USE OF LEVOCETIRIZINE AND MONTELUKAST IN THE TREATMENT OF INFLUENZA, COMMON COLD AND INFLAMMATION
The embodiments described herein include methods and formulations for treating influenza, common cold and associated acute inflammation. The methods and formulations include, but are not limited to, methods and formulations for delivering effective concentrations of levocetirizine and montelukast to a patient in need. The methods and formulations can comprise conventional and/or modified-release elements, providing for drug delivery to the patient.
1 . A method of treating chronic inflammation in a patient in need thereof comprising administering to the patient an effective amount of a combination of levocetirizine and montelukast.
2 . The method of claim 1 , wherein the chronic inflammation is non-IgE-mediated inflammation.
3 . The method of claim 1 , wherein the chronic inflammation is chronic rhinosinusitis.
4 . The method of claim 1 , wherein the chronic inflammation is a combination of non-IgE-mediated and IgE-mediated inflammation.
5 . The method of claim 1 , wherein the patient has nasal polyps.
6 . The method of claim 1 , wherein the combination is administered in a sequential manner.
7 . The method of claim 1 , wherein the combination is administered in a substantially simultaneous manner.
8 . The method of claim 1 , further comprising the administration of a steroid.
9 . The method of claim 1 , wherein the combination is administered to the patient by one or more of the routes consisting of enteral, intravenous, intraperitoneal, inhalation, intramuscular, subcutaneous and oral.
10 . The method of claim 9 , wherein the levocetirizine and montelukast are administered by the same route.
11 . A method of treating acute nasal and sinus inflammation in a patient in need thereof comprising administering to the patient an effective amount of a combination of levocetirizine and montelukast.
12 . The method of claim 11 , wherein the acute inflammation is caused by a viral infection.
13 . The method of claim 12 , wherein the viral infection is caused by a virus selected from the group consisting of: rhinovirus, coronavirus, influenza, human parainfluenza virus, human respiratory syncytial virus, adenovirus, enterovirus, and metapneumovirus or Epstein Barr virus.
14 . The method of claim 11 , wherein the combination is administered in a sequential manner.
15 . The method of claim 11 , wherein the combination is administered in a substantially simultaneous manner.
16 . A method of treating influenza in a patient in need thereof comprising administering to the patient an effective amount of a combination of levocetirizine and montelukast.
17 . The method of claim 16 , wherein the combination is administered at the onset of symptoms.
18 . The method of claim 16 , wherein the combination is administered in a sequential manner.
19 . The method of claim 16 , wherein the combination is administered in a substantially simultaneous manner.
20 . A method of treating cold symptoms in a patient in need thereof comprising administering to the patient an effective amount of a combination of levocetirizine and montelukast.
21 . The method of claim 20 , wherein the combination is administered at the onset of symptoms.
22 . The method of claim 20 , wherein the combination is administered in a sequential manner.
23 . The method of claim 20 , wherein the combination is administered in a substantially simultaneous manner.