Azaquinazoline inhibitors of atypical protein kinase C

1. A compound of formula (I)

or a salt thereof, wherein:

G is a group of formula

X is chosen from the group consisting of halogen, —CN, —C(═O)R 28 , —C(═O)OR 28 , —C(═O)NR 24 R 28 , —C(═O)C(═O)R 28 , —NR 24 R 28 , —NR 24 NR 24 R 28 , —N═NR 28 , —NR 24 OR 28 , —NR 24 C(═O)R 28 , —NR 24 C(═O)C(═O)R 28 , —NR 24 C(═O)OR 28 , —NR 24 C(═O)C(═O)OR 28 , —NR 24 C(═O)NR 24 R 28 , —NR 24 C(═O)NR 24 C(═O)R 28 , —NR 24 C(═O)NR 24 C(═O)OR 28 , —NR 24 C(═O)C(═O)NR 24 R 28 , —NR 24 S(═O) 2 R 28 , —NR 24 S(═O) 2 NR 24 R 28 , —OR 28 , —OC(═O)R 28 , —OC(═O)NR 24 R 28 , —OC(═O)OR 28 , —OS(═O)R 28 , —OS(═O) 2 R 28 , —OS(═O) 2 OR 28 , —OS(═O) 2 NR 24 R 28 , —S(═O) n R 28 , —S(═O) 2 NR 24 R 28 , and —S(═O)NR 24 R 28 ;

or X is chosen from the group consisting of C 1-10 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-11 aryl, C 7-16 arylalkyl, C 3-11 cycloalkyl, C 4-17 Cycloalkylalkyl, 3-15 membered heterocycloalkyl, 4-21 membered heterocycloalkylalkyl, 5-15 membered heteroaryl, and 6-21 membered heteroarylalkyl wherein each of the foregoing are optionally substituted by 1-10 R 19 ,

R 1 is chosen from the group consisting of C 3-11 cycloalkyl optionally substituted with 1-10 R 19 , and C 1-6 haloalkyl;

R 2 , R 3 , R 4 , and R 5 , are each independently selected from the group consisting of H, halogen, —CN, —C(═O)R 20 , —C(═O)OR 20 , —C(═O)NR 22 R 23 , —C(═O)C(═O)R 20 , —C(═NR 25 )R 20 , —C(═NR 25 )NR 22 R 23 , —C(═NOH)NR 22 R 23 , —C(═NOR 26 )R 20 , —C(═NNR 22 R 23 )R 20 , —C(═NNR 24 C(═O)R 21 )R 20 , —C(═NNR 24 C(═O)OR 21 )R 20 , —C(═S)NR 22 R 23 , —NC, —NO 2 , —NR 22 R 23 , —NR 24 NR 22 R 23 , —N═NR 24 , —NR 24 OR 26 , —NR 24 C(═O)R 20 , —NR 24 C(═O)C(═O)R 20 , —NR 24 C(═O)OR 21 , —NR 24 C(═O)C(═O)OR 21 , —NR 24 C(═O)NR 22 R 23 , —NR 24 C(═O)NR 24 C(═O)R 20 , —NR 24 C(═O)NR 24 C(═O)OR 20 , —NR 24 C(═NR 25 )NR 22 R 23 , —NR 24 C(═O)C(═O)NR 22 R 23 , —NR 24 C(═S)R 20 , —NR 24 C(═S)OR 20 , —NR 24 C(═S)NR 22 R 23 , —NR 24 S(═O) 2 R 21 , —NR 24 S(═O) 2 NR 22 R 23 , —NR 24 P(═O)R 38 R 38 , —NR 24 P(═O)(NR 22 R 23 )(NR 22 R 23 ), —NR 24 P(═O)(OR 20 )(OR 2 ), —NR 24 P(═O)(SR 20 )(SR 2 ), —OR 20 , —OCN, —OC(═O)R 20 , —OC(═O)NR 22 R 23 , —OC(═O)OR 20 , —OC(═NR 25 )NR 22 R 23 , —OS(═O)R 20 , —OS(═O) 2 R 20 , —OS(═O) 20 R 20 , —OS(═O) 2 NR 22 R 23 , —OP(═O)R 38 R 38 , —OP(═O)(NR 22 R 23 )(NR 22 R 23 ), —OP(═O)(OR 20 )(OR 20 ), —OP(═O)(SR 20 )(SR 20 ), —Si(R 24 ) 3 , —SCN, —S(═O) n R 20 , —S(═O) 2 OR 20 , —SO 3 R 27 , —S(═O) 2 NR 22 R 23 , —S(═O)NR 22 R 23 , —SP(═O)R 38 R 38 , —SP(═O)(NR 22 R 23 )(NR 22 R 23 ), —SP(═O)(OR 20 )(OR 20 ), —SP(═O)(SR 20 )(SR 20 ), —P(═O)R 38 R 38 , —P(═O)(NR 22 R 23 )(NR 22 R 23 ), —P(═O)(OR 20 )(OR 20 ), and —P(═O)(SR 20 )(SR 20 );

or R 2 , R 3 , R 4 , and, R 5 , are each independently selected from the group consisting of C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-11 aryl, C 7-16 arylalkyl, C 3-11 cycloalkyl, C 4-17 cycloalkylalkyl, 3-15 membered heterocycloalkyl, 4-21 membered heterocycloalkylalkyl, 5-15 membered heteroaryl, and 6-21 membered heteroarylalkyl wherein each of the foregoing groups may be optionally substituted with 1-10 R 19 ,

or any of R 2 and R 3 or R 4 and R 5 can, together with the atoms to which they are attached, form a C 6-11 aryl, C 3-11 cycloalkyl, 3-15 membered heterocycloalkyl or a 5-15 membered heteroaryl wherein each of the foregoing groups may be optionally substituted by 1-10 R 19 ;

R 19 at each occurrence is independently chosen from the group consisting of C 1-6 alkyl optionally substituted by 1-13 R 39 , C 2-6 alkenyl optionally substituted by 1-11 R 39 , C 2-6 alkynyl optionally substituted by 1-9 R 39 , C 6-11 aryl optionally substituted by 1-11 R 39 , C 7-16 arylalkyl optionally substituted by 1-19 R 39 , C 3-11 cycloalkyl optionally substituted by 1-21 R 39 , C 4-17 cycloalkylalkyl optionally substituted by 1-32 R 39 , 3-15 membered heterocycloalkyl optionally substituted by 1-28 R 39 , 4-21 membered heterocycloalkylalkyl optionally substituted by 1-40 R 39 , 5-15 membered heteroaryl optionally substituted by 1-15 R 39 , 6-21 membered heteroarylalkyl optionally substituted by 1-27 R 39 , halogen, —CN, —C(═O)R 30 , —C(═O)OR 30 , —C(═O)NR 32 R 33 , —C(═O)C(═O)R 30 , —C(═NR 35 )R 30 , —C(═NR 35 )NR 32 R 33 , —C(═NOH)NR 32 R 33 , —C(═NOR 36 )R 30 , —C(═NNR 32 R 33 )R 30 , —C(═NNR 34 C(═O)R 31 )R 30 , —C(═NNR 34 C(═O)OR 31 )R 30 , —C(═S)NR 32 R 33 , —NC, —NO 2 , —NR 32 R 33 , —NR 34 NR 32 R 33 , —N═NR 34 , ═NR 30 , ═NOR 30 , —NR 34 OR 36 , —NR 34 C(═O)R 30 , —NR 34 C(═O)C(═O)R 30 , —NR 34 C(═O)OR 31 , —NR 34 C(═O)C(═O)OR 31 , —NR 34 C(═O)NR 32 R 33 , —NR 34 C(═O)NR 34 C(═O)R 30 , —NR 34 C(═O)NR 34 C(═O)OR 30 , —NR 34 C(═NR 35 )NR 32 R 33 , —NR 34 C(═O)C(═O)NR 32 R 33 , —NR 34 C(═S)R 30 , —NR 34 C(═S)OR 30 , —NR 34 C(═S)NR 32 R 33 , —NR 34 S(═O) 2 R 31 , —NR 34 S(═O) 2 NR 32 R 33 , —NR 34 P(═O)R 38 R 38 , —NR 34 P(═O)(NR 32 R″)(NR 32 R″), —NR 34 P(═O)(OR 30 )(OR 30 ), —NR 34 P(═O)(SR 30 )(SR 30 ), —OR 30 , ═O, —OCN, —OC(═O)R 30 , —OC(═O)NR 32 R 33 , —OC(═O)OR 30 ), —OC(═NR 35 )NR 32 R 33 , —OS(═O)R 30 , —OS(═O) 2 R 30 , —OS(═O) 2 OR 30 , —OS(═O) 2 NR 32 R 33 , —OP(═O)R 38 R 38 , —OP(═O)(NR 32 R 33 )(NR 32 R 33 ), —OP(═O)(OR 30 )(OR 30 ), —OP(═O)(SR 30 )(SR 30 ), —Si(R 34 ) 3 , —SCN, ═S, —S(═O),R 30 , —S(═O) 2 OR 30 , —SO 3 R 37 , —S(═O) 2 NR 32 R 33 , —S(═O)NR 32 R 33 , —SP(═O)R 38 R 38 , —SP(═O)(NR 32 R 33 )(NR 32 R 33 ), —SP(═O)(OR 30 )(OR 30 ), —SP(═O)(SR 30 )(SR 30 ), —P(═O)R 38 R 38 , —P(═O)(NR 32 R 33 )(NR 32 R 33 ), —P(═O)(OR 30 )(OR 30 ), and —P(═O)(SR 30 )(SR 30 );

R 20 , R 21 , R 24 , R 25 , R 26 , R 27 , R 30 , R 31 , R 34 , R 35 , R 36 and R 37 at each occurrence is independently chosen from the group consisting of H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-11 aryl, C 7-16 arylalkyl, C 3-11 cycloalkyl, C 4-17 Cycloalkylalkyl, 3-15 membered heterocycloalkyl, 4-21 membered heterocycloalkylalkyl, 5-15 membered heteroaryl, and 6-21 membered heteroarylalkyl wherein each of the foregoing groups (except for Hydrogen) may be optionally substituted by 1-10 R 19 ;

R 28 at each occurrence is independently chosen from the group consisting of C 1-10 alkyl, C 2-10 alkenyl, C 2-6 alkynyl, C 6-11 aryl, C 7-16 arylalkyl, C 3-11 cycloalkyl, C 4-17 cycloalkylalkyl, 3-15 membered heterocycloalkyl, 4-21 membered heterocycloalkylalkyl, 5-15 membered heteroaryl, and 6-21 membered heteroarylalkyl wherein each of the foregoing groups may be optionally substituted by 1-10 R 19 ;

R 22 , R 23 , R 32 and R 33 at each occurrence is independently chosen from the group consisting of H, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-11 aryl, C 7-16 arylalkyl, C 3-11 cycloalkyl, C 4-17 cycloalkylalkyl, 3-15 membered heterocycloalkyl, 4-21 membered heterocycloalkylalkyl, 5-15 membered heteroaryl, and 6-21 membered heteroarylalkyl wherein each of the foregoing groups (except for Hydrogen) may be optionally substituted by 1-10 R 19 ;

or any R 22 and R 23 and/or R 32 and R 33 may form, together with the nitrogen atom to which they are attached, a 3-15 membered heterocycloalkyl optionally substituted by 1-10 R 19 or a 5-15 membered heteroaryl optionally substituted by 1-10 R 19 ;

R 38 at each occurrence is independently chosen from the group consisting of C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-11 aryl, C 7-16 arylalkyl, C 3-11 cycloalkyl, C 4-17 cycloalkylalkyl, 3-15 membered heterocycloalkyl, 4-21 membered heterocycloalkylalkyl, 5-15 membered heteroaryl, and 6-21 membered heteroarylalkyl wherein each of the foregoing groups may be optionally substituted by 1-10 R 19 ;

or any two R 38 attached to the same phosphorus atom can, together with the phosphorus atom linking them, form a 3-10 membered heterocycloalkyl optionally substituted by 1-6 R 19 ;

R 39 at each occurrence is independently chosen from the group consisting of C 1-6 alkyl optionally substituted by 1-13 halogen, C 2-6 alkenyl, C 2-6 alkynyl, C 6-11 aryl, C 7-16 arylalkyl, C 3-11 cycloalkyl, C 4-17 cycloalkylalkyl, 3-15 membered heterocycloalkyl, 4-21 membered heterocycloalkylalkyl, 5-15 membered heteroaryl, 6-21 membered heteroarylalkyl, halogen, —CN, —C(═O)R 40 , —C(═O)OR 40 , —C(═O)NR 40 R 40 , —C(═O)C(═O)R 40 , —C(═NR 40 )R 40 , —C(═NR 40 )NR 40 R 40 , —C(═NOH)NR 40 R 40 , —C(═NOR 40 )R 40 , —C(═NNR 40 R 40 )R 40 , —C(═NNR 40 C(═O)R 40 )R 40 , —C(═NNR 40 )C(═O)OR 40 )R 40 , —C(═S)NR 40 R 40 , —NC, —NO 2 , —NR 40 )R 40 , —NR 40 NR 40 R 40 , —N═NR 40 , ═NR 40 , ═NOR 40 , —NR 40 OR 40 , —NR 40 C(═O)R 40 , —NR 40 C(═O)C(═O)R 40 , —NR 40 C(═O)OR 40 , —NR 40 C(═O)C(═O)OR 40 , —NR 40 C(═O)NR 40 R 40 , —NR 40 C(═O)NR 40 C(═O)R 40 , —NR 40 C(═O)NR 40 C(═O)OR 40 , —NR 40 C(═NR 40 )NR 40 R 40 , —NR 40 C(═O)C(═O)NR 40 R 40 , —NR 40 C(═S)R 40 , —NR 40 C(═S)OR 40 , —NR 40 C(═S)NR 40 R 40 , —NR 40 S(═O) 2 R 40 , —NR 40 S(═O) 2 NR 40 R 40 , —NR 40 P(═O)R 41 R 41 , —NR 40 P(═O)(NR 40 R 40 )(NR 40 R 40 ), —NR 40 P(═O)(OR 40 )(OR 40 ), —NR 40 P(═O)(SR 40 )(SR 40 ), —OR 40 , ═O, —OCN, —OC(═O)R 40 , —OC(═O)NR 40 R 40 , —OC(═O)OR 40 , —OC(═NR 40 )NR 40 R 40 , —OS(═O)R 40 , —OS(═O) 2 R 40 , —OS(═O) 20 R 40 , —OS(═O) 2 NR 40 )R 40 , —OP(═O)R 41 R 41 , —OP(═O)(NR 40 R 40 )(NR 40 R 40 , —OP(═O)(OR 40 )(OR 40 , —OP(═O)(SR 40 )(SR 40 ), —Si(R 40 ) 3 , —SCN, ═S, —S(═O) n R 40 , —S(═O) 20 R 40 , —SO 3 R 40 , —S(═O) 2 NR 40 R 40 , —S(═O)NR 40 R 40 , —SP(═O)R 41 R 41 , —SP(═O)(NR 40 R 40 )(NR 40 R 40 ), —SP(═O)(OR 40 )(OR 40 ), —SP(═O)(SR 40 )(SR 40 ), —P(═O)R 41 R 41 , —P(═O)(NR 40 R 40 )(NR 40 R 40 ), —P(═O)(OR 40 )(OR 40 ), and —P(═O)(SR 40 )(SR 40 );

R 40 at each occurrence is independently chosen from the group consisting of H, C 1-6 alkyl, and C 1-6 -haloalkyl;

R 41 at each occurrence is independently chosen from the group consisting of C 1-6 alkyl and C 1-6 -haloalkyl; and

n at each occurrence is independently selected from the group consisting of 0, 1, and 2.

2. The compound according to claim 1 , wherein R 1 is optionally substituted cyclopropyl.

3. The compound according to claim 1 , wherein R 1 is optionally substituted cyclobutyl.

4. The compound according to claim 1 , wherein R 1 is C 1-6 -haloalkyl.

5. The compound according to claim 1 , wherein G is

6. The compound according to claim 1 , wherein G is

7. The compound according to claim 1 , wherein G is

8. The compound according to claim 1 , wherein X is chosen from the group consisting of 3-10 membered heterocycloalkyl optionally substituted by 1-6 R 19 , 5-10 membered heteroaryl optionally substituted by 1-6 R 19 , —C(═O)R 28 , —C(═O)NR 24 R 28 , —NR 24 R 28 , —NR 24 C(═O)R 28 , —NR 24 S(═O) 2 R 28 , —OC(═O)OR 28 , —OS(═O)R 28 , —OS(═O) 2 R 28 , and —OR 28 .

9. The compound according to claim 8 , wherein X is chosen from the group consisting of 3-10 membered heterocycloalkyl optionally substituted by 1-6 R 19 , 5-10 membered heteroaryl optionally substituted by 1-6 R 19 , and —OR 28 .

10. The compound according to claim 1 , wherein R 2 and R 3 are each independently chosen from the group consisting of H, halogen, —CN, —C(═O)R 20 , —C(═O)OR 20 , —C(═O)NR 22 R 23 , —C(═O)C(═O)R 20 , —C(═NR 25 )R 20 , —C(═NR 25 )NR 22 R 23 , —C(═NOH)NR 22 R 23 , —C(═NOR 26 )R 20 , —C(═NNR 22 R 23 )R 20 , —C(═NNR 24 C(═O)R 21 )R 20 , —C(═NNR 24 C(═O)OR 21 )R 20 , —C(═S)NR 22 R 23 , —NC, —NO 2 , —NR 22 R 23 , —NR 24 NR 22 R 23 , —N═NR 24 , —NR 24 OR 26 , —NR 24 C(═O)R 20 , —NR 24 C(═O)C(═O)R 20 , —NR 24 C(═O)OR 21 , —NR 24 C(═O)C(═O)OR 21 , —NR 24 C(═O)NR 22 R 23 , —NR 24 C(═O)NR 24 C(═O)R 20 , —NR 24 C(═O)NR 24 C(═O)OR 20 , —NR 24 C(═NR 25 )NR 22 R 23 , —NR 24 C(═O)C(═O)NR 22 R 23 , —NR 24 C(═S)R 20 , —NR 24 C(═S)OR 20 , —NR 24 C(═S)NR 22 R 23 , —NR 24 S(═O) 2 R 21 , —NR 24 S(═O) 2 NR 22 R 23 , —NR 24 P(═O)R 38 R 38 , —NR 24 P(═O)(NR 22 R 23 )(NR 22 R 23 ), OR 20 , —OCN, —OC(═O)R 20 , —OC(═O)NR 22 R 23 , —OC(═O)OR 20 , —OC(═NR 25 )NR 22 R 23 , —OS(═O)R 20 , —OS(═O) 2 R 20 , —OS(═O) 2 OR 20 , —OS(═O) 2 NR 22 R 23 , —S(═O) n R 20 , —S(═O) 2 OR 20 , —SO 3 R 27 , S(═O) 2 NR 22 R 23 , and —S(═O)NR 22 R 23 ;

or R 2 and R 3 are each independently chosen from the group consisting of C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-11 aryl, C 7-16 arylalkyl, C 3-11 cycloalkyl, C 4-17 cycloalkylalkyl, 3-15 membered heterocycloalkyl, 4-21 membered heterocycloalkylalkyl, 5-15 membered heteroaryl, and 6-21 membered heteroarylalkyl wherein each of the foregoing groups may be optionally substituted with 1-10 R 19 .

11. The compound according to claim 10 , wherein R 2 and R 3 are each independently chosen from the group consisting of H, halogen, —S(═O)R 20 , —C(═O)NR 22 R 23 , NR 24 S(═O) 2 R 21 , and —NR 22 R 23 ; or R 2 and R 3 are each independently chosen from the group consisting of C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-11 aryl, C 7-16 arylalkyl, C 3-11 cycloalkyl, C 4-17 cycloalkylalkyl, 3-15 membered heterocycloalkyl, 4-21 membered heterocycloalkylalkyl, 5-15 membered heteroaryl, and 6-21 membered heteroarylalkyl wherein each of the foregoing groups may be optionally substituted with 1-10 R 19 .

12. The compound according to claim 1 , wherein R 2 and R 3 are taken together with the atoms to which they are attached to form a C 6-11 aryl,

C 3-11 cycloalkyl, 3-15 membered heterocycloalkyl, or a 5-15 membered heteroaryl wherein each of the foregoing groups may be optionally substituted by 1-10 R 19 .

13. The compound according to claim 1 , wherein R 1 is optionally substituted cyclopropyl and G is

14. The compound according to claim 1 , wherein R 1 is optionally substituted cyclobutyl and G is

15. The compound according to claim 1 , wherein R 1 is optionally substituted cyclopropyl and G is

16. The compound according to claim 1 , wherein R 1 is optionally substituted cyclobutyl and G is

17. The compound according to claim 1 , wherein R 1 is optionally substituted cyclopropyl and G is

18. The compound according to claim 1 , wherein R 1 is optionally substituted cyclobutyl and G is

19. The compound according to claim 1 , wherein R 1 is C 1-6 -haloalkyl and G is

20. The compound according to claim 1 , wherein R 1 is C 1-6 -haloalkyl and G is

21. The compound according to claim 1 , wherein R 1 is C 1-6 -haloalkyl and G is

22. The compound according to claim 19 , wherein R 1 is trifluoromethyl.

23. The compound according to claim 13 , wherein X is chosen from the group consisting of 3-10 membered heterocycloalkyl optionally substituted by 1-6 R 19 , 5-10 membered heteroaryl optionally substituted by 1-6 R 19 , —C(═O)R 28 , —C(═O)NR 24 R 28 , —NR 24 R 28 , —NR 24 C(═O)R 28 , —NR 24 S(═O) 2 R 28 , —OS(═O)R 28 , —OS(═O) 2 R 28 , and —OR 28 .

24. The compound according to claim 1 , wherein R 2 , R 3 , R 4 and R 5 are all H.

25. The compound according to claim 1 , wherein R 4 and R 5 are H.

26. The compound according to claim 13 , wherein R 2 and R 3 are each independently chosen from the group consisting of H, halogen, —S(═O) n R 20 , —C(═O)NR 22 R 23 , —NR 24 S(═O) 2 R 21 , and —NR 22 R 23 ; or R 2 and R 3 are each independently chosen from the group consisting of C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 6-11 aryl, C 7-16 arylalkyl, C 3-11 cycloalkyl, C 4-17 cycloalkylalkyl, 3-15 membered heterocycloalkyl, 4-21 membered heterocycloalkylalkyl, 5-15 membered heteroaryl, and 6-21 membered heteroarylalkyl wherein each of the foregoing groups may be optionally substituted with 1-10 R 19 .

27. The compound according to claim 26 , wherein R 4 and R 5 are H.

28. The compound according to claim 1 that is:

{5-Cyclopropyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-methyl-amine;

{5-Cyclobutyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-methyl-amine;

4-(5-Cyclobutyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-2-methyl-8H-1,3a,7,8-tetraaza-cyclopenta[a] indene;

{(S)-1-[5-Cyclopropyl-2-(2-trifluoromethyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-piperazin-2-yl}-methanol;

{(S)-1-[5-Cyclobutyl-2-(2-trifluoromethyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-piperazin-2-yl}-methanol;

{(R)-1-[5-Cyclopropyl-2-(2-trifluoromethyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-piperazin-2-yl}-methanol;

{(R)-1-[5-Cyclobutyl-2-(2-trifluoromethyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-piperazin-2-yl}-methanol;

(±)-5-Cyclopropyl-4-(4,7-cis)-octahydro-pyrrolo [3,4-b]pyridin-1-yl-2-(2-trifluoromethyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidine;

4-((R)-5-Cyclobutyl-4-(R)-hexahydro-pyrrolo [3,4-b]pyrrol-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-9H-pyrido[2,3-b]indole;

4-((S)-5-Cyclobutyl-4-(S)-hexahydro-pyrrolo [3,4-b]pyrrol-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-9H-pyrido[2,3-b]indole;

trans-N-[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-cyclobutane-1,3-diamine;

trans-N-{5-Cyclopropyl-2-[2-(2,2-difluoro-1-methyl-cyclopropyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-cyclohexane-1,4-diamine;

3-[4-(5-Cyclobutyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-1H-pyrrolo [2,3-b]pyridin-2-yl]-tetrahydro-thiophen-3-ol;

5-Cyclopropyl-2-(2-phenylsulfanyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-4-piperazin-1-yl-pyrido [3,4-d]pyrimidine;

[5-Cyclopropyl-2-(2-phenylsulfanyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-methyl-piperidin-4-yl-amine;

5-Cyclopropyl-2-(2-methylsulfanyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-4-piperazin-1-yl-pyrido[3,4-d]pyrimidine;

5-Cyclobutyl-2-(2-methylsulfanyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-4-piperazin-1-yl-pyrido[3,4-d]pyrimidine;

5-Cyclopropyl-2-[2-(2,4-dichloro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-4-piperazin-1-yl-pyrido[3,4-d]pyrimidine;

(±)-5-Cyclopropyl-4-(3,6-cis)-hexahydro-pyrrolo [3,2-b]pyrrol-1-yl-2-(2-trifluoromethyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidine;

5-Cyclopropyl-4-(3 aS,6aS)-hexahydro-pyrrolo [3,4-b]pyrrol-1-yl-2-(2-trifluoromethyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidine;

5-Cyclopropyl-4-(3 aR,6aR)-hexahydro-pyrrolo [3,4-b]pyrrol-1-yl-2-(2-trifluoromethyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidine;

Azepan-4-yl-[5-cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-amine;

{5-Cyclopropyl-2-[2-(2-methoxy-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-methyl-amine;

{5-Cyclopropyl-2-[2-(2,4-dichloro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-methyl-amine;

(1R,5S,8R)-3-Aza-bicyclo [3.2.1] oct-8-yl-{2-[2-(2-chloro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-5-cyclopropyl-pyrido[3,4-d]pyrimidin-4-yl}-amine;

(1R,5S,8S)-3-Aza-bicyclo [3.2.1] oct-8-yl-{2-[2-(2-chloro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-5-cyclopropyl-pyrido[3,4-d]pyrimidin-4-yl}-amine;

(±)-2-[2-(2-Chloro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-5-cyclopropyl-4-(3 aR,7aS)-octahydro-pyrrolo [3,2-c]pyridin-1-yl-pyrido[3,4-d]pyrimidine;

[5-Cyclobutyl-2-(2-phenylsulfanyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido [3,4-d]pyrimidin-4-yl]-methyl-piperidin-4-yl-amine;

[5-Cyclopropyl-2-(2-phenylsulfanyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-(3,3-dimethyl-piperidin-4-yl)-methyl-amine;

4-(5-Cyclobutyl-4-methoxy-pyrido[3,4-d]pyrimidin-2-yl)-9H-pyrido[2,3-b] indole;

[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-(3,3-dimethyl-piperidin-4-yl)-methyl-amine;

{2-[2-(2-tert-Butyl-thiazol-4-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-5-cyclopropyl-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-methyl-amine;

(2R,6S)-3-Aza-bicyclo[3.1.0]hex-6-yl-[(S)-5-cyclobutyl-2-(9H-pyrido[2,3-b] indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-amine;

(±)-2-[2-(2-tert-Butyl-thiazol-4-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-5-cyclopropyl-4-(3,6-cis)-hexahydro-pyrrolo [3,2-b]pyrrol-1-yl-pyrido[3,4-d]pyrimidine;

{5-Cyclopropyl-2-[2-(pyrazolo [1,5-a]pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(pyrazolo [1,5-a]pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-methyl-amine;

[4-(5-Cyclopropyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-pyridin-2-yl]-(4-cyclopropyl-thiazol-2-yl)-amine;

[4-(5-Cyclobutyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-pyridin-2-yl]-(4-cyclopropyl-thiazol-2-yl)-amine;

{5-Cyclopropyl-2-[2-(4-cyclopropyl-thiazol-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

5-Cyclopropyl-2-[2-(2,6-difluoro-pyridin-3-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-4-piperazin-1-yl-pyrido[3,4-d]pyrimidine;

5-Cyclopropyl-2-[2-(5-methyl-thiophen-2-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-4-piperazin-1-yl-pyrido[3,4-d]pyrimidine;

5-Cyclopropyl-2-[2-(5-methyl-furan-2-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-4-piperazin-1-yl-pyrido[3,4-d]pyrimidine;

5-Cyclopropyl-2-[2-(2-fluoro-pyridin-3-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-4-piperazin-1-yl-pyrido[3,4-d]pyrimidine;

Azepan-4-yl-[5-cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-methyl-amine;

{5-Cyclopropyl-2-[2-(2,5-dichloro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-methyl-amine;

5-Cyclopropyl-2-[2-(2,5-dichloro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-4-piperazin-1-yl-pyrido[3,4-d]pyrimidine;

[5-Cyclopropyl-2-(2-phenylamino-pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-(3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(5-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(3-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(4-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(4-trifluoromethyl-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

(4-tert-Butyl-thiazol-2-yl)-[4-(5-cyclopropyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-pyridin-2-yl]-amine;

{5-Cyclopropyl-2-[2-(4-cyclopropyl-thiazol-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-methyl-amine;

(±)-5-cyclobutyl-4-(3,6-cis)-hexahydro-pyrrolo [3,2-b]pyrrol-1-yl-2-(2-trifluoromethyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidine;

{3-[4-(5-Cyclobutyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-1H-pyrrolo [2,3-b]pyridin-2-yl]-prop-2-ynyl}-dimethyl-amine;

(±)-5-Cyclopropyl-2-[2-(3-fluoro-pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-4-(3,6-cis)-hexahydro-pyrrolo [3,2-b]pyrrol-1-yl-pyrido[3,4-d]pyrimidine;

(±)-5-Cyclobutyl-2-[2-(3-fluoro-pyridin-2-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-4-(3,6-cis)-hexahydro-pyrrolo [3,2-b]pyrrol-1-yl-pyrido[3,4-d]pyrimidine;

5-Cyclopropyl-4-piperazin-1-yl-2-(2-pyridin-3-yl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidine;

4 [5-Cyclobutyl-4-(hexahydro-pyrrolo [3,2-b]pyrrol-1-yl)-pyrido[3,4-d]pyrimidin-2-yl]-9H-pyrido[2,3-b]indole;

N-[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-cyclopentane-1,3-diamine;

[5-Cyclopropyl-2-(2-pyridin-3-yl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-(3,3-dimethyl-piperidin-4-yl)-methyl-amine;

4-(5-Cyclopropyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-1H-pyrrolo [2,3-b]pyridine-2-carboxylic acid cyclohexylamide;

(±)-5-cyclopropyl-4-(3,7-cis)-octahydro-pyrrolo [3,2-b]pyridin-1-yl-2-(2-trifluoromethyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidine;

5-Cyclopropyl-4-(octahydro-[1,5]naphthyridin-1-yl)-2-(2-trifluoromethyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidine;

N-[4-(5-Cyclopropyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-pyridin-2-yl]-4-fluoro-benzenesulfonamide;

4-{5-Cyclopropyl-4-[(3,3-dimethyl-piperidin-4-yl)-methyl-amino]-pyrido[3,4-d]pyrimidin-2-yl}-1H-pyrrolo [2,3-b]pyridine-2-carboxylic acid cyclohexylamide;

{5-Cyclobutyl-2-[2-(5-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(3,5-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(4-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(3-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(3,5,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

{2-[2-(4-tert-Butyl-thiazol-2-ylamino)-pyridin-4-yl]-5-cyclobutyl-pyrido [3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

4-[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-ylamino]-azepan-3-ol;

N-[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-N-methyl-cyclobutane-1,3-diamine;

N-[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-N-methyl-cyclobutane-1,3-diamine;

(±)-(3aS,7aS)-1 [5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-octahydro-pyrrolo [3,2-c]pyridin-3a-ol;

(±)-(3,4-trans)-4-{[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-methyl-amino}-3-methyl-piperidin-3-ol; N-[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-N-methyl-cyclopentane-1,3-diamine;

4-(5-Cyclopropyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-1H-pyrrolo [2,3-b]pyridine-2-carboxylic acid methylamide;

(±)-5-cyclobutyl-4-(3,7-cis)-octahydro-pyrrolo [3,2-b]pyridin-1-yl-2-(2-trifluoromethyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidine;

5-Cyclobutyl-4-(octahydro-[1,5]naphthyridin-1-yl)-2-(2-trifluoromethyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidine;

(±)-5-cyclopropyl-4-(3,6-cis)-hexahydro-pyrrolo [3,2-b]pyrrol-1-yl-2-(2-methyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidine;

(±)-5-cyclopropyl-2-(2-methyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-4-(3,7-cis)-octahydro-pyrrolo [3,2-b]pyridin-1-yl-pyrido[3,4-d]pyrimidine;

(±)-5-cyclobutyl-4-(3,6-cis)-hexahydro-pyrrolo [3,2-b]pyrrol-1-yl-2-(2-methyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidine;

(±)-5-Cyclobutyl-2-(2-methyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-4-(3,7-cis)-octahydro-pyrrolo [3,2-b]pyridin-1-yl-pyrido[3,4-d]pyrimidine;

{5-Cyclobutyl-2-[2-(quinolin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(3,4,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

{2-[2-(5-Chloro-3-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-5-cyclobutyl-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(isoquinolin-1-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(4-trifluoromethoxy-phenylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

[5-Cyclobutyl-2-(2-phenylamino-pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-(3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(2-fluoro-pyridin-3-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(2,6-difluoro-phenylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

5-Cyclopropyl-2-(2-methyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-4-(octahydro-[1,5] naphthyridin-1-yl)-pyrido[3,4-d]pyrimidine;

5-Cyclobutyl-2-(2-methyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-4-(octahydro-[1,5]naphthyridin-1-yl)-pyrido[3,4-d]pyrimidine;

{5-Cyclobutyl-2-[2-(2,6-difluoro-benzylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

{4-[5-Cyclobutyl-4-(hexahydro-pyrrolo [3,2-b]pyrrol-1-yl)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-yl}-(3,6-difluoro-pyridin-2-yl)-amine;

{4-[5-Cyclobutyl-4-(hexahydro-pyrrolo [3,2-b]pyrrol-1-yl)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-yl}-(3,5,6-trifluoro-pyridin-2-yl)-amine;

4 [5-Cyclopropyl-4-(octahydro-pyrrolo [3,2-c]pyridin-1-yl)-pyrido[3,4-d]pyrimidin-2-yl]-1H-pyrrolo [2,3-b]pyridine-2-carboxylic acid methylamide;

[5-Cyclopropyl-2-(2-methyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-(3,3-dimethyl-piperidin-4-yl)-amine;

[5-Cyclobutyl-2-(2-methyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-(3,3-dimethyl-piperidin-4-yl)-amine;

{4-[5-Cyclobutyl-4-(hexahydro-pyrrolo [3,2-b]pyrrol-1-yl)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-yl}-phenyl-amine;

5-Cyclopropyl-2-[2-(2,5-dichloro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-4-(hexahydro-pyrrolo [3,2-b]pyrrol-1-yl)-pyrido[3,4-d]pyrimidine;

(±)-(3 aS,7aS)-1-[5-Cyclopropyl-2-(2-trifluoromethyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-octahydro-pyrrolo [3,2-c]pyridin-3a-ol;

{5-Cyclobutyl-2-[2-(4,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(3,5,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-methyl-amine;

2-{4-[5-Cyclobutyl-4-(3,3-dimethyl-piperidin-4-ylamino)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-ylamino}-isonicotinonitrile;

(1S,6S)-3-Aza-bicyclo[3.1.0]hex-6-yl-{(R)-5-cyclobutyl-2-[2-(3,5,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-amine;

(1S,6S)-3-Aza-bicyclo [3.1.0]hex-6-yl-{(R)-5-cyclobutyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-amine;

[5-Cyclobutyl-2-(2-phenylamino-pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-(3,3-dimethyl-piperidin-4-yl)-methyl-amine;

(1S,6S)-3-Aza-bicyclo [3.1.0]hex-6-yl-[(R)-5-cyclobutyl-2-(2-phenylamino-pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-amine;

5-Cyclopropyl-2-[2-(2-methoxy-thiazol-4-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-4-piperazin-1-yl-pyrido[3,4-d]pyrimidine;

(±)-(3aS,7aS)-1-[5-Cyclopropyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-octahydro-pyrrolo [3,2-c]pyridin-3a-ol;

(±)-(3,4-trans)-4-{[5-Cyclopropyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-methyl-amino}-3-methyl-piperidin-3-ol;

[5-Cyclopropyl-2-(2-methyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-(3,3-dimethyl-piperidin-4-yl)-methyl-amine;

[5-Cyclobutyl-2-(2-methyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-(3,3-dimethyl-piperidin-4-yl)-methyl-amine;

(±)-(3 aS,7aS)-1-[5-Cyclobutyl-2-(2-methyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-octahydro-pyrrolo [3,2-c]pyridin-3a-ol;

5-Cyclopropyl-2-[2-(2-methoxy-thiazol-4-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-4-(octahydro-pyrrolo [3,2-c]pyridin-1-yl)-pyrido[3,4-d]pyrimidine;

[5-Cyclopropyl-2-(2-methylsulfanyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-methyl-piperidin-4-yl-amine;

5-Cyclobutyl-2-(2-methanesulfonyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-4-piperazin-1-yl-pyrido [3,4-d]pyrimidine;

cis-[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-cyclobutane-1,3-diamine;

5-[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-ylamino]-azepan-3-ol;

{4-[5-Cyclobutyl-4-(octahydro-pyrrolo [3,2-b]pyridin-1-yl)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-yl}-(3,5,6-trifluoro-pyridin-2-yl)-amine;

{4-[5-Cyclobutyl-4-(octahydro-pyrrolo [3,2-b]pyridin-1-yl)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-yl}-(3,6-difluoro-pyridin-2-yl)-amine;

{4-[5-Cyclobutyl-4-(octahydro-pyrrolo [3,2-b]pyridin-1-yl)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-yl}-phenyl-amine;

{5-Cyclobutyl-2-[2-(3,5,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3-methyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3-methyl-piperidin-4-yl)-amine;

2-[2-(2-Chloro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-5-cyclopropyl-4-(hexahydro-pyrrolo [3,2-b]pyrrol-1-yl)-pyrido[3,4-d]pyrimidine;

2-[2-(2-Chloro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-5-cyclopropyl-4-(octahydro-pyrrolo [3,2-b]pyridin-1-yl)-pyrido[3,4-d]pyrimidine;

2-(2-Chloro-1H-pyrrolo [2,3-b]pyridin-4-yl)-5-cyclobutyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidine;

5-Cyclobutyl-4-piperazin-1-yl-2-(2-pyrimidin-5-yl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidine;

5-Cyclobutyl-2[2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-4-piperazin-1-yl-pyrido[3,4-d]pyrimidine;

5-Cyclobutyl-2-(2-ethylsulfanyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-4-piperazin-1-yl-pyrido[3,4-d]pyrimidine;

5-Cyclopropyl-2-(2-ethylsulfanyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-4-piperazin-1-yl-pyrido[3,4-d]pyrimidine;

[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-(8-oxa-3-aza-bicyclo [3.2.1] oct-6-yl)-amine;

{5-Cyclobutyl-2-[2-(pyrazolo [1,5-a]pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(3,5,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(2,2-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(2,2-dimethyl-piperidin-4-yl)-amine;

2-[2-(4-Chloro-phenyl)-1-pyrrolo [2,3-b]pyridin-4-yl]-5-cyclopropyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidine;

2-[2-(4-Chloro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-5-cyclopropyl-4-(hexahydro-pyrrolo [3,2-b]pyrrol-1-yl)-pyrido[3,4-d]pyrimidine;

(R)-Azepan-4-yl-[5-cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-amine;

5-Cyclopropyl-2-[2-(2,5-dichloro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-4-(octahydro-pyrrolo [3,2-b]pyridin-1-yl)-pyrido[3,4-d]pyrimidine;

(±)-(3 aS,7aS)-1-{2-[2-(2-Chloro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-5-cyclopropyl-pyrido[3,4-d]pyrimidin-4-yl}-octahydro-pyrrolo [3,2-c]pyridin-3a-ol;

{2-[2-(4-Chloro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-5-cyclopropyl-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-methyl-amine;

5-(5-cyclobutyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-3-fluoro-9H-dipyrido[2,3-b;3′,2′-d]pyrrole;

4-[4-Piperazin-1-yl-5-(2,2,2-trifluoro-1-methyl-ethyl)-pyrido[3,4-d]pyrimidin-2-yl]-9H-pyrido[2,3-b] indole;

{5-Cyclobutyl-2-[2-(3,5,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(2-methyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(2-methyl-piperidin-4-yl)-amine;

4-[4-(5-Cyclopropyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-1H-pyrrolo [2,3-b]pyridin-2-yl]-benzamide;

2-Amino-4-[5-cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-ylamino]-cyclopentanol;

(±)-(3 aS,7aS)-1-{5-Cyclopropyl-2-[2-([1,2,4]triazolo [1,5-a]pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-octahydro-pyrrolo[3,2-c]pyridin-3a-ol;

{4-[5-Cyclopropyl-4-(octahydro-pyrrolo [3,2-c]pyridin-1-yl)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-yl}-1,2,4] triazolo [1,5-a]pyridin-2-yl-amine;

[5-Cyclopropyl-2-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

[5-Cyclopropyl-2-(2-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-((R)-3,3-dimethyl-piperidin-4-yl)-amine;

5-Cyclopropyl-4-(hexahydro-pyrrolo [3,4-b] [1,4] oxazin-4-yl)-2-(2-trifluoromethyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidine;

4-{4-[5-Cyclopropyl-4-(3,3-dimethyl-piperidin-4-ylamino)-pyrido[3,4-d]pyrimidin-2-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}-benzamide;

{5-Cyclopropyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((R)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

Azepan-4-yl-{5-cyclobutyl-2-[2-(3,5,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-amine;

Azepan-4-yl-{5-cyclobutyl-242-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-amine;

5 Cyclopropyl-4-(hexahydro-pyrrolo [3,4-b] [1,4] oxazin-6-yl)-2-(2-trifluoromethyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidine;

4-{4-[5-Cyclopropyl-4-(octahydro-pyrrolo [3,2-b]pyridin-1-yl)-pyrido[3,4-d]pyrimidin-2-yl]-1H-pyrrolo [2,3-b]pyridin-2-yl}-benzamide;

[4-(5-Cyclopropyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-pyridin-2-yl]-(1-methyl-1H-[1,2,4]triazol-3-yl)-amine;

[4-(5-Cyclopropyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-pyridin-2-yl]-(1-ethyl-1H-[1,2,4]triazol-3-yl)-amine;

5-Cyclopropyl-2-[2-(6-methyl-pyridin-3-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-4-piperazin-1-yl-pyrido[3,4-d]pyrimidine;

{5-Cyclopropyl-2-[2-(3-fluoro-pyridin-2-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(3-fluoro-pyridin-2-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((R)-3,3-dimethyl-piperidin-4-yl)-amine;

5-Cyclopropyl-2-[2-(3-fluoro-pyridin-2-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-4-(octahydro-pyrrolo [3,2-b]pyridin-1-yl)-pyrido[3,4-d]pyrimidine;

5-Cyclobutyl-2-[2-(3-fluoro-pyridin-2-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-4-(octahydro-pyrrolo [3,2-b]pyridin-1-yl)-pyrido[3,4-d]pyrimidine;

4-{4-[5-Cyclopropyl-4-(octahydro-pyrrolo [3,2-c]pyridin-1-yl)-pyrido[3,4-d]pyrimidin-2-yl]-1H-pyrrolo [2,3-b]pyridin-2-yl}-benzamide;

(±)-{5-Cyclobutyl-2-[2-(3,5,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((3,4-cis)-3-methoxy-piperidin-4-yl)-amine;

(±)-{5-Cyclobutyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((3,4-cis)-3-methoxy-piperidin-4-yl)-amine;

(±)-(3,4-trans)-4-({5-Cyclobutyl-2-[2-(3,5,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-methyl-amino)-3-methyl-piperidin-3-ol;

{5-Cyclobutyl-2-[2-(quinolin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-methyl-amine;

4-[5-Cyclopropyl-4-(3,3-dimethyl-piperidin-4-ylamino)-pyrido[3,4-d]pyrimidin-2-yl]-1H-pyrrolo [2,3-b]pyridine-2-carboxylic acid cyclohexylamide;

[4-(5-Cyclopropyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-pyridin-2-yl]-(1-phenyl-1H-[1,2,4]triazol-3-yl)-amine;

(1-Benzyl-1H-[1,2,4] triazol-3-yl)-[4-(5-cyclopropyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-pyridin-2-yl]-amine;

{5-Cyclobutyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((R)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(quinolin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((R)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(quinolin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

(±)-(3,4-trans)-4-{2-[2-(2-Chloro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-5-cyclopropyl-pyrido[3,4-d]pyrimidin-4-ylamino}-piperidin-3-ol;

2-Amino-4-[5-cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-ylamino]-cyclopentanecarboxylic acid amide;

2-Amino-4-{[5-cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-methyl-amino}-cyclopentanol;

[4-(5-Cyclopropyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-pyridin-2-yl]-(1,5-dimethyl-1H-[1,2,4] triazol-3-yl)-amine;

(±)-{5-Cyclobutyl-2-[2-(3,5,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((3,4-cis)-3-methyl-piperidin-4-yl)-amine;

(±)-{5-Cyclobutyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((3,4-cis)-3-methyl-piperidin-4-yl)-amine;

(±)-(3,4-trans)-4-{5-Cyclobutyl-2-[2-(3,5,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-ylamino}-piperidin-3-ol;

(±)-(3,4-trans)-4-{5-Cyclobutyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-ylamino}-piperidin-3-ol;

[5-Cyclobutyl-2-(2-methyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(3-fluoro-pyridin-2-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

(±)-[5-Cyclobutyl-2-(2-methyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-((3,4-cis)-3-methyl-piperidin-4-yl)-amine;

(±)-{5-Cyclobutyl-2-[2-(3,5,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((3,4-trans)-3-methyl-piperidin-4-yl)-amine;

(±)-{5-Cyclobutyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((3,4-trans)-3-methyl-piperidin-4-yl)-amine;

(±)-[5-Cyclobutyl-2-(2-methyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-((3,4-trans)-3-methyl-piperidin-4-yl)-amine;

5-Cyclopropyl-2-[2-(3-fluoro-pyridin-2-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-4-(hexahydro-pyrrolo [3,4-b][1,4]oxazin-4-yl)-pyrido[3,4-d]pyrimidine;

{2-[2-(2-Chloro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-5-cyclopropyl-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

(3-Aza-bicyclo [4.1.0]hept-6-yl)45-cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-amine;

[4-(5-Cyclopropyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-pyridin-2-yl]-(5-ethyl-1-methyl-1H-[1,2,4] triazol-3-yl)-amine;

[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{4-[5-Cyclopropyl-4-(hexahydro-pyrrolo [3,4-b] [1,4] oxazin-4-yl)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-yl}-(6-fluoro-pyridin-2-yl)-amine;

{4-[5-Cyclopropyl-4-(hexahydro-pyrrolo [3,4-b] [1,4] oxazin-4-yl)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-yl}-(3,5,6-trifluoro-pyridin-2-yl)-amine;

{4-[5-Cyclopropyl-4-(hexahydro-pyrrolo [3,4-b] [1,4] oxazin-4-yl)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-yl}-(3,6-difluoro-pyridin-2-yl)-amine;

2,4,6-Triisopropyl-benzenesulfonic acid 5-cyclobutyl-2-(9H-pyrido[2,3-b] indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl ester;

[4-(5-Cyclopropyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-pyridin-2-yl]-(5,6,7,8-tetrahydro-[1,2,4] triazolo [1,5-a]pyridin-2-yl)-amine;

4-[5-Cyclobutyl-4-(hexahydro-pyrrolo[3,4-b][1,4] oxazin-4-yl)-pyrido[3,4-d] pyrimidin-2-yl]-9H-pyrido[2,3-b] indole;

(±)-(1S,3S,4S)—N*1*-[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-4-fluoro-cyclopentane-1,3-diamine;

(3-Aza-bicyclo [4.1.0]hept-6-yl)-{5-cyclobutyl-2-[2-(3,5,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-amine;

(3-Aza-bicyclo [4.1.0]hept-6-yl)-{5-cyclobutyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-amine;

{5-Cyclobutyl-2-[2-(3-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(3,5-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

[5-Cyclopropyl-2-(2-methyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-((S)-3,3-dimethyl-piperidin-4-yl)-methyl-amine;

[2-(2-tert-Butyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-5-cyclobutyl-pyrido[3,4-d]pyrimidin-4-yl]-methyl-piperidin-4-yl-amine;

1-[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-pyrrolidin-3-ylamine;

4-(4-Piperazin-1-yl-5-trifluoromethyl-pyrido[3,4-d]pyrimidin-2-yl)-9H-pyrido[2,3-b]indole;

4-((3R,6R)-4-Hexahydro-pyrrolo [3,4-b]pyrrol-1-yl-5-trifluoromethyl-pyrido[3,4-d]pyrimidin-2-yl)-9H-pyrido[2,3-b]indole;

((S)-3,3-Dimethyl-piperidin-4-yl)-[2-(9H-pyrido[2,3-b]indol-4-yl)-5-trifluoromethyl-pyrido[3,4-d]pyrimidin-4-yl]-amine;

cis-N-[2-(9H-Pyrido [2,3-b]indol-4-yl)-5-trifluoromethyl-pyrido[3,4-d]pyrimidin-4-yl]-cyclobutane-1,3-diamine;

5-[2-(9H-Pyrido [2,3-b]indol-4-yl)-5-trifluoromethyl-pyrido[3,4-d]pyrimidin-4-ylamino]-azepan-3-ol;

2-Amino-4-{methyl-[2-(9H-pyrido[2,3-b]indol-4-yl)-5-trifluoromethyl-pyrido[3,4-d]pyrimidin-4-yl]-amino}-cyclopentanol;

1-[2-(9H-Pyrido [2,3-b]indol-4-yl)-5-trifluoromethyl-pyrido[3,4-d]pyrimidin-4-yl]-pyrrolidin-3-ylamine;

2-[2-(2-Chloro-5-fluoro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-5-cyclopropyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidine;

(±)-{5-Cyclopropyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((3,4-trans)-3-methyl-piperidin-4-yl)-amine;

(±)-{5-Cyclopropyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((3,4-cis)-3-methyl-piperidin-4-yl)-amine;

(±)-{5-Cyclopropyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}((2,4-cis)-2-methyl-piperidin-4-yl)-amine;

(±)-{5-Cyclopropyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}((2,4-trans)-2-methyl-piperidin-4-yl)-amine;

[5-Cyclopropyl-2-(2-trifluoromethyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

[5-Cyclobutyl-2-(2-trifluoromethyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido [3,4-d]pyrimidin-4-yl]-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{2-[2-(2-Chloro-5-fluoro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-5-cyclopropyl-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

Cis- or trans-(±)-5[5-Cyclobutyl-2-(9H-pyrido[2,3-b] indol-4-yl)-pyrido[3,4-d]pyrimidin-4-ylamino]-azepan-3-ol;

Trans- or cis-(±)-5-[5-Cyclobutyl-2-(9H-pyrido[2,3-b] indol-4-yl)-pyrido[3,4-d]pyrimidin-4-ylamino]-azepan-3-ol; or

[5-Cyclobutyl-2-(9H-pyrido[2,3-b] indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-(6-fluoro-azepan-4-yl)-amine;

rac-{5-Cyclopropyl-2-[2-(1-phenyl-1H-1,2,4-triazol-3-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

rac-{5-Cyclopropyl-2-[2-(1-phenyl-1H-1,2,4-triazol-3-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-methyl-amine;

{4-[5-Cyclopropyl-4-(octahydro-pyrrolo [3,2-c]pyridin-1-yl)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-yl}-(1-phenyl-1H-1,2,4-triazol-3-yl)-amine;

rac-(3aS,7aS)-1-{5-Cyclopropyl-2-[2-(1-phenyl-1H-1,2,4-triazol-3-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-octahydro-pyrrolo [3,2-c]pyridin-3a-ol;

rac-{2-[2-(1-Benzyl-1H-1,2,4-triazol-3-ylamino)-pyridin-4-yl]-5-cyclopropyl-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-amine;

rac-{2-[2-(1-Benzyl-1H-1,2,4-triazol-3-ylamino)-pyridin-4-yl]-5-cyclopropyl-pyrido[3,4-d]pyrimidin-4-yl}-(3,3-dimethyl-piperidin-4-yl)-methyl-amine;

(1-Benzyl-1H-1,2,4-triazol-3-yl)-{4-[5-cyclopropyl-4-(octahydro-pyrrolo [3,2-c]pyridin-1-yl)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-yl}-amine;

rac-(3aS,7aS)-1-{2-[2-(1-Benzyl-1H-1,2,4-triazol-3-ylamino)-pyridin-4-yl]-5-cyclopropyl-pyrido[3,4-d]pyrimidin-4-yl}-octahydro-pyrrolo [3,2-c]pyridin-3a-ol;

{5-Cyclopropyl-2-[2-([1,2,4]triazolo [1,5-a]pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{2-[2-(1-Benzyl-1H-1,2,4-triazol-3-ylamino)-pyridin-4-yl]-5-cyclopropyl-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(1-phenyl-1H-1,2,4-triazol-3-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl1-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{4-[5-Cyclopropyl-4-(octahydro-pyrrolo [3,2-b]pyridin-1-yl)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-yl}-[1,2,4]triazolo [1,5-a]pyridin-2-yl-amine;

{4-[5-Cyclopropyl-4-(octahydro-pyrrolo [3,2-b]pyridin-1-yl)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-yl}-(1-phenyl-1H-1,2,4-triazol-3-yl)-amine;

rac-(3R,4R)-4-[5-Cyclobutyl-2-(9H-pyrido[2,3-b] indol-4-yl)-pyrido[3,4-d]pyrimidin-4-ylamino]-3-methyl-piperidin-3-ol;

rac-(3R,4R)-4-[5-Cyclopropyl-2-(9H-pyrido[2,3-b] indol-4-yl)-pyrido[3,4-d]pyrimidin-4-ylamino]-3-methyl-piperidin-3-ol;

C—{(S)-1-[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-pyrrolidin-3-yl}-methylamine;

C—{(R)-1-[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-pyrrolidin-3-yl}-methylamine;

4-[5-Cyclobutyl-4-(2,7-diaza-spiro [4.5]dec-2-yl)-pyrido[3,4-d]pyrimidin-2-yl]-9H-pyrido[2,3-b] indole;

[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-morpholin-3-ylmethyl-amine;

(R)-1-[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-pyrrolidin-3-ol;

(S)-1-[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-pyrrolidin-3-ol;

{5-Cyclopropyl-2-[2-(2,6-difluoro-phenylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(2,6-difluoro-phenylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{4-[5-Cyclobutyl-4-(hexahydro-pyrrolo [3,4-b]-1,4-oxazin-4-yl)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-yl}-(3,6-difluoro-pyridin-2-yl)-amine;

5-Cyclobutyl-4-(hexahydro-pyrrolo [3,4-b]-1,4-oxazin-4-yl)-2-(2-methyl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidine;

{4-[5-Cyclobutyl-4-(hexahydro-pyrrolo [3,4-b]-1,4-oxazin-4-yl)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-yl}-(2,6-difluoro-phenyl)-amine;

5-Cyclobutyl-2-[2-(3-fluoro-pyridin-2-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-4-(hexahydro-pyrrolo [3,4-b]-1,4-oxazin-4-yl)-pyrido[3,4-d]pyrimidine;

{5-Cyclopropyl-2-[2-(3-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((2S,6R)-2,6-dimethyl-piperidin-4-yl)-amine;

rac-2-[2-[(3,6-difluoro-2-pyridyl)amino]-4-pyridyl]-N-(3,3-dimethyl-4-piperidyl)-5-methoxy-pyrido[3,4-d]pyrimidin-4-amine;

rac-5-cyclobutyl-N-[(3S,4S)-3-methyl-4-piperidyl]-2[2-(trifluoromethyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]pyrido[3,4-d]pyrimidin-4-amine;

rac-5-cyclobutyl-N-[(3R,4S)-3-methyl-4-piperidyl]-2[2-(trifluoromethyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]pyrido[3,4-d]pyrimidin-4-amine;

5-cyclobutyl-N-[(4S)-3,3-dimethyl-4-piperidyl]-2-[2-(3-pyridylamino)-4-pyridyl]pyrido[3,4-d]pyrimidin-4-amine;

5-cyclopropyl-N-[(4S)-3,3-dimethyl-4-piperidyl]-2-[2-[(5-fluoro-3-pyridyl)amino]-4-pyridyl]pyrido[3,4-d]pyrimidin-4-amine;

2-[2-[(5-chloro-3-pyridyl)amino]-4-pyridyl]-5-cyclopropyl-N-[(4S)-3,3-dimethyl-4-piperidyl]pyrido[3,4-d]pyrimidin-4-amine;

(2S)-2-[[4-[5-cyclopropyl-4-[[(4S)-3,3-dimethyl-4-piperidyl] amino]pyrido[3,4-d]pyrimidin-2-yl]-2-pyridyl] amino]-2-phenyl-acetic acid;

2-[2-[(3,6-difluoro-2-pyridyl)amino]-4-pyridyl]-N-[(4S)-3,3-dimethyl-4-piperidyl]-5-methoxy-pyrido[3,4-d]pyrimidin-4-amine;

N-[(4S)-3,3-dimethyl-4-piperidyl]-2-[2-[(3-fluoro-2-pyridyl)amino]-4-pyridyl]-5-methoxy-pyrido[3,4-d]pyrimidin-4-amine;

rac-(3S,4R)-4-{5-Cyclobutyl-2-[2-(quinolin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-ylaminol-piperidin-3-ol;

{5-Cyclobutyl-2-[2-(6-methyl-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

6-{4-[5-Cyclobutyl-4-((S)-3,3-dimethyl-piperidin-4-ylamino)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-ylamino}-2-methyl-nicotinonitrile;

rac-(3R,4R)-4-{5-Cyclobutyl-2-[2-(quinolin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-ylamino}-piperidin-3-ol;

{2-[2-(Benzoxazol-2-ylamino)-pyridin-4-yl]-5-cyclobutyl-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-([1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl1-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-([1,2,4] triazolo [1,5-a]pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(rac-(3R,4S)-3-methyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-([1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(rac-(3R,4R)-3-methyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(3,5,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido [3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((3R,4R)-3-methyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((3S,4S)-3-methyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(1-methyl-1H-benzimidazol-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(3-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(rac-(3R,4S)-3-methyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(3,5-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(rac-(3R,4S)-3-methyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(1-methyl-1H-indazol-3-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl1-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

rac-(3S,4S)-4-{5-Cyclobutyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-ylamino}-pyrrolidin-3-ol;

rac-(3R,4R)-4-{5-Cyclobutyl-2-[2-(3-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-ylamino}-piperidin-3-ol;

rac-(3R,4R)-4-{5-Cyclobutyl-2-[2-(3,5-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-ylamino}-piperidin-3-ol;

{5-Cyclobutyl-2-[2-(3-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(rac-(3R,4R)-3-methyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(3,5-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(rac-(3R,4R)-3-methyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(3,4,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(rac-(3R,4R)-3-methyl-piperidin-4-yl)-amine;

rac-(3S,4R)-4-{5-Cyclobutyl-2-[2-(3-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-ylamino 1-piperidin-3-ol;

rac-(3S,4R)-4-{5-Cyclobutyl-2-[2-(3,5-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-ylamino}-piperidin-3-ol;

rac-(3S,4R)-4-{5-Cyclobutyl-2-[2-(3,4,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-ylamino}-piperidin-3-ol;

{5-Cyclobutyl-2-[2-(3,4,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(rac-(3R,4S)-3-methyl-piperidin-4-yl)-amine;

rac-(3R,4R)-4-{5-Cyclobutyl-2-[2-(3,4,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-ylamino}-piperidin-3-ol;

{5-Cyclobutyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((3R,4S)-3-methyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((3S,4R)-3-methyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(3-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(rac-(3R,4S)-3-methyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(3,5-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(rac-(3R,4S)-3-methyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(3,4,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido [3,4-d]pyrimidin-4-yl}-(rac-(3R,4S)-3-methyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(3-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(rac-(3R,4R)-3-methyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(3,5-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(rac-(3R,4R)-3-methyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(3,4,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido [3,4-d]pyrimidin-4-yl}-(rac-(3R,4R)-3-methyl-piperidin-4-yl)-amine;

rac-(3S,4R)-4-{5-Cyclopropyl-2-[2-(3-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-ylamino}-piperidin-3-ol;

rac-(3S,4R)-4-{5-Cyclopropyl-2-[2-(3,5-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-ylamino}-piperidin-3-ol;

rac-(3S,4R)-4-{5-Cyclopropyl-2-[2-(3,4,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-ylamino}-piperidin-3-ol;

rac-(3R,4R)-4-{5-Cyclopropyl-2-[2-(3-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-ylamino}-piperidin-3-ol;

rac-(3R,4R)-4-{5-Cyclopropyl-2-[2-(3,5-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-ylamino}-piperidin-3-ol;

rac-(3R,4R)-4-{5-Cyclopropyl-2-[2-(3,4,6-trifluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-ylamino}-piperidin-3-ol;

6-{4-[5-Cyclobutyl-4-(rac-(3R,4S)-3-methyl-piperidin-4-ylamino)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-ylamino}-2-methyl-nicotinonitrile;

6-{4-[5-Cyclobutyl-4-(rac-(3R,4R)-3-methyl-piperidin-4-ylamino)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-ylamino}-2-methyl-nicotinonitrile;

6-{4-[5-Cyclobutyl-4-(rac-(3S,4R)-3-hydroxy-piperidin-4-ylamino)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-ylamino}-2-methyl-nicotinonitrile;

6-{4-[5-Cyclobutyl-4-(rac-(3R,4R)-3-hydroxy-piperidin-4-ylamino)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-ylamino}-2-methyl-nicotinonitrile;

{5-Cyclobutyl-2-[3-(3,6-difluoro-pyridin-2-ylamino)-phenyl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{2-[2-(5-Chloro-3-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-5-cyclobutyl-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

6-{4-[5-Cyclobutyl-4-((S)-3,3-dimethyl-piperidin-4-ylamino)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-ylamino}-pyridine-2-carbonitrile;

{5-Cyclobutyl-2-[2-(8-fluoro-quinolin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{2-[2-(5-Chloro-3-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-5-cyclopropyl-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

6-{4-[5-Cyclobutyl-4-((S)-3,3-dimethyl-piperidin-4-ylamino)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-ylaminol-5-fluoro-nicotinonitrile;

{5-Cyclobutyl-2-[3-(pyridin-2-ylamino)-phenyl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

6-{4-[5-Cyclobutyl-4-((S)-3,3-dimethyl-piperidin-4-ylamino)-pyrido[3,4-d]pyrimidin-2-yl]-pyridin-2-ylamino}-5-methyl-nicotinonitrile;

5-cyclobutyl-N-[(4S)-3,3-dimethyl-4-piperidyl]-2-[3-(pyrazin-2-ylamino)phenyl]pyrido[3,4-d]pyrimidin-4-amine;

5-cyclopropyl-N-[(4S)-3,3-dimethyl-4-piperidyl]-2-[2-[(3,4,6-trifluoro-2-pyridyl)amino]-4-pyridyl]pyrido[3,4-d]pyrimidin-4-amine;

5-cyclobutyl-N-[(4S)-3,3-dimethyl-4-piperidyl]-2-[2-[(3,4,6-trifluoro-2-pyridyl)amino]-4-pyridyl]pyrido[3,4-d]pyrimidin-4-amine;

N-[4-[5-cyclopropyl-4-[[(4S)-3,3-dimethyl-4-piperidyl] amino]pyrido[3,4-d]pyrimidin-2-yl]-2-pyridyl]-1,3-benzoxazol-2-amine;

5-cyclopropyl-N-[(4S)-3,3-dimethyl-4-piperidyl]-2-[2-(pyrazolo [1,5-a]pyridin-2-ylamino)-4-pyridyl]pyrido[3,4-d]pyrimidin-4-amine;

5-cyclobutyl-N-[(4S)-3,3-dimethyl-4-piperidyl]-2-[2-[(1-phenyl-1,2,4-triazol-3-yl)amino]-4-pyridyl]pyrido[3,4-d]pyrimidin-4-amine 4-(5-cyclobutyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-N-(1-phenyl-1,2,4-triazol-3-yl)pyridin-2-amine;

5-cyclopropyl-2-[2-[(3,6-difluoro-2-pyridyl)amino]-4-pyridyl]-N-[(4S)-3,3-dimethyl-4-piperidyl]-N-methyl-pyrido[3,4-d]pyrimidin-4-amine;

N-[4-[5-cyclopropyl-4-[[(4S)-3,3-dimethyl-4-piperidyl]amino]pyrido[3,4-d]pyrimidin-2-yl]-2-pyridyl]-6-fluoro-1,3-benzoxazol-2-amine;

“6-[[4-[5-cyclopropyl-4-[[(4S)-3,3-dimethyl-4-piperidyl]amino]pyrido[3,4-d]pyrimidin-2-yl]-2-pyridyl]amino]-5-fluoro-pyridine-3-carbonitrile;

5-cyclopropyl-2-[2-[(3,6-difluoro-2-pyridyl)amino]-4-pyridyl]-N-[(3S,4S)-3-methyl-4-piperidyl]pyrido[3,4-d]pyrimidin-4-amine;

5-cyclopropyl-2-[2-[(3,6-difluoro-2-pyridyl)amino]-4-pyridyl]-N-[(3R,4R)-3-methyl-4-piperidyl]pyrido[3,4-d]pyrimidin-4-amine;

2-[2-[(3-chloro-2-pyridyl)amino]-4-pyridyl]-5-cyclobutyl-N-[(4S)-3,3-dimethyl-4-piperidyl]pyrido[3,4-d]pyrimidin-4-amine

5-cyclobutyl-2-[2-[(3,5-dichloro-2-pyridyl)amino]-4-pyridyl]-N-[(4S)-3,3-dimethyl-4-piperidyl]pyrido[3,4-d]pyrimidin-4-amine

N-[4-[5-cyclobutyl-4-[[(4S)-3,3-dimethyl-4-piperidyl]amino]pyrido[3,4-d]pyrimidin-2-yl]-2-pyridyl]-6-fluoro-1,3-benzoxazol-2-amine;

2-[2-[(3-chloro-2-pyridyl)amino]-4-pyridyl]-5-cyclopropyl-N-[(4S)-3,3-dimethyl-4-piperidyl]pyrido[3,4-d]pyrimidin-4-amine;

5-cyclopropyl-2-[2-[(3,5-dichloro-2-pyridyl)amino]-4-pyridyl]-N-[(4S)-3,3-dimethyl-4-piperidyl]pyrido[3,4-d]pyrimidin-4-amine;

5-cyclobutyl-2-[2-[(3-fluoro-2-pyridyl)amino]-4-pyridyl]-N-[(3R,4R)-3-methyl-4-piperidyl]pyrido[3,4-d]pyrimidin-4-amine;

5-cyclobutyl-2-[2-[(3-fluoro-2-pyridyl)amino]-4-pyridyl]-N-[(3S,4S)-3-methyl-4-piperidyl]pyrido[3,4-d]pyrimidin-4-amine;

rac-(3R,4R)-4-Amino-1-[5-cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-pyrrolidin-3-ol;

rac-(3S,4R)-4-[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-ylamino]-piperidin-3-ol;

rac-(3R,4R)-4-[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-ylamino]-piperidin-3-ol;

[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-((3R,4R)-3-methyl-piperidin-4-yl)-amine;

[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-((3 S,4R)-3-methyl-piperidin-4-yl)-amine;

Piperidin-4-yl-[2-(9H-pyrido[2,3-b]indol-4-yl)-5-trifluoromethyl-pyrido[3,4-d]pyrimidin-4-yl]-amine;

rac-(3S,4R)-4-[2-(9H-Pyrido [2,3-b]indol-4-yl)-5-trifluoromethyl-pyrido[3,4-d]pyrimidin-4-ylamino]-piperidin-3-ol;

rac-(3R,4R)-4-[2-(9H-Pyrido [2,3-b]indol-4-yl)-5-trifluoromethyl-pyrido[3,4-d]pyrimidin-4-ylamino]-piperidin-3-ol;

rac-(3S,4R)-3-Methyl-piperidin-4-yl)-[2-(9H-pyrido[2,3-b]indol-4-yl)-5-trifluoromethyl-pyrido[3,4-d]pyrimidin-4-yl]-amine;

(rac-(3R,4R)-3-Methyl-piperidin-4-yl)-[2-(9H-pyrido[2,3-b]indol-4-yl)-5-trifluoromethyl-pyrido[3,4-d]pyrimidin-4-yl]-amine;

{5-Cyclopropyl-2-[2-(2,5-dichloro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

rac-(3R,4R)-4-{2-[2-(2-Chloro-5-fluoro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-5-cyclopropyl-pyrido[3,4-d]pyrimidin-4-ylamino}-3-methyl-piperidin-3-ol;

4-[5-Cyclopropyl-4-((S)-3,3-dimethyl-piperidin-4-ylamino)-pyrido[3,4-d]pyrimidin-2-yl]-1H-pyrrolo [2,3-b]pyridine-2-carboxylic acid cyclohexylamide;

5-Cyclopropyl-4-(octahydro-pyrrolo [3,2-c]pyridin-1-yl)-2-(2-pyridin-3-yl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidine;

{5-Cyclopropyl-2-[2-(2-methoxymethyl-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

rac-(1R,3 aS)-1-{2-[2-(2-Chloro-5-fluoro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-5-cyclopropyl-pyrido[3,4-d]pyrimidin-4-yl}-octahydro-pyrrolo [3,2-c]pyridin-3a-ol;

rac-(3R,4R)-4-({2-[2-(2-Chloro-5-fluoro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-5-cyclopropyl-pyrido[3,4-d]pyrimidin-4-yl}-methyl-amino)-3-methyl-piperidin-3-ol;

2-[2-(2-Chloro-5-fluoro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-5-cyclopropyl-4-(hexahydro-pyrrolo [3,4-b] [1,4] oxazin-4-yl)-pyrido[3,4-d]pyrimidine;

{5-Cyclopropyl-2-[2-(2,5-difluoro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(5-methyl-pyridin-3-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl1-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

Azepan-1-yl-{4-[5-cyclopropyl-4-((S)-3,3-dimethyl-piperidin-4-ylamino)-pyrido[3,4-d]pyrimidin-2-yl]-1H-pyrrolo [2,3-b]pyridin-2-yl}-methanone;

{5-Cyclopropyl-2-[2-(2-fluoro-5-methyl-pyridin-3-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(5-fluoro-pyridin-3-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

Azetidin-1-yl-[4-[5-cyclopropyl-44[(4S)-3,3-dimethyl-4-piperidyl] amino]pyrido[3,4-d]pyrimidin-2-yl]-1H-pyrrolo [2,3-b]pyridin-2-yl]methanone;

[5-Cyclobutyl-2-(2-pyridin-3-yl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{2-[2-(2-Chloro-5-methoxy-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-5-cyclopropyl-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

(S)-Azepan-4-yl[5-cyclopropyl-2-(2-pyridin-3-yl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-amine;

{5-Cyclobutyl-2-[2-(5-fluoro-pyridin-3-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

5-cyclopropyl-N-[(4S)-3,3-dimethyl-4-piperidyl]-2-[2-(4-pyridyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]pyrido[3,4-d]pyrimidin-4-amine;

N-[(4S)-3,3-dimethyl-4-piperidyl]-2-[2-(3-pyridyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-5-(trifluoromethyl)pyrido[3,4-d]pyrimidin-4-amine;

4-(5-Cyclopropyl-4-piperazin-1-yl-pyrido[3,4-d]pyrimidin-2-yl)-benzofuro [2,3-b]pyridine;

2-(benzofuro [2,3-b]pyridin-4-yl)-5-cyclopropyl-N-(4-piperidyl)pyrido[3,4-d]pyrimidin-4-amine;

5-{[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-methyl-amino}-hexahydro-cyclopentoxazol-2-one;

5-[5-Cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)-pyrido[3,4-d]pyrimidin-4-ylamino]-hexahydro-cyclopentoxazol-2-one;

2-amino-4-[[5-cyclobutyl-2-(9H-pyrido[2,3-b]indol-4-yl)pyrido[3,4-d]pyrimidin-4-yl] amino] cyclopentanecarboxamide;

{5-Cyclopropyl-2-[2-(quinolin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(pyrazolo [1,5-a]pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((R)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(pyrazolo [1,5-a]pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

rac-(3S,4R)-4-{5-Cyclobutyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-ylamino}-piperidin-3-ol;

{5-Cyclobutyl-2-[2-(4-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(6-methoxy-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(3-fluoro-pyridin-2-yl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-methyl-amine;

[5-Cyclopropyl-2-(2-pyridin-3-yl-1H-pyrrolo [2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-((S)-3,3-dimethyl-piperidin-4-yl)-methyl-amine;

{5-Cyclobutyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(rac-(2S,4S)-2-methyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(3,6-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-(rac-(2R,4S)-2-methyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclobutyl-2-[2-(5-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(3-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(3,5-difluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(4-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(5-fluoro-pyridin-2-ylamino)-pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(2-fluoro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl1-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

[5-Cyclopropyl-2-(2-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-4-yl)-pyrido[3,4-d]pyrimidin-4-yl]-((S)-3,3-dimethyl-piperidin-4-yl)-amine;

{5-Cyclopropyl-2-[2-(2-fluoro-phenyl)-1H-pyrrolo [2,3-b]pyridin-4-yl]-pyrido[3,4-d]pyrimidin-4-yl}-((S)-3,3-dimethyl-piperidin-4-yl)-methyl-amine;

or a salt thereof.

29. A composition comprising a compound according to claim 1 and/or a salt thereof and at least one pharmaceutically acceptable excipient.