Patent
Disclosed are sporicidal compositions, and methods of use thereof. The sporicidal compositions contain water, an organic solvent, and a spore-germinating agent containing an iodide source, a citrate source or both. The compositions have sporicidal activity against, e.g., Clostridium difficile spores. The sporicidal compositions can be used alone, or can form part of a disinfecting composition or an antiseptic composition.
1. A sporicidal composition, comprising:
water;
an amount q s of organic solvent, wherein q s is about 5% to about 60% w/w; and
an amount q g1 of spore-germinating agent, wherein q gi is about 0.05% to about 5% w/w;
wherein:
the organic solvent comprises a glycol, glycerine, a glycol ether, a polyethylene glycol or dimethyl isosorbide; and
the spore-germinating agent comprises:
an amount q i1 of iodide source, or
an amount q c1 of citrate source, or
a combination thereof;
wherein:
q g1 ≧q i1 +q c1 ; and
at least one of q i1 and q c1 is at least about 0.05% w/w.
2. The sporicidal composition of claim 1 ,
wherein:
the spore-germinating agent consists essentially of:
an amount q i1 of iodide source, or
an amount q c1 of citrate source, or
a combination thereof;
wherein:
q g1 ≧q i1 +q c1 ; and
at least one of q i1 and q c1 is at least about 0.05% w/w.
3. The sporicidal composition of claim 2 ,
wherein:
q g1 =q i1 +q c1 .
4. The sporicidal composition of claim 1 , wherein:
q g1 is about 0.10% to about 2.3% w/w; and
at least one of q i1 and q c1 is at least about 0.10% w/w.
5. A sporicidal composition, comprising:
water;
an amount q s organic solvent, wherein q s is about 5% to about 60% w/w; and
an amount q g2 spore-germinating agent, wherein q g2 is about 0.03% to about 3.8% w/w;
wherein:
the organic solvent comprises a glycol, glycerine, a glycol ether, a polyethylene glycol or dimethyl isosorbide; and
the spore-germinating agent comprises:
an amount q i2 of iodide, or
an amount q c2 of citrate, or
or a combination thereof;
wherein:
q g2 ≧q i2 +q c2 ; and
one or both of (a) and (b):
(a) q i2 is about 0.04% to about 3.8% w/w;
(b) q c2 is about 0.03% to about 3.2% w/w.
6. The sporicidal composition of claim 5 ,
wherein:
the spore-germinating agent consists essentially of:
an amount q i2 of iodide, or
an amount q c2 of citrate, or
or a combination thereof;
wherein:
q g2 ≧q i2 +q c2 ; and
one or both of (a) and (b):
(a) q i2 is about 0.04% to about 3.8% w/w;
(b) q c2 is about 0.03% to about 3.2% w/w.
7. The sporicidal composition of claim 6 ,
wherein:
q g2 =q i2 +q c2.
8. The sporicidal composition of claim 5 , wherein:
q g2 is about 0.06% to about 1.80% w/w; and
one or both of (a) and (b):
(a) q i2 is at least about 0.08% w/w;
(b) q c2 is at least about 0.06% w/w.
9. The sporicidal composition of claim 1 , wherein the organic solvent comprises glycerine, propylene glycol or butylene glycol.
10. The sporicidal composition of claim 1 , wherein the spore-germinating agent consists essentially of an iodide source or a combination of an iodide source and a citrate source.
11. The sporicidal composition of claim 1 , wherein the spore-germinating agent consists essentially of a citrate source or a combination of a citrate source and an iodide source.
12. The sporicidal composition of claim 10 , wherein the iodide source comprises potassium iodide.
13. The sporicidal composition of claim 11 , wherein the citrate source comprises citric acid, sodium citrate monobasic or a hydrate thereof, sodium citrate dibasic or a hydrate thereof, or sodium citrate tribasic or a hydrate thereof.
14. A disinfecting composition, comprising:
the sporicidal composition of claim 1 ; and
a disinfectant.
15. An antiseptic composition, comprising:
the sporicidal composition of claim 1 ; and
an antiseptic.
16. A method of reducing the bacterial spore count on a non-living tissue surface, comprising:
applying an effective amount of the composition of claim 1 to the surface;
wherein the spore bacteria comprise bacteria of the genus Clostridium.
17. A method of reducing the bacterial spore count on a living tissue surface, comprising:
applying an effective amount of the composition of claim 1 to the surface;
wherein the spore bacteria comprise bacteria of the genus Clostridium.