Method for integrated sample acquisition and analyte measurement device
A region of skin, other than the fingertips, is stimulated. After stimulation, an opening is created in the skin (e.g., by lancing the skin) to cause a flow of body fluid from the region. At least a portion of this body fluid is transported to a testing device where the concentration of analyte (e.g., glucose) in the body fluid is then determined. It is found that the stimulation of the skin provides results that are generally closer to the results of measurements from the fingertips, the traditional site for obtaining body fluid for analyte testing.
1. A method of electrochemically determining a concentration of an analyte in blood, comprising:
manually rubbing a region of skin other than the fingertips for at least 1 second,
after manually rubbing, lancing the region of skin to provide no more than 1 microliter of blood sample at the region of skin;
contacting a sensor coupled to a meter to the blood sample to transport the blood sample to a sample chamber of the sensor; and
electrochemically determining the concentration of the analyte in the blood sample using the sensor and meter, wherein the analyte concentration is at least 10% nearer a concentration determined from blood obtained from a fingertip than a determination of the concentration of analyte from blood obtained from the region of skin without manually rubbing.
2. The method of claim 1 , wherein the analyte is glucose.
3. The method of claim 1 , wherein the transporting the blood sample to the sensor strip comprises transporting no more than 0.5 microliter of the blood sample to the sensor.
4. The method of claim 1 , wherein the transporting the blood sample to the sensor comprises transporting no more than 0.25 microliter of the blood sample to the sensor.
5. The method of claim 1 , wherein the step of manually rubbing a region of skin comprises stimulating a region of skin on a forearm.
6. The method of claim 1 , wherein the step of manually rubbing a region of skin comprises stimulating a region of skin on a calf.
7. The method of claim 1 , wherein the step of manually rubbing a region of skin comprises stimulating a region of skin on a thigh.
8. The method of claim 1 , wherein the step of manually rubbing a region of skin comprises stimulating a region of skin on a hand.
9. The method of claim 1 , wherein the step of manually rubbing a region of skin comprises stimulating a region of skin on a portion of an upper arm.
10. The method of claim 1 , wherein the step of manually rubbing a region of skin comprises stimulating a region of skin on an abdomen.
11. The method of claim 1 , wherein the sensor is a side-fill electrochemical sensor.
12. The method of claim 1 , wherein the sensor is a tip-fill elec 1 trochemical sensor.
13. The method of claim 1 , wherein the sensor comprises coplanar electrodes.
14. The method of claim 1 , wherein the sensor comprises facing electrodes.