IP Library › Granted Patent US 9,353,094
Granted Patent B2
US 9,353,094 · App. 14/639,501 · Granted May 31, 2016

Substituted quinoxalines as kinase inhibitors

Inventors: Amarnath Natarajan (Elkhorn, NE); Qianyi Chen (Shanghai, CN); Vashti C. Bryant (Cary, NC); Rajkumar Rajule (Omaha, NE)
Assignees: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA; THE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
C07D409/14C07D241/42C07D241/44C07D401/12C07D401/14C07D403/12C07D405/04C07D405/14C07D471/04
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Quick Facts
Patent No.
US 9,353,094
App. No.
14/639,501
Granted
May 31, 2016
Kind
B2
Abstract

Disclosed herein are compounds of formula (I) and methods of inhibiting IKKβ and the NF-κB signaling and mTOR pathways.

Claims (18)

1. A compound having a structure selected from:

or a salt thereof.

2. The compound of claim 1 , having a structure

or a salt thereof.

3. The compound of claim 1 , having a structure

or a salt thereof.

4. The compound of claim 1 , having a structure

or a salt thereof.

5. The compound of claim 1 , having a structure

or a salt thereof.

6. The compound of claim 1 , having a structure

or a salt thereof.

7. The compound of claim 1 , having a structure

or a salt thereof.

8. A method of decreasing the inhibitor of kappa B kinase β activity in a cell, comprising contacting the cell with an effective amount of the compound of claim 1 .

9. The method of claim 8 , wherein the inhibitor of kappa B kinase β is hyperphosphorylated.

10. A method of inhibiting the nuclear factor kappaB signaling pathway in a cell, comprising contacting the cell with an effective amount of the compound of claim 1 .

11. A method of inhibiting the mammalian target of rapamycin signaling pathway in a cell, comprising contacting the cell with an effective amount of the compound of claim 1 .

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 9, 2016
From: NATARAJAN, AMARNATH
To: THE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
Reel/Frame 038517/0130 →
CONFIRMATORY LICENSE Recorded Mar 19, 2015
From: UNIVERSITY OF NEBRASKA MEDICAL CENTER
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 035223/0895 →
Continuity (4)
Continuation 13883026
Provisional Application 61415934 · Nov 22, 2010
Provisional Application 61416001 · Nov 22, 2010
Related Publication 20150274709A1 · Oct 1, 2015