Formulations and carrier systems including compound interactive domains
A method of creating a formulation for a compound includes determining a compound interactive agent comprising at least one group that interacts with the compound, creating a carrier agent by conjugating at least one compound interactive domain comprising the at least one group that interacts with the compound with at least one hydrophilic domain, and combining the compound and the carrier agent to create the formulation. Creating the carrier agent may further include conjugating the at least one compound interactive domain with at least one hydrophobic domain so that the at least one compound interactive domain is positioned between the at least one hydrophilic domain and the at least one hydrophobic domain.
1. A method of creating a formulation for a compound, comprising:
creating a carrier agent by conjugating at least one compound interactive domain comprising at least one fluorenylmethyloxycarbonyl group or a derivative thereof with at least one hydrophilic domain and with at least one hydrophobic domain so that the at least one compound interactive domain is positioned between the at least one hydrophilic domain and the at least one hydrophobic domain, the compound interactive domain being different from the at least one hydrophilic domain and from the at least one hydrophobic domain, and
combining the compound and the carrier agent to create the formulation.
2. The method of claim 1 wherein the at least one hydrophobic domain comprises a lipid.
3. The method of claim 1 wherein the at least one hydrophilic domain comprises at least one hydrophilic oligomer or at least one hydrophilic polymer.
4. The method of claim 3 wherein the hydrophilic oligomer or the hydrophilic polymer is a polyalkylene oxide, a polyvinylalcohol, a polyacrylic acid, a polyacrylamide, a polyoxazoline, or a polypeptide.
5. The method of claim 1 wherein the at least one hydrophilic domain comprises at least one ionic group, at least one carboxylic acid group, at least one amine group, at least one saccharide group, or at least one polysaccharide group.
6. The method of claim 1 wherein the formulation forms a complex selected from a group consisting of a micelle, an emulsion, a cream, a liposome, a spherulite, a solid-lipid nanoparticle, a hydrogel or a cubic phase lipogel.
7. The method of claim 1 wherein the at least one hydrophobic domain comprises at least one lipid, at least one tocopherol, at least one hydrophobic oligomer or at least one hydrophobic polymer.
8. The method of claim 1 wherein the at least one hydrophobic domain comprises at least one of a polymethylacryl, a polyethylene, a polystyrene, a polyisobutane, a polyester, a polypeptide, or a derivative thereof.
9. The method of claim 1 wherein the at least one hydrophobic domain comprises a farnesylthiosalicylate group.
10. The method of claim 1 wherein the compound is JP4-039, paclitaxel, FK506, cyclosporin A, a protoporphyrin, GW4064, rose bengal, epigallocatechin gallate, curcumin, indomethacin, tamoxifen or doxorubicin.
11. The method of claim 1 wherein the compound is paclitaxel and the hydrophilic domain comprises polyethylene glycol.
12. The method of claim 1 wherein the at least one compound interactive domain of the carrier is covalently bonded to the at least one hydrophilic domain.
13. The method of claim 1 wherein the at least one compound interactive domain of carrier agent is covalently bonded to the at least one hydrophilic domain and is covalently bonded to the at least one hydrophobic domain.
14. A formulation to deliver a compound to a patient, comprising:
the compound and a carrier agent comprising at least one hydrophilic domain conjugated with at least one compound interactive domain comprising at least one fluorenylmethyloxycarbonyl group or a derivative thereof, and at least one hydrophobic domain, conjugated with the at least one compound interactive domain, wherein the at least one compound interactive domain is positioned between the at least one hydrophilic domain and the at least one hydrophobic domain.
15. The formulation of claim 14 wherein the at least one hydrophobic domain comprises at least one lipid, at least one tocopherol, at least one hydrophobic oligomer or at least one hydrophobic polymer.
16. A method of creating a formulation to deliver a compound to a patient, comprising:
providing a carrier agent comprising at least one hydrophilic domain conjugated with at least one compound interactive domain comprising at least one fluorenylmethyloxycarbonyl group or a derivative thereof and at least one hydrophobic domain conjugated with the at least one compound interactive domain, wherein the at least one compound interactive domain is positioned between the at least one hydrophilic domain and the at least one hydrophobic domain, the compound interactive domain being different from the at least one hydrophilic domain and from the at least one hydrophobic domain; and
combining the compound and the carrier agent.
17. The method of claim 16 wherein the at least one hydrophobic domain comprises at least one lipid, at least one tocopherol, at least one hydrophobic oligomer or at least one hydrophobic polymer.