans-4-(methylsulfonyl)cyclohexyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide;
N-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-N-(4-fluorobenzyl)-1-(trans-4-((2-hydroxyethyl)carbamoyl)cyclohexyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide;
trans-1-methyl-4-(4-(2-((2-methylpropan-2-yl)oxy)ethyl-(2-oxo-2-(2,4,6-trichlorophenyl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-1-methyl-4-(4-(2-oxaspiro[3.5]nonan-7-yl-(2-oxo-2-(2,4,6-trichlorophenyl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-3-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-(4,4-dimethylcyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclobutane-1-carboxylic acid;
trans-3-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-(4,4-dimethylcyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclobutane-1-carboxylic acid;
trans-3-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(4-fluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclobutanecarboxylic acid;
trans-4-(2-((1-(4-carboxycyclohexyl)-5-(trifluoromethyl)pyrazole-4-carbonyl)-((3,5-difluorophenyl)methyl)amino)acetyl)-3,5-dichlorobenzoic acid;
trans-4-(4-(((1R,2S)-2-tert-butylcyclopropyl)-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-(((1R,3r,5S)-6,6-dimethyl-3-bicyclo[3.1.0]hexanyl)-(2-oxo-2-(2,4,6-trichlorophenyl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-(((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)(2-hydroxy-2-(2-methoxyphenyl)ethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-(((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)(2-hydroxy-2-(2-methoxyphenyl)ethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-(((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)(2-hydroxy-2-(2-(trifluoromethyl)phenyl)ethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-(((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)(2-hydroxy-2-(2-(trifluoromethyl)phenyl)ethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-(((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)(2-hydroxy-2-(pyridin-2-yl)ethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-(((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)(2-hydroxy-2-(3-methylpyrazin-2-yl)ethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-(((2R)-2-(2,6-dichlorophenyl)-2-fluoroethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-(((2R)-2-(2-chloro-6-methoxyphenyl)-2-hydroxyethyl)-(2,2-dimethylpropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-(((2S)-2-(2,6-dichlorophenyl)-2-fluoroethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-(((2S)-2-(2-chloro-6-methoxyphenyl)-2-hydroxyethyl)-(2,2-dimethylpropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((1-acetylazetidin-3-yl)-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((1-fluorocyclopentyl)methyl-(2-oxo-2-(2,4,6-trichlorophenyl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((1-methyl-4-bicyclo[2.2.1]heptanyl)methyl-(2-oxo-2-(2,4,6-trichlorophenyl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((1-methyl-7-oxabicyclo[2.2.1]heptan-4-yl)methyl-(2-oxo-2-(2,4,6-trichlorophenyl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,4-dichloro-6-methoxyphenyl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,5-dichlorophenyl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-(difluoromethyl)phenyl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-(trifluoromethoxy)phenyl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-(trifluoromethyl)phenyl)-2-oxoethyl)(3,5-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-(trifluoromethyl)phenyl)-2-oxoethyl)-(2-((2-methylpropan-2-yl)oxy)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-(trifluoromethyl)phenyl)-2-oxoethyl)-(2-((2-methylpropan-2-yl)oxy)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-cyanophenyl)-2-oxoethyl)(3,5-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-cyclopropylphenyl)-2-oxoethyl)(3,5-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-((1-fluorocyclopentyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-((1-methyl-4-bicyclo[2.2.1]heptanyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-((1-methyl-7-oxabicyclo[2.2.1]heptan-4-yl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-((1-methyl-4-bicyclo[2.2.1]heptanyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-((1R,3r,5S)-6,6-dimethyl-3-bicyclo[3.1.0]hexanyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-((3,3-dimethylcyclobutyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(difluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-((4,4-dimethylcyclohexyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-(1-methylpiperidin-4-yl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-(1-propan-2-ylpiperidin-4-yl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-(2-((2-methylpropan-2-yl)oxy)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-(2-(3-fluoropiperidin-1-yl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-(2,2-dimethylpropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-(2,2-dimethylbutyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-(3-(2,2-dimethylpropyl)cyclobutyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)(3,5-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)(3,5-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-(4,4-dimethylcyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-(4,4-dimethylpent-2-ynyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-(4,4-dimethylcyclohexyl)carbamoyl)-5-propan-2-ylpyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-(8-propan-2-yl-8-azabicyclo[3.2.1]octan-3-yl)carbamoyl)-5-(trifluoromethyl)pyrazol-1yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-(spiro[2.3]hexan-5-ylmethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-hydroxyphenyl)-2-oxoethyl)(3,5-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-methoxyphenyl)-2-oxoethyl)(3,5-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-methylphenyl)-2-oxoethyl)-((1-fluorocyclopentyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-methylphenyl)-2-oxoethyl)-((1-methyl-7-oxabicyclo[2.2.1]heptan-4-yl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-methylphenyl)-2-oxoethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-methyl-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-methylphenyl)-2-oxoethyl)-((3,3-dimethylcyclobutyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-methylphenyl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-methylphenyl)-2-oxoethyl)-(4,4-dimethylpent-2-ynyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichloro-4-methylphenyl)-2-oxoethyl)-(4,4-dimethylcyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichlorophenyl)-2,2-difluoroethyl)-((4-fluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichlorophenyl)-2-fluoroethyl)(4-fluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(2,6-dichlorophenyl)-2-methylpropyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichlorophenyl)-2-oxoethyl)-((1-fluorocyclopentyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichlorophenyl)-2-oxoethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-methyl-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(2,6-dichlorophenyl)-2-oxoethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(1-fluorocyclopropyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(2,6-dichlorophenyl)-2-oxoethyl)-(2,2-dimethylpropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichlorophenyl)-2-oxoethyl)(3,5-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(2,6-dichlorophenyl)-2-oxoethyl)-(4,4-dimethylcyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichlorophenyl)-2-oxoethyl)-(pyridazin-4-ylmethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2,6-dichlorophenyl)-2-oxoethyl)-(pyrimidin-5-ylmethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-acetamido-6-chlorophenyl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-amino-4-chloropyridin-3-yl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-amino-5-methylphenyl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-amino-6-chlorophenyl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-aminophenyl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-4-(trifluoromethyl)phenyl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-4,6-difluorophenyl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-4,6-dimethylphenyl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-4,6-dimethylphenyl)-2-oxoethyl)-(4,4-dimethylcyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-4-fluorophenyl)-2-oxoethyl)(3,5-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(2-chloro-6-(difluoromethoxy)phenyl)-2-hydroxyethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(2-chloro-6-(difluoromethoxy)phenyl)-2-oxoethyl)-(2,2-dimethylpropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-6-(difluoromethoxy)phenyl)-2-oxoethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(2-chloro-6-(trifluoromethyl)phenyl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-6-(trifluoromethyl)phenyl)-2-oxoethyl)-(4,4-dimethylpent-2-ynyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-6-(trifluoromethyl)phenyl)-2-oxoethyl)-((1R,3r,5S)-6,6-dimethyl-3-bicyclo[3.1.0]hexanyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-6-(trifluoromethyl)phenyl)-2-oxoethyl)-(spiro[2.3]hexan-5-ylmethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-6-(trifluoromethyl)phenyl)-2-oxoethyl)-((3,3-dimethylcyclobutyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-6-(trifluoromethyl)phenyl)-2-oxoethyl)-(4,4-dimethylcyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-6-(trifluoromethyl)phenyl)-2-oxoethyl)-(2,2-dimethylpropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-6-(trifluoromethyl)phenyl)-2-oxoethyl)-((1-fluorocyclopentyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-6-cyano-4-methylphenyl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-6-ethynylphenyl)-2-oxoethyl)(3,5-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(2-chloro-6-fluorophenyl)-2-hydroxyethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(2-chloro-6-fluorophenyl)-2-hydroxyethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(2-chloro-6-fluorophenyl)-2-oxoethyl)-(2,2-dimethylpropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-6-hydroxyphenyl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-6-methoxyphenyl)-2-hydroxyethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(2-chloro-6-methoxyphenyl)-2-hydroxyethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(2-chloro-6-methoxyphenyl)-2-hydroxyethyl)-(4,4-dimethylcyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-6-methoxyphenyl)-2-oxoethyl)-((1R,3r,5S)-6,6-dimethyl-3-bicyclo(3.1.0)hexanyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-6-methoxyphenyl)-2-oxoethyl)-((3,3-dimethylcyclobutyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-6-methoxyphenyl)-2-oxoethyl)-((4,4-dimethylcyclohexyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-6-methoxyphenyl)-2-oxoethyl)-(2,2-dimethylpropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-6-methoxyphenyl)-2-oxoethyl)(3,5-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(2-chloro-6-methoxyphenyl)-2-oxoethyl)-(4,4-dimethylpent-2-ynyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chloro-6-methoxyphenyl)-2-oxoethyl)-(4,4-dimethylcyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chlorophenyl)-2-hydroxyethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(2-chlorophenyl)-2-hydroxyethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(2-chlorophenyl)-2-hydroxypropyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(2-chlorophenyl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(2-chlorothiophen-3-yl)-2-hydroxyethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloro-1,2-thiazol-4-yl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloro-1H-pyrazol-4-yl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloro-1-methylpyrazol-4-yl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichlorophenyl)-2-oxoethyl)(3,5-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2,2-difluoroethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-hydroxyethyl)(4-fluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-methoxyethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(((2R)-5,5-dimethyloxolan-2-yl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(((2R)-5-oxopyrrolidin-2-yl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(((2S)-5,5-dimethyloxolan-2-yl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(((2S)-5-oxopyrrolidin-2-yl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(((R)-tetrahydrofuran-3-yl)methyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(((S)-tetrahydrofuran-3-yl)methyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1-(trifluoromethyl)cyclopropyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1-fluorocyclopentyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1-fluorocyclopentyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1-hydroxycyclopentyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1-methyl-7-oxabicyclo[2.2.1]heptan-4-yl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1-methyl-4-bicyclo[2.2.1]heptanyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1-methyl-4-bicyclo[2.2.1]heptanyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1-methyl-7-oxabicyclo[2.2.1]heptan-4-yl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1-methylcyclohexyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)((1-methylcyclopropyl)methyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1-methylpiperidin-4-yl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1R)-3,3-dimethylcyclopentyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1R,3r,5S)-6,6-dimethyl-3-bicyclo[3.1.0]hexanyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1R,3r,5S)-6,6-dimethyl-3-bicyclo[3.1.0]hexanyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1S)-3,3-dimethylcyclopentyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1S)-3,3-dimethylcyclopentyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1S,2R)-2-phenylcyclopropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1S,2R)-2-propan-2-ylcyclopropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1S,2S)-2-propan-2-ylcyclopropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((2,2,3,3-tetramethylcyclopropyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((2-hydroxyphenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((2R)-3,3-dimethylbutan-2-yl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((2S)-3,3-dimethylbutan-2-yl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((3-((2-methylpropan-2-yl)oxy)cyclobutyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((3-(2,2-dimethylpropyl)cyclobutyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((3,3-dimethylcyclobutyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((3,3-dimethylcyclobutyl)methyl)carbamoyl)-5-methylpyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(difluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-ethylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(hydroxymethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-propan-2-ylpyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-methylpyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(difluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((3-hydroxyphenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((4,4-difluorocyclohexyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)((4,4-dimethylcyclohexyl)methyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((4-fluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-hydroxycyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((4-fluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-cyanocyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((4-fluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-cyanocyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((4-fluorophenyl)methyl)carbamoyl)-5-(2,2,2-trifluoroethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((4-hydroxy-4-methylcyclohexyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((4-hydroxyphenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((6,6-dimethyloxan-3-yl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)((tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(1-((2-methylpropan-2-yl)oxy)propan-2-yl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(1-(2,2-dimethylpropanoyl)azetidin-3-yl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(1-(2-methylpropyl)cyclopropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(1,2,2,6,6-pentamethylpiperidin-4-yl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(1-methoxypropan-2-yl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(1-spiro[2.3]hexan-5-ylethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(2-((2-methylpropan-2-yl)oxy)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(2-((2-methylpropan-2-yl)oxy)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(2,2,2-trifluoroethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(2,2-dimethylbutyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(2,3-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(2,3-dihydro-1H-inden-2-yl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(2,5-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(2-ethyl-2-fluorobutyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(2-fluoro-2-methylpropyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(2-fluoro-2-methylpropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(2-methoxy-2-methylpropyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(3-((2-methylpropan-2-yl)oxy)cyclobutyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(3-((2-methylpropan-2-yl)oxy)cyclobutyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(3,3-dimethylcyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(3,3-dimethylbutyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(3,4-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(3,5-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(3,5-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(3-methylbut-2-enyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(3-methylbut-2-en-1-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(4-(trifluoromethyl)cyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(4-(trifluoromethyl)cyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(4,4-difluorocyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(4,4-dimethylpent-2-ynyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(4,4-dimethylcyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(4,4-dimethylcyclohexyl)carbamoyl)-5-(difluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(4,4-dimethylcyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(4-fluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(4-fluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(4-fluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(4-fluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-fluorocyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(4-fluorobenzyl)carbamoyl)-5-(1,1-difluoroethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(4-methylpentan-2-yl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(5,5-dimethyloxolan-3-yl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(6,6-dimethyloxan-3-yl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(7-oxabicyclo[2.2.1]heptan-4-ylmethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(furan-2-ylmethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(furan-3-ylmethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(isobutyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(isopentyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(neopentyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(oxan-4-yl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(oxolan-3-yl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(piperidin-2-ylmethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(pyrazin-2-ylmethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(pyridin-2-ylmethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(pyridin-3-ylmethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(pyridin-4-ylmethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(spiro[2.3]hexan-5-ylmethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)(spiro[2.5]octan-6-ylmethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-pentan-3-ylcarbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-spiro[2.5]octan-6-ylcarbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3-chloro-5-fluoropyridin-4-yl)-2-hydroxyethyl) ((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(3-chloro-5-fluoropyridin-4-yl)-2-hydroxyethyl) ((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(3-chloro-5-fluoropyridin-4-yl)-2-oxoethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(3-chloro-5-fluoropyridin-4-yl)-2-oxoethyl)-(2,2-dimethylpropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3-chloro-5-fluoropyridin-4-yl)-2-oxoethyl)-(2,2-dimethylbutyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3-chloro-5-fluoropyridin-4-yl)-2-oxoethyl)(3,5-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3-chloro-5-hydroxypyridin-4-yl)-2-oxoethyl)-((4-fluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3-chloro-5-methoxypyridin-4-yl)-2-oxoethyl)-((4-fluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3-chloro-5-methoxypyridin-4-yl)-2-oxoethyl)-(2,2-dimethylpropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3-chloro-5-methylpyridin-4-yl)-2-oxoethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(3-chloro-5-methylpyridin-4-yl)-2-oxoethyl)-(2,2-dimethylpropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3-chloro-5-methylpyridin-4-yl)-2-oxoethyl)(3,5-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-(3-chloropyridin-2-yl)-2-hydroxyethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(3-chloropyridin-2-yl)-2-hydroxyethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(3-chloropyridin-2-yl)-2-hydroxyethyl)-(2,2-dimethylpropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3-chloropyridin-2-yl)-2-hydroxyethyl)-(2,2-dimethylpropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3-chloropyridin-2-yl)-2-oxoethyl) ((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(3-chlorothiophen-2-yl)-2-hydroxyethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(3-chlorothiophen-2-yl)-2-hydroxyethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(4-carbamoyl-2,6-dichlorophenyl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(4-chloro-1H-indazol-3-yl)ethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(4-chloro-1H-indol-3-yl)-2-oxoethyl)-(2,2-dimethylpropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(4-chloro-1H-indol-3-yl)propyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(4-chloro-1H-pyrrolo(2,3-c)pyridin-3-yl)ethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(4-chloro-2,6-dimethylphenyl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(4-chloro-2,6-dimethylphenyl)-2-oxoethyl)-(4,4-dimethylcyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((2-(4-chloro-2-methyl-1H-indol-3-yl)ethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(4-chloro-2-oxo-1H-pyridin-3-yl)-2-oxoethyl)-((4-fluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(4-methylsulfoyl-2,6-dichlorophenyl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(5-chloro-2-methylpyrimidin-4-yl)-2-hydroxyethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(5-chloropyrimidin-4-yl)-2-hydroxyethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-(7-chloro-1H-benzo(d)imidazol-1-yl)ethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-amino-2-(2-chloro-6-fluorophenyl)ethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(4-((2-chloro-1,3-thiazol-4-yl)methyl-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-cyanophenyl)methyl-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-cyclohexyl-2-oxoethyl)(3,5-difluorobenzyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-cyclopentyl-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-cyclopropylethyl)(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((2-oxo-2-(2,4,6-trichlorophenyl)ethyl)-(spiro[2.3]hexan-5-ylmethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((3,3-dimethylcyclobutyl)methyl-(2-oxo-2-(2,4,6-trichlorophenyl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((3,5-difluorobenzyl)(2-(2,4-dimethylfuran-3-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((3,5-difluorobenzyl)(2-(3,5-difluorophenyl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((3,5-difluorobenzyl)(2-(3,5-difluoropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((3,5-difluorobenzyl)(2-(3,5-dimethylisoxazol-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((3,5-difluorobenzyl)(2-(3,5-dimethylpyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((3,5-difluorobenzyl)(2-(4-hydroxyphenyl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((3,5-difluorobenzyl)(2-oxo-2-(2,4,6-trichlorophenyl)ethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((3,5-difluorobenzyl)(2-oxo-2-(pyridin-4-yl)ethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((3,5-difluorophenyl)methyl-(2-(2,4-dimethyl-6-oxo-1H-pyridin-3-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((3,5-difluorophenyl)methyl-(2-(2,4-dimethylpyridin-3-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((3,5-difluorophenyl)methyl-(2-(2,4-dimethylthiophen-3-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((3,5-difluorophenyl)methyl-(2-(2,6-dihydroxyphenyl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((3,5-difluorophenyl)methyl-(2-(2,6-dimethoxyphenyl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((3,5-difluorophenyl)methyl-(2-(2-hydroxy-6-methoxyphenyl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((3,5-difluorophenyl)methyl-(2-(3,5-dimethoxypyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((3,5-difluorophenyl)methyl-(2-(4,6-dimethylpyrimidin-5-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((3,5-difluorophenyl)methyl-(2-oxo-2-(1H-pyrazol-3-yl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((3,5-difluorophenyl)methyl-(2-oxo-2-(2,4,6-trihydroxypyrimidin-5-yl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((3-cyano-3-methylcyclopentyl)-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((3-cyanophenyl)methyl-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((3-tert-butylcyclobutyl)-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((3-tert-butylcyclobutyl)-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((3-tert-butylcyclobutyl)methyl-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((3-tert-butylcyclobutyl)methyl-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((4,4-dimethylcyclohexyl)-(2-(3,5-dimethyl-1H-pyrazol-4-yl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((4,4-dimethylcyclohexyl)-(2-oxo-2-(2,4,6-trichlorophenyl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((4,4-dimethylcyclohexyl)-(2-oxo-2-(2,4,6-trichlorophenyl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((4,4-dimethylcyclohexyl)methyl-(2-oxo-2-(2,4,6-trichlorophenyl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-((4-chloro-1,3-thiazol-2-yl)methyl-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((4-chlorobenzyl)(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((4-cyanophenyl)methyl-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((5-chloro-1,3-thiazol-2-yl)methyl-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((cyclobutylmethyl)(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((cyclohexylmethyl)(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((cyclopentylmethyl)(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-((cyclopropylmethyl)(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-(1-adamantylmethyl-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-(1-cyclopentylethyl-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-(2-(2,6-dichloro-4-fluorophenyl)ethyl-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-(2-(2,6-dichlorophenyl)propyl-((3,5-difluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-(2-(2,6-dichlorophenyl)propyl-((4-fluorophenyl)methyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-(2-(3,5-dichloropyridin-4-yl)ethyl-((4-fluorophenyl)methyl)carbamoyl)-3,5-bis(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-(2-(4-chloro-1H-indol-3-yl)ethyl-(2,2-dimethylpropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-(2-(4-chloro-1H-indol-3-yl)ethyl-(4,4-dimethylcyclohexyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-(2-(4-chloro-2-methyl-1H-indol-3-yl)ethyl-(2,2-dimethylpropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-(2,2-dimethylbutyl-(2-oxo-2-(2,4,6-trichlorophenyl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-(2,2-dimethylpropyl-(2-(1H-indol-3-yl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-(2,2-dimethylpropyl-(2-oxo-2-(2,4,6-trichlorophenyl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-(2-tert-butylsulfanylethyl-(2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-(2-tert-butylsulfinylethyl-(2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-(2-tert-butylsulfonylethyl-(2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-(3-bicyclo[2.2.1]heptanyl-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-(4,4-dimethylpent-2-ynyl-(2-oxo-2-(2,4,6-trichlorophenyl)ethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-(8-azabicyclo[3.2.1]octan-3-yl-(2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(4-(benzyl(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)cyclohexanecarboxylic acid;
trans-4-(4-(cyclohexyl-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-(cyclopentyl-(2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(5-(aminomethyl)-4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(5-chloro-4-((2-(2,6-dichloro-4-fluorophenyl)-2-oxoethyl)-(4,4-dimethylcyclohexyl)carbamoyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(5-chloro-4-((2-(2,6-dichloro-4-methylphenyl)-2-oxoethyl)-(2,2-dimethylpropyl)carbamoyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(5-chloro-4-((2-(2,6-dichloro-4-methylphenyl)-2-oxoethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(5-chloro-4-((2-(2,6-dichlorophenyl)-2-oxoethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(5-chloro-4-((2-(2,6-dichlorophenyl)-2-oxoethyl)-(2,2-dimethylpropyl)carbamoyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(5-chloro-4-((2-(2,6-dichlorophenyl)-2-oxoethyl)-(4,4-dimethylcyclohexyl)carbamoyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(5-chloro-4-((2-(2-chloro-6-methoxyphenyl)-2-hydroxyethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(5-chloro-4-((2-(2-chloro-6-methoxyphenyl)-2-hydroxyethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(5-chloro-4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(5-chloro-4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1-methylcyclopropyl)methyl)carbamoyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(5-chloro-4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((3,3-dimethylcyclobutyl)methyl)carbamoyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(5-chloro-4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1-methyl-7-oxabicyclo[2.2.1]heptan-4-yl)methyl)carbamoyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(5-chloro-4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((1-(trifluoromethyl)cyclopropyl)methyl)carbamoyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(5-chloro-4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(5-chloro-4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(2-ethyl-2-fluorobutyl)carbamoyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(5-cyano-4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(2,2-dimethylpropyl)carbamoyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid;
trans-4-(5-cyclopropyl-4-((2-(2,6-dichlorophenyl)-2-oxoethyl)((1R,3r,5S)-6,6-dimethylbicyclo[3.1.0]hexan-3-yl)carbamoyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid;
trans-4-(5-cyclopropyl-4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(5-tert-butyl-4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-((3,5-difluorophenyl)methyl)carbamoyl)pyrazol-1-yl)cyclohexane-1-carboxylic acid;
trans-4-(4-((2-(3,5-dichloropyridin-4-yl)-2-oxoethyl)-(2,2-dimethylpropyl)carbamoyl)-5-(trifluoromethyl)pyrazol-1-yl)-1-methylcyclohexane-1-carboxylic acid; and
trans-4-(4-((2-(3,5-dichloro-4-pyridinyl)-2-oxoethyl)(3,3,3-trifluoro-2,2-dimethylpropyl)carbamoyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)-1-methylcyclohexanecarboxylic acid.
13. The method of treating a disease using a compound according to claim 1 or pharmaceutically acceptable salt thereof, wherein the disease is multiple sclerosis, chronic rheumatoid arthritis, ankylosing spondylitis, systemic erythematodes, psoriasis, psoriatic arthritis, inflammatory bowel disease or asthma.
14. A pharmaceutical composition comprising a compound according to claim 1 or pharmaceutically acceptable salt thereof.