ANTIBODY THERAPY FOR MODULATING FUNCTION OF INTESTINAL RECEPTORS AND METHODS OF TREATING DIABETES AND OBESITY
The present invention provides pharmaceutical compositions formulated for direct delivery to the GI tract of a patient comprising an antibody specific for a target apical intestinal receptor. The present invention further provides methods of treating diseases and conditions in a patient comprising administering directly to the GI tract of the patient, compositions of the present invention wherein modulation of the target apical intestinal receptor by the antibody treats the condition.
1 . A pharmaceutical composition comprising an antibody specific for an apical intestinal receptor in the gastrointestinal tract of a patient, wherein the apical intestinal receptor is a sugar receptor or transporter, wherein the pharmaceutical composition is formulated for direct delivery to the gastrointestinal (GI) tract of the patient, and wherein the antibody is derived from the milk or colostrum of a ruminant animal.