Absorbant and reflecting biocompatible dyes for highly accurate medical implants
A light-polymerizable composition for additive manufacturing of resorbable scaffolds and implants comprising a biocompatible resin. The biocompatible resin includes a combination of photo-initiators or a dye-initiator package tailored to manufacture implants with the desired physical and chemical properties. A dye or other constituent controls between layer (z) resolution of the manufactured part built in an additive manufacturing device. A light absorber or other constituent controls within layer (x-y) resolution of the manufactured part.
1. A method for use in tissue engineering applications comprising:
furnishing a light-polymerizable composition including at least one polymer, at least one solvent, and a photo-initiator package comprising a first photo-initiator and a second photo-initiator;
exposing the light-polymerizable composition to a first light source of a first wavelength in an additive manufacturing device to partially cure the composition by activating the first photo-initiator while the second photo-initiator limits depth penetration of light of the first wavelength that activates the first photo-initiator in the additive manufacturing device; and
thereafter exposing the light-polymerizable composition to a second light source of a second wavelength different from the first wavelength to further cure the composition by activating the second photo-initiator to produce free radicals at a higher rate when exposed to the second light source of the second wavelength than when exposed to the first light source of the first wavelength,
wherein furnishing the light-polymerizable composition includes furnishing a light-polymerizable composition including a photo-initiator package in which the second photo-initiator is Bis(.eta.5-2,4-cylcopentadien-1-yl)-bis(2,6-difluoro-3-(1H-pyrrol-1-yl)-phenyl) titanium.
2. The method of claim 1 , wherein furnishing the light-polymerizable composition includes furnishing a light-polymerizable composition including a photo-initiator package in which one or both of the first and second photo-initiators are an acylphosphine oxide.
3. The method of claim 2 , wherein furnishing the light-polymerizable composition includes furnishing a light-polymerizable composition including a photo-initiator package in which the first photo-initiator is Bis(2,4,6-trimethylbenzoyl)-phenylphosphineoxide (BAPO).
4. The method of claim 2 , wherein furnishing the light-polymerizable composition includes furnishing a light-polymerizable composition including a photo-initiator package in which the amount of the first photo-initiator and the second photo-initiator are about 0.1 to 5.0% by weight of the at least one polymer and the at least one solvent.
5. The method of claim 1 , wherein furnishing the light-polymerizable composition includes furnishing a light-polymerizable composition including a photo-initiator package in which the amount of Bis(.eta.5-2,4-cylcopentadien-1-yl)-bis(2,6-difluoro-3-(1H-pyrrol-1-yl)-phenyl) titanium by weight of the at least one polymer and the at least one solvent is about 0.1 to 5.0%.
6. The method of claim 4 , wherein furnishing the light-polymerizable composition includes furnishing a light-polymerizable composition including a photo-initiator package in which the amount of BAPO by weight of the at least one polymer and the at least one solvent is about 0.1 to 5.0%.
7. The method of claim 1 , wherein furnishing the light-polymerizable composition includes furnishing a light-polymerizable composition including a photo-initiator package in which the first photo-initiator is Bis(2,4,6-trimethylbenzoyl)-phenylphosphineoxide (BAPO) and the second photo-initiator is Bis(.eta.5-2,4-cylcopentadien-I-yl)-bis(2,6-difluoro-3-(IH-pyrrol-I-yl)-phenyl) titanium.