Granted Patent
B2
US 9,150,517 · App. 14/699,965 · Granted Oct 6, 2015
Bendamustine derivatives and methods of using same
Inventors:
Roger P. Bakale (Malvern, PA); Peter D. Brown (West Chester, PA); Jian Chen (West Chester, PA); Anthony S. Drager (Thorndale, PA); Rachel Y. Labell (Coatesville, PA); Robert E. McKean (Chester Springs, PA); Piyush R. Patel (Wallingford, PA); Renee C. Roemmele (Maple Glen, PA)
Assignee:
IGNYTA, INC.
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Abstract
The present invention is directed to bendamustine esters and bendamustine amides and their use for the treatment of cancer.
Claims (4)
1. A compound which is 4-{5-[bis-(chloroethyl)-amino]-1-methyl-1H-benzimidazol-2-yl}butyric acid dodecyl ester having the chemical structure
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising a compound which is 4-{5-[bis-(chloroethyl)-amino]-1-methyl-1H-benzimidazol-2-yl}butyric acid dodecyl ester having the chemical structure
or a pharmaceutically acceptable salt thereof, and one or more carriers or diluents.
Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 16, 2016
From: BAKALE, ROGER P.; CHEN, JIAN; DRAGER, ANTHONY S.; LABELL, RACHEL Y.; MCKEAN, ROBERT E.; PATEL, PIYUSH R.; ROEMMELE, RENEE C.
To: CEPHALON, INC.
Reel/Frame 039458/0678 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 16, 2016
From: BROWN, PETER D.; BAKALE, ROGER P.; CHEN, JIAN; DRAGER, ANTHONY S.; LABELL, RACHEL Y.; MCKEAN, ROBERT E.; PATEL, PIYUSH R.; ROEMMELE, RENEE C.
To: CEPHALON, INC.
Reel/Frame 039458/0687 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 16, 2016
From: CEPHALON, INC.
To: IGNYTA, INC.
Reel/Frame 039458/0705 →
Continuity (4)
Continuation
PCTUS2013069550
· Nov 12, 2013
Provisional Application
61725213
· Nov 12, 2012
Provisional Application
61776951
· Mar 12, 2013