Zinc amino acid complex with cysteine
Provided are compositions, e.g., oral and personal care products, comprising (i) a tetrabasic zinc-amino acid or trialkyl glycine-halide complex, and (ii) cysteine in free or in orally or cosmetically acceptable salt form, together with methods of making and using the same.
1. A composition comprising (i) a tetrabasic zinc-amino acid halide complex and (ii) cysteine in free or in orally or cosmetically acceptable salt form; wherein the amino acid is lysine, and wherein the composition comprises an amount of cysteine effective to provide a precipitate after a four-fold or higher dilution with water.
2. The composition according to claim 1 , wherein the tetrabasic zinc-amino acid complex is formed from precursors, wherein the precursors are tetrabasic zinc chloride, an amino acid source, and a chloride source, wherein part of the chloride source can be the amino acid source, or hydrochloric acid.
3. The composition according to claim 1 , wherein the tetrabasic zinc halide is tetrabasic zinc chloride.
4. The composition according to claim 1 , wherein the tetrabasic zinc halide amino acid complex is made by combining tetrabasic zinc chloride with an amino acid hydrochloride or a free basic amino acid.
5. The composition according to claim 1 , which upon dilution with water, provides a precipitate comprising an insoluble zinc-containing complex.
6. The composition according to claim 1 , which instantly forms a precipitate upon a four-fold or higher dilution with water.
7. The composition according to claim 1 , comprising an amount of cysteine effective to provide delayed precipitation after a four-fold or higher dilution with water.
8. The composition according to claim 1 , capable of forming a precipitate upon a four-fold or higher dilution with water, wherein the precipitate is resistant to acid at least at a pH of 5.5.
9. The composition according to claim 1 , wherein the total amount of zinc present in the composition is 0.2 to 8% by weight of the composition.
10. The composition according to claim 1 , having a pH of 8.4 to 8.8 before dilution.
11. The composition of claim 1 , wherein the amount of cysteine is 0.05 to 0.5% by weight.
12. The composition of claim 1 , wherein the cysteine is a cysteine hydrohalide.
13. The composition according to claim 1 , which is an antiperspirant or deodorant product, further comprising a cosmetically acceptable carrier.
14. The composition of claim 1 which is a personal care product selected from liquid hand soap, body wash, dermal lotions, dermal creams, and dermal conditioners further comprising a cosmetically acceptable carrier.
15. The composition of claim 1 which is an oral care product, further comprising an orally acceptable carrier.
16. A method of killing bacteria, reducing perspiration, and/or reducing body odor comprising applying to skin an effective amount of the composition of claim 14 .
17. A method of killing bacteria, treating or reducing the incidence of acne or topical skin infections, or to provide a visual signal when washing comprising washing the skin with water and an effective amount of the composition of claim 14 .
18. A method to reduce and inhibit acid erosion of the enamel, clean the teeth, reduce bacterially-generated biofilm and plaque, reduce gingivitis, inhibit tooth decay and formation of cavities, and/or reduce dentinal hypersensitivity comprising applying an effective amount of a composition according to claim 15 to the oral cavity of a person in need thereof.