THREE-DIMENSIONAL TISSUE MAPPING SYSTEM
A three-dimensional biopsy mapping and focal therapy system, method, and apparatus uses an imaging system to generate and store a three-dimensional image of a target tissue based on an ultrasound image of the target tissue by storing a user generated contour of the target tissue and surrounding anatomical structures, calculating the volume of the target tissue and surrounding anatomical structures. Biopsy site location and orientation are generated and stored with the three-dimensional image. Biopsied tissue specimens are examined for lesions, and the lesion sites are recorded in the three-dimensional image. Based on the pathology information and biopsy sites, the volume of the overall tumor is calculated and represented in the three-dimensional image. The three-dimensional image of the target tissue and lesion tissue is manipulable, and the image is used to provide localized therapy to the diseased tissue.
1 . A method of generating a biopsy needle site plan upon a three-dimensional image of a target tissue from an animal, the method comprising:
receiving an image signal of a target tissue of an animal comprising a plurality of two dimensional image slices of the target tissue;
forming a three dimensional image of the target tissue from the plurality of two dimensional image slices;
receiving input information designating at least one biopsy needle site on one of the plurality of two dimensional images;
calculating at least one biopsy needle path through the three-dimensional image of the target tissue based on the biopsy needle site input information; and
performing an image process rendering a three-dimensional image of the target tissue and the at least one biopsy needle path through the three-dimensional image of the target tissue.
2 . The method of claim 1 , wherein the image signal is generated by an imaging device configured to emit and acquire a signal of the target tissue where the target tissue is located within an animal.
3 . The method of claim 2 , wherein the imaging device is an ultrasound data acquirer, and the image signal is ultrasound data output by the ultrasound data acquirer.
4 . The method of claim 3 , further comprising:
receiving a biopsy template grid image corresponding to biopsy needle apertures of a biopsy needle template, wherein the biopsy needle template is at the exterior of the animal;
wherein the ultrasound data acquirer is an ultrasound probe, and the ultrasound data includes transverse and sagittal images of the target tissue; and
wherein the biopsy needle template is operably connected to the ultrasound probe whereby the biopsy template grid image is superimposed upon the ultrasound data output.
5 . The method of claim 4 , further comprising:
forming a two-dimensional biopsy site plan grid image, corresponding to the biopsy needle apertures, wherein the biopsy site plan grid image is superimposed on the ultrasound data output, and wherein the biopsy site plan grid is configured to receive input from a user; and
recording the input information designating at least one biopsy needle site with the biopsy site plan grid image by a user.
6 . The method of claim 1 , further comprising:
forming target tissue volume data based on the three-dimensional image of the target tissue; and
calculating a length of a biopsy tissue specimen removed by a biopsy of the target tissue at the biopsy needle site.
7 . The method of claim 6 , further comprising:
receiving input information designating a core bed length of a biopsy needle; and
calculating a count of core bed lengths required to remove the length of the biopsy tissue specimen at the biopsy needle site.
8 . The method of claim 6 , further comprising:
receiving input information designating a biopsy tissue specimen length of the target tissue to remove from the biopsy needle site; and
calculating a core bed length of a biopsy needle required to remove the biopsy tissue specimen length of the target tissue from the biopsy needle site.
9 . The method of claim 8 , wherein the core bed forms projections for marking the biopsy tissue specimen.
10 . A non-transitory computer readable medium comprising computer executable instructions, execution of which causes a processor to perform the following acts:
acquiring image data of a target tissue in an animal comprising a plurality of two-dimensional image slices of the target tissue;
forming a three-dimensional image of the target tissue from a plurality of two dimensional images;
receiving input information designating at least one biopsy needle site on one of the plurality of two dimensional images;
calculating at least one biopsy needle path through the three-dimensional image of the target tissue based on the biopsy needle site input information; and
performing an image process forming a three-dimensional image of the target tissue and the at least one biopsy needle path through the three-dimensional image of the target tissue.
11 . The method of claim 10 , wherein the image signal is generated by an imaging device configured to emit and acquire a signal of the target tissue where the target tissue is located within an animal.
12 . The method of claim 11 , wherein the imaging device is an ultrasound data acquirer, and the image signal is ultrasound data output by the ultrasound data acquirer.
13 . The method of claim 12 , further comprising:
receiving a biopsy template grid image corresponding to biopsy needle apertures of a biopsy needle template, wherein the biopsy needle template is at the exterior of the animal;
wherein the ultrasound data acquirer is an ultrasound probe, and the ultrasound data includes transverse and sagittal images of the target tissue; and
wherein the biopsy needle template is operably connected to the ultrasound probe whereby the biopsy template grid image is superimposed upon the ultrasound data output.
14 . The method of claim 13 , further comprising:
forming a two-dimensional biopsy site plan grid image, corresponding to the biopsy needle apertures, wherein the biopsy site plan grid image is superimposed on the ultrasound data output, and wherein the biopsy site plan grid is configured to receive input from a user; and
recording the input information designating at least one biopsy needle site with the biopsy site plan grid image by a user.
15 . The method of claim 10 , further comprising:
forming target tissue volume data based on the three-dimensional image of the target tissue; and
calculating a length of a biopsy tissue specimen removed by a biopsy of the target tissue at the biopsy needle site.
16 . The method of claim 15 , further comprising:
receiving input information designating a core bed length of a biopsy needle; and
calculating a count of core bed lengths required to remove the length of the biopsy tissue specimen at the biopsy needle site.
17 . The method of claim 15 , further comprising:
receiving input information designating a biopsy tissue specimen length of the target tissue to remove from the biopsy needle site; and
calculating a core bed length of a biopsy needle required to remove the biopsy tissue specimen length of the target tissue from the biopsy needle site.
18 . The method of claim 17 , wherein the core bed forms projections for marking the biopsy tissue specimen.
19 . A method of generating a biopsy needle site plan on a three-dimensional image of a target tissue residing in an animal, the method comprising:
receiving ultrasound images of a target tissue of an animal comprising a plurality of two-dimensional image slices of the target tissue, wherein the ultrasound images are generated by an ultrasound probe;
contouring the margins of the target tissue on the two-dimensional image slices,
forming a three-dimensional image of the target tissue from the margin contours of the plurality of two-dimensional image slices;
forming target tissue volume data based on the margin contours;
receiving a biopsy template grid image corresponding to biopsy needle apertures of a biopsy needle template, the grid images superimposed upon the ultrasound images, wherein the biopsy needle template is at the exterior of the animal and operably connected to the ultrasound probe;
forming a two-dimensional biopsy site plan grid image corresponding to the biopsy needle apertures, wherein the biopsy site plan grid image is superimposed on the ultrasound images, and wherein the biopsy site plan grid is configured to receive input information from a user designating at least one biopsy needle site on one of the plurality of two-dimensional image slices and the user inputs information by an input device;
calculating at least one biopsy needle path through the three-dimensional image of the target tissue based on the biopsy needle site input information;
performing an image process rendering a three-dimensional image of the target tissue and the at least one biopsy needle path through the three-dimensional image of the target tissue formed from the margin contours, wherein the needle path extends from the three-dimensional image; and
calculating a length of a biopsy tissue specimen removed by a biopsy of the target tissue at the biopsy needle site.
20 . The method of claim 19 , further comprising:
receiving input information by a user input device designating a core bed length of a biopsy needle; and
calculating a count of core bed lengths required to remove the length of the biopsy tissue specimen at the biopsy needle site.
21 . The method of claim 20 , further comprising:
receiving input information by a user input device designating a biopsy tissue specimen length of the target tissue to remove from the biopsy needle site; and
calculating a core bed length of a biopsy needle required to remove the biopsy tissue specimen length of the target tissue from the biopsy needle site.
22 . The method of claim 19 , wherein the three-dimensional image of the target tissue and the at least one biopsy needle path through the three-dimensional image of the target tissue may be rotated in three dimensions about a central axis by a user by a user input device to view the target tissue and needle path from different viewing angles.