2-pyridinecarboxamide derivatives, compositions containing such compounds, and methods of treatment

1. A compound of formula I:

or a pharmaceutically acceptable salt thereof, wherein:

R 1 is triazol, pyridyl or phenyl, optionally substituted with 1-4 substituents independently selected from: halogen, hydroxy, oxo, C 1-6 alkyl, C 1-6 alkylOC 1-6 alkyl, C 1-6 alkoxy, CN, NR 3 R 4 , C(O) 1-2 C 1-6 alkyl, C 1-6 alkylC(O) 1-2 C 1-6 alkyl or arylC 1-6 alkyl, wherein the alkyl and alkoxy substituents are further optionally substituted by 1-4 substituents independently selected from: halogen or C 1-6 alkyl where said C 1-6 alkyl is optionally substituted by 1-6 halogens;

R 2 is phenyl, optionally substituted with 1-4 substituents independently selected from: halogen, hydroxy, oxo, C 1-6 alkyl, C 1-6 alkylOC 1-6 alkyl, C 1-6 alkoxy, CN, NR 3 R 4 , C(O) 1-2 C 1-6 alkyl, C 1-6 alkylC(O) 1-2 C 1-6 alkyl or arylC 1-6 alkyl, wherein the alkyl and alkoxy substituents are further optionally substituted by 1-4 substituents independently selected from: halogen or C 1-6 alkyl where said C 1-6 alkyl is optionally substituted by 1-6 halogens;

ring A is thiazolyl which, in addition to the -L-T substituent, is further optionally substituted with 1-4 substituents independently selected from: halogen, hydroxy, C 1-6 alkyl, C 1-6 alkylOC 1-6 alkyl, C 1-6 alkoxy, CN, NR 3 R 4 , C(O) 1-2 C 1-6 alkyl or C 1-6 alkylC(O) 1-2 C 1-6 alkyl, wherein the alkyl and alkoxy substituents are further optionally substituted by 1-4 substituents independently selected from: halogen, C 1-6 alkyl or C 1-6 alkoxy where the alkyl and alkoxy substituents are optionally substituted by 1-6 halogens,

L represents C 1-6 alkyl, C 1-6 alkylOC 1-6 alkyl, C 1-6 alkoxy, NR 3 R 4 , C 1-6 alkylNR 3 R 4 or S(O) 0-2 C 1-6 alkyl, wherein the alkyl and alkoxy groups are further optionally substituted by 1-4 substituents independently selected from: halogen or C 1-6 alkyl where said C 1-6 alkyl is optionally substituted by 1-6 halogens,

T represents CO 2 R, CONR 3 R 4 , or P(O)(OR 5 ) 2 ,

R is hydrogen, and

R 3 , R 4 , and R 5 are individually selected from hydrogen or C 1-6 alkyl.

2. The compound of claim 1 , wherein R 1 is triazolyl, substituted with C 1-6 alkyl optionally substituted by 1-3 halogen; or a pharmaceutically acceptable salt thereof.

3. The compound of claim 1 , wherein R 1 is pyridyl; or a pharmaceutically acceptable salt thereof.

4. The compound of claim 1 , wherein R 1 is phenyl, optionally substituted with 1-4 substituents independently selected from: halogen or C 1-6 alkyl, wherein the alkyl is further optionally substituted by 1-6 halogen substituents; or a pharmaceutically acceptable salt thereof.

5. The compound of claim 1 , wherein R 2 is phenyl, optionally substituted with 1-4 substituents independently selected from: halogen, C 1-6 alkoxy, or C 1-6 alkyl, wherein the alkyl and alkoxy substituents are further optionally substituted by 1-6 halogen substituents; or a pharmaceutically acceptable salt thereof.

6. The compound of claim 1 , wherein L represents C 1-6 alkyl or S(O) 0-2 C 1-6 alkyl, further optionally substituted by 1-6 halogen substituents; or a pharmaceutically acceptable salt thereof.

7. The compound of claim 1 , wherein L represents —SCH 2 —, SC(CH 3 ) 2 —, —SCH 2 C(CH 3 ) 2 —, —CH 2 CH 2 — or —CH 2 —; or a pharmaceutically acceptable salt thereof.

8. A compound which is:

Ethyl ({2-[({3-[(4-methoxyphenyl)sulfanyl]-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}sulfanyl)acetate;

({2-[({3-[(4-methoxyphenyl)sulfanyl]-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}sulfanyl)acetic acid;

3-[(4-methoxyphenyl)sulfanyl]-N-(5-{[2-(methyl amino)-2-oxoethyl]sulfanyl}-1,3-thiazol-2-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamide;

2-({2-[({3-[(4-methoxyphenyl)sulfanyl]-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}sulfanyl)-2-methylpropanoic acid;

Ethyl 3-({2-[({3-[(4-methoxyphenyl)sulfanyl]-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}sulfanyl)-2,2-dimethylpropanoate;

3-({2-[({3-[(4-methoxyphenyl)sulfanyl]-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}sulfanyl)-2,2-dimethylpropanoic acid;

Methyl 3-{2-[({3-[(4-methoxyphenyl)sulfanyl]-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}propanoate;

3-{2-[({3-[(4-Methoxyphenyl)sulfanyl]-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}propanoic acid;

N-[4-(2-Amino-2-oxoethyl)phenyl]-3-[(4-methoxyphenyl)sulfanyl]-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamide;

Ethyl ({2-[({3-[(4-methoxyphenyl)sulfanyl]-6-(pyridin-2-ylsulfanyl)pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}sulfanyl)acetate;

({2-[({3-[(4-Methoxyphenyl)sulfanyl]-6-(pyridin-2-ylsulfanyl)pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}sulfanyl)acetic acid;

Ethyl {5-chloro-2-[({3-[(4-methoxyphenyl)sulfanyl]-6-(pyridin-2-ylsulfanyl)pyridin-2-yl}carbonyl)amino]-1,3-thiazol-4-yl}acetate;

{5-Chloro-2-[({3-[(4-methoxyphenyl)sulfanyl]-6-(pyridin-2-ylsulfanyl)pyridin-2-yl}carbonyl)amino]-1,3-thiazol-4-yl}acetic acid;

Methyl 3-{2-[({3-[(4-methoxyphenyl)sulfanyl]-6-(pyridin-2-ylsulfanyl)pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}propanoate;

3-{2-[({3-[(4-Methoxyphenyl)sulfanyl]-6-(pyridin-2-ylsulfanyl)pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}propanoic acid;

Ethyl {2-[({3-[(4-methoxyphenyl)sulfanyl]-6-(pyridin-2-ylsulfanyl)pyridin-2-yl}carbonyl)amino]-1,3-thiazol-4-yl}acetate;

{2-[({3-[(4-Methoxyphenyl)sulfanyl]-6-(pyridin-2-ylsulfanyl)pyridin-2-yl}carbonyl)amino]-1,3-thiazol-4-yl}acetic acid;

Ethyl ({5-[({3-[(4-fluorophenyl)sulfanyl]-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridin-2-yl}carbonyl)amino]thiophen-2-yl}sulfanyl)acetate;

({2-[({3-[(4-Fluorophenyl)sulfanyl]-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}sulfanyl)acetic acid;

Ethyl 3-({5-[({3-[(4-fluorophenyl)sulfanyl]-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridin-2-yl}carbonyl)amino]thiophen-2-yl}sulfanyl)-2,2-dimethylpropanoate;

3-({2-[({3-[(4-Fluorophenyl)sulfanyl]-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}sulfanyl)-2,2-dimethylpropanoic acid;

Ethyl {2-[({3-[(4-fluorophenyl)sulfanyl]-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}acetate;

{2-[({3-[(4-Fluorophenyl)sulfanyl]-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}acetic acid;

Ethyl {5-chloro-2-[({3-[(4-fluorophenyl)sulfanyl]-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridin-2-yl}carbonyl)amino]-1,3-thiazol-4-yl}acetate;

{5-Chloro-2-[({3-[(4-fluorophenyl)sulfanyl]-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridin-2-yl}carbonyl)amino]-1,3-thiazol-4-yl}acetic acid;

Diethyl ({2-[({3-[(4-fluorophenyl)sulfanyl]-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}methyl)phosphonate;

Ethyl ({5-[({3,6-bis[(4-fluorophenyl)sulfanyl]pyridin-2-yl}carbonyl)amino]thiophen-2-yl}sulfanyl)acetate;

({2-[({3,6-Bis[(4-fluorophenyl)sulfanyl]pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}sulfanyl)acetic acid;

Ethyl {2-[({3,6-bis[(4-fluorophenyl)sulfanyl]pyridin-2-yl}carbonyl)amino]-5-chloro-1,3-thiazol-4-yl}acetate;

{2-[({3,6-Bis[(4-fluorophenyl)sulfanyl]pyridin-2-yl}carbonyl)amino]-5-chloro-1,3-thiazol-4-yl}acetic acid;

Ethyl {5-chloro-2-[({3-[(4-fluorophenyl)sulfanyl]-6-(pyridin-2-ylsulfanyl)pyridin-2-yl}carbonyl)amino]-1,3-thiazol-4-yl}acetate;

{5-Chloro-2-[({3-[(4-fluorophenyl)sulfanyl]-6-(pyridin-2-ylsulfanyl)pyridin-2-yl}carbonyl)amino]-1,3-thiazol-4-yl}acetic acid;

Ethyl {2-[({3-[(4-fluorophenyl)sulfanyl]-6-(pyridin-2-ylsulfanyl)pyridin-2-yl}carbonyl)amino]-1,3-thiazol-4-yl}acetate;

{2-[({3-[(4-Fluorophenyl)sulfanyl]-6-(pyridin-2-ylsulfanyl)pyridin-2-yl}carbonyl)amino]-1,3-thiazol-4-yl}acetic acid;

Ethyl ({2-[({3-[(4-fluorophenyl)sulfanyl]-6-(pyridin-2-ylsulfanyl)pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}sulfanyl)acetate;

({2-[({3-[(4-Fluorophenyl)sulfanyl]-6-(pyridin-2-ylsulfanyl)pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}sulfanyl)acetic acid;

Ethyl 3-({2-[({3-[(4-fluorophenyl)sulfanyl]-6-(pyridin-2-ylsulfanyl)pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}sulfanyl)-2,2-dimethylpropanoate;

3-({2-[({3-[(4-Fluorophenyl)sulfanyl]-6-(pyridin-2-ylsulfanyl)pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}sulfanyl)-2,2-dimethylpropanoic acid;

Methyl 3-{2-[({3-[(4-fluorophenyl)sulfanyl]-6-(pyridin-2-ylsulfanyl)pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}propanoate;

3-{2-[({3-[(4-Fluorophenyl)sulfanyl]-6-(pyridin-2-ylsulfanyl)pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}propanoic acid;

Ethyl (5-chloro-2-{[(6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-3-{[4-(trifluoromethyl)phenyl]sulfanyl}pyridin-2-yl)carbonyl]amino}-1,3-thiazol-4-yl)acetate;

(5-Chloro-2-{[(6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-3-{[4-(trifluoromethyl)phenyl]sulfanyl}pyridin-2-yl)carbonyl]amino}-1,3-thiazol-4-yl)acetic acid;

Ethyl [(2-{[(6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-3-{[4-(trifluoromethyl)phenyl]sulfanyl}pyridin-2-yl)carbonyl]amino}-1,3-thiazol-5-yl)sulfanyl]acetate;

[(2-{[(6-[(4-Methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-3-{[4-(trifluoromethyl)phenyl]sulfanyl}pyridin-2-yl)carbonyl]amino}-1,3-thiazol-5-yl)sulfanyl]acetic acid;

Diethyl [(2-{[(6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-3-{[4-(trifluoromethyl)phenyl]sulfanyl}pyridin-2-yl)carbonyl]amino}-1,3-thiazol-5-yl)methyl]phosphonate;

Ethyl (2-{[(6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-3-{[4-(trifluoromethyl)phenyl]sulfanyl}pyridin-2-yl)carbonyl]amino}-1,3-thiazol-4-yl)acetate;

(2-{[(6-[(4-Methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-3-{[4-(trifluoromethyl)phenyl]sulfanyl}pyridin-2-yl)carbonyl]amino}-1,3-thiazol-4-yl)acetic acid;

Methyl 3-(2-{[(6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-3-{[4-(trifluoromethyl)phenyl]sulfanyl}pyridin-2-yl)carbonyl]amino}-1,3-thiazol-5-yl)propanoate;

3-(2-{[(6-[(4-Methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-3-{[4-(trifluoromethyl)phenyl]sulfanyl}pyridin-2-yl)carbonyl]amino}-1,3-thiazol-5-yl)propanoic acid;

Diethyl ({2-[({3-[(3,4-dichlorophenyl)sulfanyl]-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}methyl)phosphonate;

Ethyl ({2-[({3-[(3,4-dichlorophenyl)sulfanyl]-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}sulfanyl)acetate;

({2-[({3-[(3,4-Dichlorophenyl)sulfanyl]-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridin-2-yl}carbonyl)amino]-1,3-thiazol-5-yl}sulfanyl)acetic acid;

Ethyl {5-chloro-2-[({3-[(3,4-dichlorophenyl)sulfanyl]-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridin-2-yl}carbonyl)amino]-1,3-thiazol-4-yl}acetate;

{5-Chloro-2-[({3-[(3,4-dichlorophenyl)sulfanyl]-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridin-2-yl}carbonyl)amino]-1,3-thiazol-4-yl}acetic acid; or

a pharmaceutically acceptable salt thereof.

9. A pharmaceutical composition comprising the compound of claim 1 , and a pharmaceutically acceptable carrier.

10. A method for the treatment of a condition selected from obesity or diabetes comprising administering to an individual a pharmaceutical composition comprising the compound or pharmaceutically acceptable salt of claim 1 .

11. The method of claim 10 where the compound or pharmaceutically acceptable salt of claim 1 is used in combination with one or more other active ingredients.

12. A method for the treatment of a condition selected from obesity or diabetes comprising administering to an individual a pharmaceutical composition comprising the compound or pharmaceutically acceptable salt of claim 8 .

13. The method of claim 12 where the compound or pharmaceutically acceptable salt of claim 12 is used in combination with one or more other active ingredients.