Compositions and Methods for Antibodies Targeting Complement Protein C5
The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof.
1 - 16 . (canceled)
17 . An isolated antibody, or an antigen binding fragment thereof, comprising a heavy chain variable region having the sequence of SEQ ID NO: 7 and a light chain variable region having the sequence of SEQ ID NO: 8.
18 . The antibody, or an antigen binding fragment thereof, of claim 17 , wherein said antibody is a monoclonal antibody.
19 . The antibody, or an antigen binding fragment thereof, of claim 18 , wherein said antibody is a human or humanized antibody.
20 . The antibody, or an antigen binding fragment thereof, of claim 18 , wherein said antibody is a chimeric antibody.
21 . The antibody, or an antigen binding fragment thereof, of claim 18 , wherein said antibody comprises a human heavy chain constant region and a human light chain constant region.
22 . The antibody, or an antigen binding fragment thereof, of claim 18 , wherein said antibody is a single chain antibody.
23 . The antibody, or an antigen binding fragment thereof, of claim 18 , wherein said antibody is a Fab fragment.
24 . The antibody, or an antigen binding fragment thereof, of claim 18 , wherein said antibody is a scFv.
25 . The antibody, or an antigen binding fragment thereof, of claim 18 binds to both human complement C5 and cynomolgus complement C5.
26 . The antibody of claim 18 , or an antigen binding fragment thereof, is an IgG isotype.
27 . The antibody, or an antigen binding fragment thereof, of claim 17 , wherein said antibody comprises a heavy chain having the sequence of SEQ ID NO: 9 and a light chain having the sequence of SEQ ID NO: 10.