IP Library Granted Patent US 10,267,880
Granted Patent B2
US 10,267,880 · App. 14/697,040 · Granted Apr 23, 2019

Methods for producing a pulse-pair for magnetic resonance imaging and devices thereof

Inventors: Rebecca Emily Feldman (New York, NY); Haisam Mohammad Islam (Stanford, CA); Priti Balchandani (New York, NY)
Assignee: Icahn School of Medicine at Mount Sinai
G01R33/4835G01R33/288G01R33/4806G01R33/5659G01R33/56341G01R33/58
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Quick Facts
Patent No.
US 10,267,880
App. No.
14/697,040
Granted
Apr 23, 2019
Kind
B2
Abstract

A method, magnetic resonance imaging computing device, and a non-transitory computer readable medium for producing a pulse pair for magnetic resonance imaging. A pulse pair control signal comprising an adiabatic pulse and a matched phase non-adiabatic pulse is generated. The pulse pair control signal is transformed into a power independent of number of slices pulse pair. The Power Independent of Number of Slices pulse pair control signal is output to a waveform generator to produce the Power Independent of Number of Slices pulse pair in a spin echo sequence.

Claims (65)

1. A method for generating a magnetic resonance image, the method comprising:

generating, by a magnetic resonance imaging computing device, a pulse pair control signal comprising an adiabatic pulse and a matched phase non-adiabatic pulse;

transforming, by the magnetic resonance imaging computing device, the pulse pair control signal into a power independent of number of slices pulse pair control signal comprising a power independent of number of slices adiabatic pulse and a power independent of number of slices matched phase non-adiabatic pulse;

outputting, by the magnetic resonance imaging computing device, the power independent of number of slices pulse pair control signal to a waveform generator to produce the power independent of number of slices pulse pair in a spin echo sequence; and

generating, by the magnetic resonance imaging computing device, a magnetic resonance image based on the power independent of number of slices pulse pair.

2. The method as set forth in claim 1 , wherein the adiabatic pulse comprises a 180 degree adiabatic pulse and the matched phase non-adiabatic pulse comprises a 90 degree pulse.

3. The method as set forth in claim 1 , wherein the transforming further comprises:

sampling, by the magnetic resonance imaging computing device, the adiabatic pulse based on a first slice thickness to slice separation ratio; and

sampling, by the magnetic resonance imaging computing device, the matched phase pulse based on the first slice thickness to slice separation ratio.

4. The method as set forth in claim 3 , wherein the first slice thickness to slice separation ratio is about one-eighth.

5. The method as set forth in claim 3 , wherein the sampling comprises utilizing a comb function.

6. The method as set forth in claim 1 further comprising:

generating, by the magnetic resonance imaging computing device, a gradient pulse control signal for each of the sampled adiabatic pulse and the sampled matched phase pulse; and

outputting, by the magnetic resonance imaging computing device, the gradient pulse control signals to the waveform generator to produce the gradient pulses.

7. The method as set forth in claim 6 , wherein the gradient pulse control signals are configured to be capable of causing the waveform generator to interleave the gradient pulses with corresponding nulls in the power independent of number of slices pulse pair.

8. The method as set forth in claim 6 further comprising:

generating, by the magnetic resonance imaging computing device, the magnetic resonance image based on the power independent of number of slices pulse pair and the gradient pulses.

9. The method as set forth in claim 8 , wherein the magnetic resonance image comprises a structural image, a diffusion weighted image, or a functional image.

10. The method as set forth in claim 1 , wherein the adiabatic pulse comprises a bandwidth of about 1.11 kHz, a duration of 7 ms, and a peak radiofrequency amplitude of 17 μT.

11. The method as set forth in claim 1 , wherein a pulse duration of the adiabatic pulse is equal to the pulse duration of the matched phase pulse.

12. The method as set forth in claim 1 , wherein the pulse pair is semi-adiabatic.

13. A magnetic resonance imaging computing device comprising:

at least one processor;

and a memory coupled to the processor which is configured to be capable of executing programmed instructions comprising and stored in the memory to:

generate a pulse pair control signal comprising an adiabatic pulse and a matched phase non-adiabatic pulse;

transform the pulse pair control signal into a power independent of number of slices pulse pair comprising a power independent of number of slices adiabatic pulse and a power independent of number of slices matched phase non-adiabatic pulse;

output the power independent of number of slices pulse pair control signal to a waveform generator to produce the power independent of number of slices pulse pair in a spin echo sequence; and

generate a magnetic resonance image based on the power independent of number of slices pulse pair.

14. The device as set forth in claim 13 , wherein the adiabatic pulse comprises a 180 degree adiabatic pulse and the matched phase non-adiabatic pulse comprises a 90 degree pulse.

15. The method as set forth in claim 13 , wherein the processor coupled to the memory is further configured to be capable of executing at least one additional programmed instruction to:

sample the adiabatic pulse based on a first slice thickness to slice separation ratio; and

sample the matched phase pulse based on the first slice thickness to slice separation ratio.

16. The device as set forth in claim 15 , wherein the first slice thickness to slice separation ratio is about one-eighth.

17. The device as set forth in claim 15 , wherein the sampling comprises utilizing a comb function.

18. The device as set forth in claim 13 , wherein the processor coupled to the memory is further configured to be capable of executing at least one additional programmed instruction to:

generate a gradient pulse control signal for each of the sampled adiabatic pulse and the sampled matched phase pulse; and

output the generated gradient pulse control signals to the waveform generator to produce gradient pulses.

19. The device as set forth in claim 18 , wherein the gradient pulse control signals are configured to be capable of causing the waveform generator to interleave the gradient pulses with corresponding nulls in the power independent of number of slices pulse pair.

20. The device as set forth in claim 18 , wherein the processor coupled to the memory is further configured to be capable of executing at least one additional programmed instruction to:

generate the magnetic resonance image based on the power independent of number of slices pulse pair and the gradient pulses.

21. The device as set forth in claim 20 , wherein the magnetic resonance image comprises a structural image, a diffusion weighted image, or a functional image.

22. The device as set forth in claim 13 , wherein the adiabatic pulse comprises a bandwidth of about 1.11 kHz, a duration of 7 ms, and a peak radiofrequency amplitude of 17 μT.

23. The device as set forth in claim 13 , wherein a pulse duration of the adiabatic pulse is equal to the pulse duration of the matched phase pulse.

24. The device as set forth in claim 13 , wherein the pulse pair is semi-adiabatic.

25. A non-transitory computer readable medium having stored thereon instructions for generating a magnetic resonance image comprising executable code which when executed by a processor, causes the processor to perform steps comprising:

generating a pulse pair control signal comprising an adiabatic pulse and a matched phase non-adiabatic pulse;

transforming the pulse pair control signal into a power independent of number of slices pulse pair control signal comprising a power independent of number of slices adiabatic pulse and a power independent of number of slices matched phase non-adiabatic pulse;

outputting the power independent of number of slices pulse pair control signal to a waveform generator to produce the power independent of number of slices pulse pair in a spin echo sequence; and

generating a magnetic resonance image based on the power independent of number of slices pulse pair.

26. The medium as set forth in claim 25 , wherein the adiabatic pulse comprises a 180 degree adiabatic pulse and the matched phase non-adiabatic pulse comprises a 90 degree pulse.

27. The medium as set forth in claim 25 , wherein the transforming further comprises:

sampling the adiabatic pulse based on a first slice thickness to slice separation ratio; and

sampling the matched phase pulse based on the first slice thickness to slice separation ratio.

28. The medium as set forth in claim 27 , wherein the first slice thickness to slice separation ratio is about one-eighth.

29. The medium as set forth in claim 27 , wherein the sampling comprises utilizing a comb function.

30. The medium as set forth in claim 25 further comprising:

generating a gradient pulse control signal for each of the sampled adiabatic pulse and the sampled matched phase pulse; and

outputting the gradient pulse control signal to the waveform generator to produce gradient pulses.

31. The medium as set forth in claim 30 , wherein the gradient pulse control signals are configured to be capable of causing the waveform generator to interleave the gradient pulses with corresponding nulls in the power independent of number of slices pulse pair.

32. The medium as set forth in claim 31 further comprising:

generating the magnetic resonance image based on the power independent of number of slices pulse pair and the gradient pulses.

33. The medium as set forth in claim 32 , wherein the magnetic resonance image comprises a structural image, a diffusion weighted image, or a functional image.

34. The medium as set forth in claim 25 , wherein the adiabatic pulse comprises a bandwidth of about 1.11 kHz, a duration of 7 ms, and a peak radiofrequency amplitude of 17 μT.

35. The medium as set forth in claim 25 , wherein a pulse duration of the adiabatic pulse is equal to the pulse duration of the matched phase pulse.

36. The medium as set forth in claim 25 , wherein the pulse pair is semi-adiabatic.

Assignments (2)
CONFIRMATORY LICENSE Recorded Mar 16, 2017
From: STANFORD UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 042022/0058 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 2, 2015
From: FELDMAN, REBECCA EMILY; BALCHANDANI, PRITI
To: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Reel/Frame 037188/0432 →
Continuity (3)
Provisional Application 62112802 · Feb 6, 2015
Provisional Application 61984067 · Apr 25, 2014
Related Publication 20160116561A1 · Apr 28, 2016