Small molecule inhibitors of MCL-1 and uses thereof

1. A compound having Formula I:

including pharmaceutically acceptable salts, solvates, and/or prodrugs thereof;

wherein R1 is selected from the group consisting of from

wherein R2 is selected from the group consisting of

and

wherein R3 is selected from the group consisting of hydrogen, OH, OCH 3 OCH 2 CH 3 COOH, COOCH 3 COOCH 2 CH 3 ,

wherein X, Y, Z are independently N, C or CO.

2. The compound of claim 1 , wherein the compound is able to bind the BH3 binding pocket of an Mcl-1 protein.

3. The compound of claim 1 , wherein said compound is selected from the group consisting of

pharmaceutically acceptable carrier.

4. A pharmaceutical composition comprising a compound of claim 1 .