EP2 AND EP4 AGONISTS AS AGENTS FOR THE TREATMENT OF INFLUENZA A VIRAL INFECTION
The present invention is directed to the use of EP2 and/or EP4 agonists as therapeutics for the treatment of diseases associated with influenza A viruses, such as for example H5N1 and mutations thereof.
1 - 20 . (canceled)
21 : A method of inhibiting the release of overstimulated cytokines and/or chemokines in a subject, said method comprising administering to a subject in need thereof an amount of beraprost effective to inhibit the release of overstimulated cytokines and/or chemokines.
22 : The method of claim 21 , wherein said cytokines and/or chemokines are inflammatory cytokines or chemokines.
23 : The method of claim 21 , wherein the overstimulated cytokines comprise TNFα.
24 : The method of claim 21 , wherein the overstimulated cytokines comprise IFN-gamma.
25 : The method of claim 21 , wherein said beraprost is a pharmaceutically acceptable salt or cyclodextrin clathrate.