IP Library › Granted Patent US 10,053,695
Granted Patent B2
US 10,053,695 · App. 14/669,663 · Granted Aug 21, 2018

Modulation of CCR10 signals for treatment of skin and intestinal inflammatory diseases and infection

Inventors: Na Xiong (State College, PA); Mingcan Xia (Brookline, MA)
Assignee: THE PENN STATE RESEARCH FOUNDATION
C12N15/1138A61K38/195A61K45/06C07K14/523C07K14/7158C12N15/113C12N2310/14
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Quick Facts
Patent No.
US 10,053,695
App. No.
14/669,663
Granted
Aug 21, 2018
Kind
B2
Abstract

The invention provides compositions and methods for targeting CCR10 and/or the CCR10/ligand axis to modulate the immune response in a subject.

Claims (1)

1. A method of inhibiting an immune response in a mammal suffering from psoriasis, the method comprising administering to the mammal in need thereof an effect amount of a composition comprising an activator of CCR10, wherein the activator is CCL27.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 23, 2018
From: XIONG, NA; XIA, MINGCAN
To: THE PENN STATE RESEARCH FOUNDATION
Reel/Frame 045013/0714 →
CONFIRMATORY LICENSE Recorded Jun 21, 2017
From: PENNSYLVANIA STATE UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 042922/0260 →
Continuity (2)
Provisional Application 61970451 · Mar 26, 2014
Related Publication 20150273054A1 · Oct 1, 2015