Supersaturated stabilized nanoparticles for poorly soluble drugs
A pharmaceutical composition and method of producing supersaturated stabilized nanoparticles of poorly soluble drugs having average sizes less than 1 μm, or less than 800 nm, or less than 500 nm, comprising at least one pharmaceutically active ingredient, a hydrophilic polymer, a water-soluble surfactant, and subsequently stabilized by ionic polymers.
1. A stabilized suspension suitable for oral administration and downstream processing of solid dosage forms, consisting of:
a) an aqueous solution consisting of an aqueous solvent, a water-soluble surfactant, a de-agglomeration agent and a water-soluble polymer; and
b) particles of a poorly soluble pharmaceutically active ingredient suspended in the aqueous solution,
wherein the water-soluble surfactant is an anionic surfactant selected from the group consisting of sodium lauryl sulfate, sodium laureth sulfate, docusate salt, sodium stearate, and a combination thereof, the de-agglomeration agent is an anionic polymer that is a copolymer of methacrylic acid and ethyl acrylate, and the water-soluble polymer is hydroxypropyl methylcellulose,
wherein the poorly soluble pharmaceutically active ingredient has an average particle size of about 800 nm or less,
wherein, apart from the water-soluble surfactant and the water-soluble polymer, no other polymer is added to the aqueous solution containing the particles of the poorly soluble pharmaceutically active ingredient before particle size reduction, and
wherein the stabilized suspension provides a supersaturated concentration of the poorly soluble pharmaceutically active ingredient.
2. The stabilized suspension of claim 1 , wherein the ratio of the poorly soluble pharmaceutically active ingredient to the de-agglomeration agent is between 20:1 and 1:20.
3. The stabilized suspension of claim 1 , wherein the ratio of the poorly soluble pharmaceutically active ingredient to the de-agglomeration agent is between 5:1 and 1:5.
4. The stabilized suspension of claim 1 , wherein the ratio of the poorly soluble pharmaceutically active ingredient to the de-agglomeration agent is between 3:1 and 1:3.
5. The stabilized suspension of claim 1 , wherein the particles of the poorly soluble pharmaceutically active ingredient have an average size of about 500 nm or less.
6. The stabilized suspension of claim 1 , wherein the anionic surfactant is selected from the group consisting of docusate salt and sodium lauryl sulfate.
7. A method of treating a patient comprising administering the stabilized suspension of claim 1 .
8. A dry powder consisting of:
a) a water-soluble surfactant, a de-agglomeration agent, and a water-soluble polymer; and
b) particles of a poorly soluble pharmaceutically active ingredient, wherein the water-soluble surfactant is an anionic surfactant selected from the group consisting of sodium lauryl sulfate, sodium laureth sulfate, docusate salt, sodium stearate, and a combination thereof, the de-agglomeration agent is an anionic polymer that is a copolymer of methacrylic acid and ethyl acrylate, and the water-soluble polymer is hydroxypropyl methylcellulose,
wherein the poorly soluble pharmaceutically active ingredient has an average particle size of about 800 nm or less, and
wherein, apart from the water-soluble surfactant and the water-soluble polymer, no other polymer is present before particle size reduction.
9. The dry powder of claim 8 , wherein the dry powder is loaded into a capsule.