IP Library › Granted Patent US 10,494,402
Granted Patent B2
US 10,494,402 · App. 14/646,298 · Granted Dec 3, 2019

Peptides that stimulate subcutaneous adipogenesis

Inventors: Eva A. Turley (London, CA); Seyed Bahram Bahrami (Emeryville, CA); Mina J. Bissell (Berkeley, CA)
Assignee: The Regents of the University of California
C07K7/08A61K8/64A61K31/167A61K38/03A61K38/08A61Q19/001A61Q19/08C07K7/06C07K14/70596A61K38/00
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Quick Facts
Patent No.
US 10,494,402
App. No.
14/646,298
Granted
Dec 3, 2019
Kind
B2
Abstract

Peptides of 5 to 14 amino acids in length that stimulate subcutaneous adipogenesis in mammals and uses thereof are provided.

Claims (15)

1. A pharmaceutical or cosmetic composition comprising a pharmaceutically or cosmetically acceptable carrier and a peptide, wherein the peptide has a length of 6 to 14 amino acids and comprises the sequence ASEVSA (SEQ ID NO: 94), wherein the composition additionally comprises, in the same or a different peptide, one or more of an amino acid sequence selected from the group consisting of: KSEVSK (SEQ ID NO: 3), KQEVSK (SEQ ID NO: 4), KQEVDK (SEQ ID NO: 5), KQENTK (SEQ ID NO: 6), KSEVLK (SEQ ID NO: 7), KQDVSK (SEQ ID NO: 8), KQELDR (SEQ ID NO: 9), KSEISK (SEQ ID NO: 12), KNEVSK (SEQ ID NO: 13), KSEVTK (SEQ ID NO: 14), KSEVNK (SEQ ID NO: 15), KSDVSK (SEQ ID NO: 16), KSQVSK (SEQ ID NO: 17), KPEVSK (SEQ ID NO: 18), KSEVGK (SEQ ID NO: 19), KCEVSK (SEQ ID NO: 24), KSKPSK (SEQ ID NO: 25), KKEVSK (SEQ ID NO: 26), KSETSK (SEQ ID NO: 28), KSNVSK (SEQ ID NO: 29), KDEVSK (SEQ ID NO: 30), KSAVSK (SEQ ID NO: 32), KWENSK (SEQ ID NO: 33), KMEVSK (SEQ ID NO: 34), KSEVQK (SEQ ID NO: 35), KSEVHK (SEQ ID NO: 36), ASEVSK (SEQ ID NO: 38), KAEVSK (SEQ ID NO: 39), KSEVAK (SEQ ID NO: 40), KSEVSA (SEQ ID NO: 41), and KAEVAK (SEQ ID NO: 95).

2. The composition of claim 1 , wherein the length of at least one peptide is 6 to 8 amino acids.

3. The composition of claim 1 , wherein said one or more of an amino acid sequence is KSEVSK (SEQ ID NO: 3).

4. The composition of claim 1 , wherein the composition is for topical, subcutaneous, or transdermal administration.

5. The composition of claim 1 , wherein the composition is for injection.

6. The composition of claim 1 , wherein the composition further comprises collagen.

7. The composition of claim 6 , wherein the collagen is a bovine collagen, a porcine collagen, or a human collagen.

8. The composition of claim 6 , wherein the collagen is a synthetic collagen.

9. The composition of claim 1 , wherein the composition further comprises an anesthetic.

10. The composition of claim 9 , wherein the anesthetic comprises lidocaine.

11. The composition of claim 1 , wherein the composition is a skin cream.

12. A peptide having a length of 6 to 8 amino acids comprising the sequence ASEVSA (SEP ID NO: 94), wherein the peptide bears one or more protecting groups.

13. The composition of claim 12 , wherein the protecting group comprises an acetyl group at the amino-terminus of the peptide.

14. The peptide of claim 12 , wherein the amino acid sequence of the peptide comprises ASEVSA (SEQ ID NO: 94) in combination with one or more of: KSEVSK (SEQ ID NO: 3), KQEVSK (SEQ ID NO: 4), KQEVDK (SEQ ID NO: 5), KQENTK (SEQ ID NO: 6), KSEVLK (SEQ ID NO: 7), KQDVSK (SEQ ID NO: 8), KQELDR (SEQ ID NO: 9), KSEISK (SEQ ID NO: 12), KNEVSK (SEQ ID NO: 13), KSEVTK (SEQ ID NO: 14), KSEVNK (SEQ ID NO: 15), KSDVSK (SEQ ID NO: 16), KSQVSK (SEQ ID NO: 17), KPEVSK (SEQ ID NO: 18), KSEVGK (SEQ ID NO: 19), KSDSSK (SEQ ID NO: 20), KSEASK (SEQ ID NO: 22), KCEVSK (SEQ ID NO: 24), KSKPSK (SEQ ID NO: 25), KKEVSK (SEQ ID NO: 26), KSETSK (SEQ ID NO: 28), KSNVSK (SEQ ID NO: 29), KSEVSK (SEQ ID NO: 30), KSAVSK (SEQ ID NO: 32), KWEVSK (SEQ ID NO: 33), KMEVSK (SEQ ID NO: 34), KSEVQK (SEQ ID NO: 35), KSEVHK (SEQ ID NO: 36), ASEVSK (SEQ ID NO: 38), KAEVSK (SEQ ID NO: 39), KSEVAK (SEQ ID NO: 40), KSEVSA (SEQ ID NO: 41), KAEVAK (SEQ ID NO: 95), and KSAASK (SEQ ID NO: 96).

15. The peptide of claim 14 , wherein the amino acid sequence of the peptide comprises a combination of KSEVSK (SEQ ID NO: 3) and ASEVSA (SEQ ID NO: 94).

Assignments (2)
CONFIRMATORY LICENSE Recorded Oct 15, 2019
From: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
To: UNITED STATES DEPARTMENT OF ENERGY
Reel/Frame 050720/0804 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 17, 2017
From: TURLEY, EVA A.; BAHRAMI, SEYED BAHRAM; BISSELL, MINA J.
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 044159/0567 →
Continuity (3)
Provisional Application 61729626 · Nov 25, 2012
Provisional Application 61778084 · Mar 12, 2013
Related Publication 20150284433A1 · Oct 8, 2015