IP Library › Granted Patent US 9,463,173
Granted Patent B2
US 9,463,173 · App. 14/637,784 · Granted Oct 11, 2016

Compositions and methods for treating obesity and obesity-related conditions

Inventors: Namandje Bumpus (Washington, DC); Lindsay Avery (S. Hamilton, MA)
Assignee: THE JOHNS HOPKINS UNIVERSITY
A61K31/19
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Quick Facts
Patent No.
US 9,463,173
App. No.
14/637,784
Granted
Oct 11, 2016
Kind
B2
Abstract

The present invention relates to the field of obesity. More specifically, the present invention provides methods and compositions useful in treating obesity and obesity-associated conditions. In one embodiment, a method for treating obesity in a subject comprises the step of administering an effective amount of valproic acid (VPA) or an analog, derivative or metabolite thereof to the subject.

Claims (6)

1. A method for reducing hepatic fat accumulation and serum glucose in a subject comprising the step of administering an effective amount of valproic acid (VPA) or metabolite thereof to the subject, wherein the VPA metabolite is one or more of 2-ene-VPA, 4-ene-VPA, 3-OH-VPA, and 3-keto-VPA.

2. The method of claim 1 , wherein the VPA metabolite is 4-ene VPA.

3. A method for treating obesity in a subject comprising the step of administering an effective amount of valproic acid (VPA) or metabolite thereof to the subject wherein the VPA metabolite is one or more of 2-ene-VPA, 4-ene-VPA, 3-OH-VPA, and 3-keto-VPA.

4. The method of claim 3 , wherein the VPA metabolite is 4-ene VPA.

5. A method for treating type 2 diabetes in a subject comprising the step of administering an effective amount of valproic acid (VPA) or metabolite thereof to the subject, wherein the VPA metabolite is one or more of 2-ene-VPA, 4-ene-VPA, 3-OH-VPA, and 3-keto-VPA.

6. The method of claim 5 , wherein the VPA metabolite is 4-ene VPA.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jul 5, 2016
From: JOHNS HOPKINS UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 039251/0824 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 16, 2016
From: BUMPUS, NAMANDJE; AVERY, LINDSAY
To: THE JOHNS HOPKINS UNIVERSITY
Reel/Frame 038603/0116 →
Continuity (2)
Provisional Application 61947537 · Mar 4, 2014
Related Publication 20150250747A1 · Sep 10, 2015