Sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine, preparation thereof and use of the same
The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases.
1. A sulphate salt of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof.
2. The sulphate salt of claim 1 , having Formula II
wherein x designates the number of equivalents of sulphuric acid and x is 0.5 to 4, and pharmaceutically acceptable solvates thereof.
3. The sulphate salt of claim 2 and pharmaceutically acceptable solvates thereof, wherein x is 1.5 to 2.5.
4. The sulphate salt of claim 2 and pharmaceutically acceptable solvates thereof, wherein x is 0.5 to 1.5.
5. The sulphate salt of claim 2 and pharmaceutically acceptable solvates thereof, wherein x is 2.5 to 3.5.
6. The sulphate salt of claim 2 , having formula Formula III
wherein
x is as defined in claim 2 , and
y designates the number of equivalents of water and y is 0.5 to 5.
7. A medicament comprising a sulphate salt according to claim 1 , or a pharmaceutically acceptable solvate thereof.